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protein coding gene - bgs2 (SPAC24C9.07c) - spore wall 1,3-beta-glucan synthase catalytic subunit Bgs2

Gene summary

Standard name
bgs2
Systematic ID
SPAC24C9.07c
Product
spore wall 1,3-beta-glucan synthase catalytic subunit Bgs2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
meu21, pgs2
UniProt ID
O13967
ORFeome ID
39/39E08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3053214..3059282 reverse strand

Annotation

Complementation

PBO:0123295 - is not functionally complemented by S. cerevisiae FKS2

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GO biological process

GO:0034413 - ascospore wall (1->3)-beta-D-glucan biosynthetic process

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GO cellular component

GO:0000148 - 1,3-beta-D-glucan synthase complex

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GO:0005886 - plasma membrane

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GO:0005628 - prospore membrane

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GO molecular function

GO:0003843 - 1,3-beta-D-glucan synthase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0000175 - abnormal ascospore wall assembly

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000015 - RNA absent

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PomGeneEx:0000011 - RNA level increased

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PBO:0125053 - RNA present

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000175 - abnormal ascospore wall assembly

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Genotypes:

FYPO:0002467 - abnormal spore shape

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0004894 - decreased 1,3-beta-D-glucan synthase activity during sporulation

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Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

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Genotypes:

FYPO:0002150 - inviable spore population

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Genotypes:

FYPO:0004925 - irregular ascospore wall

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Genotypes:

FYPO:0004893 - normal 1,3-beta-D-glucan synthase activity during vegetative growth

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Genotypes:

FYPO:0003797 - normal conjugation frequency

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Genotypes:

FYPO:0002161 - normal growth on Calcofluor White

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Genotypes:

FYPO:0004892 - normal growth on echinocandin

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Genotypes:

FYPO:0001075 - normal growth on papulacandin B

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Genotypes:

FYPO:0000760 - normal mating

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Genotypes:

FYPO:0003563 - normal meiosis I

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Genotypes:

FYPO:0003798 - normal meiosis II

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Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

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Genotypes:

FYPO:0001310 - normal viability in stationary phase

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007358 - sensitive to heavy water

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002489 - spore lysis

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Genotypes:

FYPO:0003612 - viable spore population

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

Protein features

IDNameInterPro nameDB name
PF14288FKS1_dom1FKS1-like_dom1PFAM
PF23605FKS1_dom2FKS1-like_dom2PFAM
PF02364Glucan_synthaseGlyco_trans_48_domPFAM
SM01205FKS1_dom1_2FKS1-like_dom1SMART
PTHR12741LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMOBIDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:23907979 - The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway.
Cruz S et al. Microbiologyopen 2013 Oct;2(5):778-94
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:19189958 - Fission yeast rgf2p is a rho1p guanine nucleotide exchange factor required for spore wall maturation and for the maintenance of cell integrity in the absence of rgf1p.
García P et al. Genetics 2009 Apr;181(4):1321-34
PMID:11069657 - bgs2+, a sporulation-specific glucan synthase homologue is required for proper ascospore wall maturation in fission yeast.
Martín V et al. Mol Microbiol 2000 Oct;38(2):308-21
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:32142608 - Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water.
Kampmeyer C et al. ACS Synth Biol 2020 Apr 17;9(4):733-748
PMID:11895484 - Meu10 is required for spore wall maturation in Schizosaccharomyces pombe.
Tougan T et al. Genes Cells 2002 Feb;7(2):217-31
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16421249 - Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.
García P et al. Mol Biol Cell 2006 Apr;17(4):1620-31
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:10922478 - Bgs2p, a 1,3-beta-glucan synthase subunit, is essential for maturation of ascospore wall in Schizosaccharomyces pombe.
Liu J et al. FEBS Lett 2000 Jul 28;478(1-2):105-8