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protein coding gene - SPAC24C9.09 - mitochondrial threonine-tRNA ligase

Gene summary

Systematic ID
SPAC24C9.09
Product
mitochondrial threonine-tRNA ligase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13969
ORFeome ID
44/44E12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 3063687..3066413 forward strand

Annotation

Disease association

MONDO:0014398 - combined oxidative phosphorylation defect type 21

References:

GO biological process

GO:0032543 - mitochondrial translation

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0004829 - threonine-tRNA ligase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00587tRNA-synt_2baa-tRNA-synt_IIbPFAM
PF03129HGTP_anticodonAnticodon-bdPFAM
cd00771ThrRS_coreThrRS_coreCDD
PS50862AA_TRNA_LIGASE_IIaa-tRNA-synth_IIPROSITE_PROFILES
PR01047TRNASYNTHTHRThr-tRNA-ligase_IIaPRINTS
G3DSA:3.30.930.10:FF:000039FUNFAM
G3DSA:3.40.50.800:FF:000023FUNFAM
SSF52954Class II aaRS ABD-relatedSUPERFAMILY
SSF55681Class II aaRS and biotin synthetasesaa-tRNA-synth_II/BPL/LPLSUPERFAMILY
G3DSA:3.40.50.800Anticodon-bd_dom_sfGENE3D
G3DSA:3.30.930.10Bira Bifunctional Protein; Domain 2aa-tRNA-synth_II/BPL/LPLGENE3D
PTHR11451THREONINE-TRNA LIGASEPANTHER
TIGR00418thrSThr-tRNA-ligase_IIaNCBIFAM

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000051 - S. pombe keyword mapping
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531