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protein coding gene - cox8 (SPAC24C9.16c) - cytochrome c oxidase subunit VIII

Gene summary

Standard name
cox8
Systematic ID
SPAC24C9.16c
Product
cytochrome c oxidase subunit VIII
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P4W1
ORFeome ID
05/05A03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3042749..3043307 reverse strand

Annotation

GO biological process

GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen

References:

GO:1902600 - proton transmembrane transport

References:

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0005739 - mitochondrion

References:

GO:0045277 - respiratory chain complex IV

References:

GO molecular function

GO:0004129 - cytochrome-c oxidase activity

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0006141 - abolished cell population growth on gluconate carbon source

References:

Genotypes:

FYPO:0007618 - delayed onset of protein export from nucleus

References:

Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0007612 - increased transcription from STREP promoter

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02935COX7CCOX7C/Cox8Pfam
cd00929Cyt_c_Oxidase_VIIcCOX7C/Cox8CDD
G3DSA:4.10.49.10COX7C/Cox8_sfCATH-Gene3D
SSF81427COX7C/Cox8_sfSUPERFAMILY
PTHR13313COX7C/Cox8PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:30715423 - Queuine links translational control in eukaryotes to a micronutrient from bacteria.
Müller M et al. Nucleic Acids Res 2019 Apr 23;47(7):3711-3727
PMID:36797353 - Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor.
Moe A et al. Commun Chem 2023 Feb 16;6(1):32
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33400299 - Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.
Jiang G et al. Mol Microbiol 2021 Jun;115(6):1323-1338
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37939086 - Structure and function of the S. pombe III-IV-cyt c supercomplex.
Moe A et al. Proc Natl Acad Sci U S A 2023 Nov 14;120(46):e2307697120
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference