protein coding gene - cdc25 (SPAC24H6.05) - protein tyrosine phosphatase (M phase inducer) Cdc25

Gene summary

Standard name

cdc25

Systematic ID

SPAC24H6.05

Product

protein tyrosine phosphatase (M phase inducer) Cdc25

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

sal2

UniProt ID

P06652

ORFeome ID

40/40F12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 479228..482373 reverse strand

Annotation

Protein features

Orthologs

• CDC25A (HGNC:1725) Homo sapiens
• CDC25B (HGNC:1726) Homo sapiens
• CDC25C (HGNC:1727) Homo sapiens
• cdc25 (SJAG_04332) Schizosaccharomyces japonicus
• MIH1 (YMR036C) Saccharomyces cerevisiae

References / Literature

PMID:15629716 - Inactivation of the Cdc25 phosphatase by the stress-activated Srk1 kinase in fission yeast.

López-Avilés S et al. Mol Cell 2005 Jan 07;17(1):49-59

PMID:9034336 - Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.

Stern B et al. EMBO J 1997 Feb 03;16(3):534-44

PMID:12455694 - mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation.

Williams DR et al. Eukaryot Cell 2002 Oct;1(5):758-73

PMID:14701809 - Ddb1 is required for the proteolysis of the Schizosaccharomyces pombe replication inhibitor Spd1 during S phase and after DNA damage.

Bondar T et al. J Biol Chem 2004 Mar 12;279(11):9937-43

PMID:9383050 - Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.

Forsburg SL et al. Genetics 1997 Nov;147(3):1025-41

PMID:11029045 - A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.

Tournier S et al. Mol Biol Cell 2000 Oct;11(10):3411-24

PMID:1588914 - Five novel elements involved in the regulation of mitosis in fission yeast.

Warbrick E et al. Mol Gen Genet 1992 Apr;232(3):440-6

PMID:7774573 - Dominant mutants identify new roles for p34cdc2 in mitosis.

Labib K et al. EMBO J 1995 May 15;14(10):2155-65

PMID:7883794 - Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene.

Moreno S et al. J Cell Sci Suppl 1994;18:63-8

PMID:8389306 - Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

Kinoshita N et al. Genes Dev 1993 Jun;7(6):1059-71

PMID:9042863 - Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.

Rhind N et al. Genes Dev 1997 Feb 15;11(4):504-11

PMID:9108295 - The Schizosaccharomyces pombe cdc6 gene encodes the catalytic subunit of DNA polymerase delta.

Iino Y et al. Mol Gen Genet 1997 Mar 18;254(1):93-7

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:8521500 - p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

Correa-Bordes J et al. Cell 1995 Dec 15;83(6):1001-9

PMID:9348105 - DNA replication and order of cell cycle events: a role for protein isoprenylation?

Galli I et al. Biol Chem 1997 Sep;378(9):963-73

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:1756737 - p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast.

Millar JB et al. EMBO J 1991 Dec;10(13):4301-9

PMID:11018050 - Tea2p is a kinesin-like protein required to generate polarized growth in fission yeast.

Browning H et al. J Cell Biol 2000 Oct 02;151(1):15-28

PMID:32059768 - Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.

Sun XM et al. Curr Biol 2020 Apr 06;30(7):1217-1230.e7

PMID:9473044 - Coordination of initiation of nuclear division and initiation of cell division in Schizosaccharomyces pombe: genetic interactions of mutations.

Grallert A et al. J Bacteriol 1998 Feb;180(4):892-900

GO_REF:0000051 - S. pombe keyword mapping

PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.

Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57

PMID:1756736 - The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

Warbrick E et al. EMBO J 1991 Dec;10(13):4291-9

PMID:3796591 - Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe.

Booher R et al. Mol Cell Biol 1986 Oct;6(10):3523-30

PMID:1464318 - Pyp3 PTPase acts as a mitotic inducer in fission yeast.

Millar JB et al. EMBO J 1992 Dec;11(13):4933-41

PMID:1934126 - Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.

Grallert B et al. Curr Genet 1991 Aug;20(3):199-204

PMID:32612670 - Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe .

Alao JP et al. Cell Div 2020;15:10

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:15297457 - On the slowing of S phase in response to DNA damage in fission yeast.

Kumar S et al. J Biol Chem 2004 Oct 15;279(42):43574-80

PMID:7657164 - Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

Millar JB et al. Genes Dev 1995 Sep 01;9(17):2117-30

PMID:9303312 - Control of S-phase periodic transcription in the fission yeast mitotic cycle.

Baum B et al. EMBO J 1997 Aug 01;16(15):4676-88

PMID:24963130 - The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body.

Wälde S et al. J Cell Sci 2014 Aug 15;127(Pt 16):3625-40

PMID:21779494 - Ras signaling in yeast.

Tamanoi F Genes Cancer 2011 Mar;2(3):210-5

PMID:9200612 - tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell.

Mata J et al. Cell 1997 Jun 13;89(6):939-49

PMID:8497322 - Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

Walworth N et al. Nature 1993 May 27;363(6427):368-71

PMID:8557037 - Identification of a cdk-activating kinase in fission yeast.

Buck V et al. EMBO J 1995 Dec 15;14(24):6173-83

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:7796804 - A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.

Hayles J et al. EMBO J 1995 Jun 15;14(12):2760-71

PMID:7217015 - Isolation of cell size mutants of a fission yeast by a new selective method: characterization of mutants and implications for division control mechanisms.

Fantes PA J Bacteriol 1981 May;146(2):746-54

PMID:28272970 - Wee1 and Cdc25: Tools, pathways, mechanisms, questions.

Moseley JB Cell Cycle 2017 Apr 03;16(7):599-600

PMID:11085271 - spo12 is a multicopy suppressor of mcs3 that is periodically expressed in fission yeast mitosis.

Samuel JM et al. Mol Gen Genet 2000 Oct;264(3):306-16

PMID:8163491 - ntf1+ encodes a 6-cysteine zinc finger-containing transcription factor that regulates the nmt1 promoter in fission yeast.

Tang CS et al. J Biol Chem 1994 Apr 22;269(16):11921-6

PMID:16950131 - Phospho-regulation of the Cdc14/Clp1 phosphatase delays late mitotic events in S. pombe.

Wolfe BA et al. Dev Cell 2006 Sep;11(3):423-30

PMID:8621436 - A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition.

Gordon C et al. J Biol Chem 1996 Mar 08;271(10):5704-11

PMID:1427071 - Fission yeast genes involved in coupling mitosis to completion of DNA replication.

Enoch T et al. Genes Dev 1992 Nov;6(11):2035-46

PMID:9573052 - Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.

Bähler J et al. Genes Dev 1998 May 01;12(9):1356-70

PMID:7501024 - Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

Shiozaki K et al. Nature 1995 Dec 14;378(6558):739-43

PMID:7498766 - The role of cdc2 and other genes in meiosis in Schizosaccharomyces pombe.

Iino Y et al. Genetics 1995 Aug;140(4):1235-45

PMID:10523629 - DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding.

Zeng Y et al. Mol Cell Biol 1999 Nov;19(11):7410-9

PMID:8493104 - Study of multiple fibrillarin mRNAs reveals that 3' end formation in Schizosaccharomyces pombe is sensitive to cold shock.

Girard JP et al. Nucleic Acids Res 1993 Apr 25;21(8):1881-7

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:9843572 - The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast.

Kanoh J et al. Mol Biol Cell 1998 Dec;9(12):3321-34

PMID:18077559 - Biphasic incorporation of centromeric histone CENP-A in fission yeast.

Takayama Y et al. Mol Biol Cell 2008 Feb;19(2):682-90

PMID:35082773 - Phosphoinositide-Dependent Protein Kinases Regulate Cell Cycle Progression Through the SAD Kinase Cdr2 in Fission Yeast.

Liu K et al. Front Microbiol 2021;12:807148

PMID:28645196 - Antagonistic regulation of cyclin expression by the bZIP transcription factors Pcr1 and Atf1 during G2/M transition.

Bandyopadhyay S et al. FEMS Microbiol Lett 2017 Aug 01;364(14)

PMID:19713940 - Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring.

Takaine M et al. EMBO J 2009 Oct 21;28(20):3117-31

PMID:9001228 - A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2.

Matsumoto T Mol Cell Biol 1997 Feb;17(2):742-50

PMID:29813053 - Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

G Cortés JC et al. PLoS Genet 2018 May;14(5):e1007388

PMID:16428807 - Hip3 interacts with the HIRA proteins Hip1 and Slm9 and is required for transcriptional silencing and accurate chromosome segregation.

Greenall A et al. J Biol Chem 2006 Mar 31;281(13):8732-9

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:34085220 - Highly Synchronous Mitotic Progression in Schizosaccharomyces pombe Upon Relief of Transient Cdc2-asM17 Inhibition.

Singh P et al. Methods Mol Biol 2021;2329:123-142

PMID:9928931 - The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.

Grenon M et al. Mol Gen Genet 1999 Jan;260(6):522-34

PMID:22561704 - Regulation of cell cycle and stress responses under nitrosative stress in Schizosaccharomyces pombe.

Majumdar U et al. Free Radic Biol Med 2012 Jun 1;52(11-12):2186-200

PMID:16096637 - Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.

Kanai M et al. EMBO J 2005 Sep 07;24(17):3012-25

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:3448096 - Schizosaccharomyces pombe mutants affected in their division response to starvation.

Young PG et al. J Cell Sci 1987 Oct;88 ( Pt 3):295-304

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:7961734 - Low molecular weight protein-tyrosine phosphatases are highly conserved between fission yeast and man.

Mondesert O et al. J Biol Chem 1994 Nov 11;269(45):27996-9

PMID:18272791 - Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.

López-Avilés S et al. Mol Biol Cell 2008 Apr;19(4):1670-9

PMID:11460168 - A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast.

Gachet Y et al. Nature 2001 Jul 19;412(6844):352-5

PMID:19487461 - Cyclin-dependent kinase inhibits reinitiation of a normal S-phase program during G2 in fission yeast.

Kiang L et al. Mol Cell Biol 2009 Aug;29(15):4025-32

PMID:2474475 - cdc2 and the regulation of mitosis: six interacting mcs genes.

Molz L et al. Genetics 1989 Aug;122(4):773-82

PMID:8467814 - Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity.

Molz L et al. EMBO J 1993 Apr;12(4):1723-32

PMID:1464319 - Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast.

Millar JB et al. EMBO J 1992 Dec;11(13):4943-52

PMID:8413179 - Genetic analysis of human p34CDC2 function in fission yeast.

MacNeill SA et al. Mol Gen Genet 1993 Sep;240(3):315-22

PMID:8521469 - p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast.

Nishitani H et al. Cell 1995 Nov 03;83(3):397-405

PMID:16453724 - Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

Hirano T et al. EMBO J 1986 Nov;5(11):2973-9

PMID:20444100 - Hyperosmosis enhances radiation and hydroxyurea resistance of Schizosaccharomyces pombe checkpoint mutants through the spindle checkpoint and delayed cytokinesis.

Alao JP et al. Mol Microbiol 2010 Jul 01;77(1):143-57

PMID:22768388 - Translational control of cell division by Elongator.

Bauer F et al. Cell Rep 2012 May 31;1(5):424-33

PMID:1549179 - The wee1 protein kinase is required for radiation-induced mitotic delay.

Rowley R et al. Nature 1992 Mar 26;356(6367):353-5

PMID:2004705 - Genetic and molecular analysis of cdr1/nim1 in Schizosaccharomyces pombe.

Feilotter H et al. Genetics 1991 Feb;127(2):309-18

PMID:9182666 - Fission yeast dim1(+) encodes a functionally conserved polypeptide essential for mitosis.

Berry LD et al. J Cell Biol 1997 Jun 16;137(6):1337-54

PMID:2320127 - Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast.

Moreno S et al. Nature 1990 Apr 05;344(6266):549-52

PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.

Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81

PMID:31644361 - A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.

Opalko HE et al. Mol Biol Cell 2019 Dec 01;30(25):3015-3023

PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.

Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787

PMID:19487457 - The S. pombe mitotic regulator Cut12 promotes spindle pole body activation and integration into the nuclear envelope.

Tallada VA et al. J Cell Biol 2009 Jun 01;185(5):875-88

PMID:24006256 - Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase.

Yu ZY et al. J Cell Sci 2013 Nov 01;126(Pt 21):4995-5004

PMID:9843577 - The cdr2(+) gene encodes a regulator of G2/M progression and cytokinesis in Schizosaccharomyces pombe.

Breeding CS et al. Mol Biol Cell 1998 Dec;9(12):3399-415

PMID:3442828 - Isolation of a novel type of mutation in the mitotic control of Schizosaccharomyces pombe whose phenotypic expression is dependent on the genetic background and nutritional environment.

Ogden JE et al. Curr Genet 1986;10(7):509-14

PMID:11027263 - Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.

Snaith HA et al. Mol Cell Biol 2000 Nov;20(21):7922-32

PMID:1703321 - Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.

Gould KL et al. Science 1990 Dec 14;250(4987):1573-6

PMID:2178610 - Fission yeast cdc25 is a cell-cycle regulated protein.

Ducommun B et al. Biochem Biophys Res Commun 1990 Feb 28;167(1):301-9

PMID:9034337 - Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

O'Connell MJ et al. EMBO J 1997 Feb 03;16(3):545-54

PMID:1448087 - The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.

Ottilie S et al. Mol Cell Biol 1992 Dec;12(12):5571-80

PMID:8121488 - Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.

Moreno S et al. Nature 1994 Jan 20;367(6460):236-42

PMID:22174761 - Roles of the DYRK kinase Pom2 in cytokinesis, mitochondrial morphology, and sporulation in fission yeast.

Wu P et al. PLoS One 2011;6(12):e28000

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:9013342 - The size control of fission yeast revisited.

Sveiczer A et al. J Cell Sci 1996 Dec;109 ( Pt 12):2947-57

PMID:12399381 - The sal3(+) gene encodes an importin-beta implicated in the nuclear import of Cdc25 in Schizosaccharomyces pombe.

Chua G et al. Genetics 2002 Oct;162(2):689-703

PMID:11809834 - Fission yeast F-box protein Pof3 is required for genome integrity and telomere function.

Katayama S et al. Mol Biol Cell 2002 Jan;13(1):211-24

PMID:23349808 - Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.

Jourdain I et al. PLoS One 2013;8(1):e54142

PMID:27268234 - Both H4K20 mono-methylation and H3K56 acetylation mark transcription-dependent histone turnover in fission yeast.

Yang H et al. Biochem Biophys Res Commun 2016 Aug 05;476(4):515-521

PMID:30806623 - Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast.

Krüger LK et al. Elife 2019 Feb 26;8

PMID:7626804 - The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2.

Den Haese GJ et al. Mol Biol Cell 1995 Apr;6(4):371-85

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:9832516 - Suppressors of cdc25p overexpression identify two pathways that influence the G2/M checkpoint in fission yeast.

Forbes KC et al. Genetics 1998 Dec;150(4):1361-75

PMID:17804800 - Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast.

Murakami-Tonami Y et al. Proc Natl Acad Sci U S A 2007 Sep 11;104(37):14688-93

PMID:8799851 - The kinetics of the B cyclin p56cdc13 and the phosphatase p80cdc25 during the cell cycle of the fission yeast Schizosaccharomyces pombe.

Creanor J et al. J Cell Sci 1996 Jun;109 ( Pt 6):1647-53

PMID:9774107 - Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1.

Zeng Y et al. Nature 1998 Oct 01;395(6701):507-10

PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30

PMID:8824588 - The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

Wilkinson MG et al. Genes Dev 1996 Sep 15;10(18):2289-301

PMID:22912829 - Response to arsenate treatment in Schizosaccharomyces pombe and the role of its arsenate reductase activity.

Salgado A et al. PLoS One 2012;7(8):e43208

PMID:20974849 - Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.

Núñez A et al. J Biol Chem 2010 Dec 31;285(53):41366-73

PMID:2665944 - Regulation of p34cdc2 protein kinase during mitosis.

Moreno S et al. Cell 1989 Jul 28;58(2):361-72

PMID:29361524 - F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission yeast.

Qiu C et al. J Cell Sci 2018 Feb 02;131(3)

PMID:20231270 - Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.

Selvanathan SP et al. J Biol Chem 2010 May 07;285(19):14122-33

PMID:25422470 - Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.

Scheffler K et al. Proc Natl Acad Sci U S A 2014 Dec 16;111(50):17899-904

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:8635463 - Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25.

Nefsky B et al. EMBO J 1996 Mar 15;15(6):1301-12

PMID:26527280 - Robust Ordering of Anaphase Events by Adaptive Thresholds and Competing Degradation Pathways.

Kamenz J et al. Mol Cell 2015 Nov 05;60(3):446-59

PMID:11781565 - Feedback regulation of the MBF transcription factor by cyclin Cig2.

Ayté J et al. Nat Cell Biol 2001 Dec;3(12):1043-50

PMID:11812792 - Solution NMR study of the monomeric form of p13suc1 protein sheds light on the hinge region determining the affinity for a phosphorylated substrate.

Odaert B et al. J Biol Chem 2002 Apr 05;277(14):12375-81

PMID:9278510 - Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

Furnari B et al. Science 1997 Sep 05;277(5331):1495-7

PMID:3955656 - cdc25+ functions as an inducer in the mitotic control of fission yeast.

Russell P et al. Cell 1986 Apr 11;45(1):145-53

PMID:7808417 - A Drosophila gene encoding a DEAD box RNA helicase can suppress loss of wee1/mik1 function in Schizosaccharomyces pombe.

Warbrick E et al. Mol Gen Genet 1994 Dec 01;245(5):654-7

PMID:1819509 - stf1: a new suppressor of the mitotic control gene, cdc25, in Schizosaccharomyces pombe.

Hudson JD et al. Cold Spring Harb Symp Quant Biol 1991;56:599-604

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:11870212 - Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis.

West RR et al. J Cell Sci 2002 Mar 01;115(Pt 5):931-40

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:3453113 - The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis.

Russell P et al. Cell 1987 May 22;49(4):569-76

PMID:7957060 - Premature chromatin condensation upon accumulation of NIMA.

O'Connell MJ et al. EMBO J 1994 Oct 17;13(20):4926-37

PMID:9572736 - Replication checkpoint enforced by kinases Cds1 and Chk1.

Boddy MN et al. Science 1998 May 08;280(5365):909-12

PMID:17531813 - Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.

Hermand D et al. Mol Cell 2007 May 25;26(4):553-63

PMID:22182414 - Small heat-shock protein Hsp9 has dual functions in stress adaptation and stress-induced G2-M checkpoint regulation via Cdc25 inactivation in Schizosaccharomyces pombe.

Ahn J et al. Biochem Biophys Res Commun 2012 Jan 06;417(1):613-8

PMID:8860233 - Forces acting on the fission yeast anaphase spindle.

Hagan IM et al. Cell Motil Cytoskeleton 1996;34(1):69-75

PMID:8187760 - Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth.

Snell V et al. EMBO J 1994 May 01;13(9):2066-74

PMID:9614176 - Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast.

Stern B et al. Mol Biol Cell 1998 Jun;9(6):1309-21

PMID:9923681 - Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein.

Lopez-Girona A et al. Nature 1999 Jan 14;397(6715):172-5

PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.

Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:10101168 - The role of nucleotide binding and hydrolysis in the function of the fission yeast cdc18(+) gene product.

DeRyckere D et al. Genetics 1999 Apr;151(4):1445-57

PMID:9023111 - The fission yeast UVDR DNA repair pathway is inducible.

Davey S et al. Nucleic Acids Res 1997 Mar 01;25(5):1002-8

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