protein coding gene - atg14 (SPAC25A8.02) - autophagy associated protein Atg14

Gene summary

Standard name

atg14

Systematic ID

SPAC25A8.02

Product

autophagy associated protein Atg14

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O42862

ORFeome ID

18/18E11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 2102329..2104103 forward strand

Annotation

Protein features

Orthologs

• ATG14 (HGNC:19962) Homo sapiens
• atg14 (SJAG_02699) Schizosaccharomyces japonicus
• ATG14 (YBR128C) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:26365378 - ESCRTs Cooperate with a Selective Autophagy Receptor to Mediate Vacuolar Targeting of Soluble Cargos.

Liu XM et al. Mol Cell 2015 Sep 17;59(6):1035-42

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:34499173 - Visual detection of binary, ternary and quaternary protein interactions in fission yeast using a Pil1 co-tethering assay.

Yu ZQ et al. J Cell Sci 2021 Oct 01;134(19)

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:27737912 - Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast.

Zhao D et al. J Cell Sci 2016 Nov 15;129(22):4289-4304

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:30116786 - Genetic regulation of mitotic competence in G 0 quiescent cells.

Sajiki K et al. Sci Adv 2018 Aug;4(8):eaat5685

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:40395999 - Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast.

Ohtsuka H et al. Autophagy Rep 2022;1(1):51-64

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:22146723 - Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.

Ikebe C et al. Biosci Biotechnol Biochem 2011;75(12):2364-70

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26696398 - Autophagy is required for efficient meiosis progression and proper meiotic chromosome segregation in fission yeast.

Matsuhara H et al. Genes Cells 2016 Jan;21(1):65-87

PMID:41917004 - Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast.

Ma ZH et al. Nat Commun 2026 Mar 31;

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.

Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9

PMID:31941401 - Atg38-Atg8 interaction in fission yeast establishes a positive feedback loop to promote autophagy.

Yu ZQ et al. Autophagy 2020 Nov;16(11):2036-2051

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008