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protein coding gene - mss51 (SPAC25B8.04c) - mitochondrial cytochrome c oxidase assembly protein Mss51

Gene summary

Standard name
mss51
Systematic ID
SPAC25B8.04c
Product
mitochondrial cytochrome c oxidase assembly protein Mss51
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTB4
ORFeome ID
17/17H07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4160598..4162152 reverse strand

Annotation

GO biological process

GO:0033617 - mitochondrial respiratory chain complex IV assembly

References:

GO:0034551 - mitochondrial respiratory chain complex III assembly

References:

GO cellular component

GO:0099617 - matrix side of mitochondrial inner membrane

References:

GO:0005759 - mitochondrial matrix

References:

GO:0031966 - mitochondrial membrane

References:

Modification

MOD:00006 - N-glycosylated residue

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003730 - abolished cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0001938 - decreased cytochrome-c oxidase activity

References:

Genotypes:

FYPO:0003915 - decreased mitochondrial protein level

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0004960 - normal mitochondrial RNA level

References:

Genotypes:

FYPO:0004529 - normal mitochondrial translation

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF13824zf-Mss51Mss51_ZnfPFAM
PF20179MSS51_CMss51-like_CPFAM
PTHR28069GH20023PPANTHER

Orthologs

References / Literature

PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
GO_REF:0000051 - S. pombe keyword mapping
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:27257059 - Ribosome recycling defects modify the balance between the synthesis and assembly of specific subunits of the oxidative phosphorylation complexes in yeast mitochondria.
Ostojić J et al. Nucleic Acids Res 2016 Jul 08;44(12):5785-97
PMID:19858289 - Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis.
Fontanesi F et al. Mol Cell Biol 2010 Jan;30(1):245-59
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:22349564 - Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis.
Kühl I et al. Mitochondrion 2012 May;12(3):381-90
PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Liu NN et al. Cell Res 2010 Aug;20(8):963-5
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36