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protein coding gene - pop100 (SPAC25B8.16) - RNase P and RNase MRP subunit Pop100

Gene summary

Standard name
pop100
Systematic ID
SPAC25B8.16
Product
RNase P and RNase MRP subunit Pop100
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UTA4
ORFeome ID
27/27H04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4187314..4189859 forward strand

Annotation

Disease association

MONDO:0054561 - anauxetic dysplasia 2

References:

GO biological process

GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

References:

GO:0001682 - tRNA 5'-leader removal

References:

GO:0008033 - tRNA processing

References:

GO cellular component

GO:0005655 - nucleolar ribonuclease P complex

References:

GO:0005730 - nucleolus

References:

GO:0005634 - nucleus

References:

GO:0000172 - ribonuclease MRP complex

References:

GO:0030677 - ribonuclease P complex

References:

GO molecular function

GO:0000171 - ribonuclease MRP activity

References:

GO:0004526 - ribonuclease P activity

References:

GO:0000049 - tRNA binding

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF06978POP1_NPop1_NPfam
PF08170POPLDPOPLD_domPfam
PF22770POP1_CPOP1_CPfam
SSF103025SUPERFAMILY
PTHR22731Pop1PANTHER

Orthologs

References / Literature

PMID:8223594 - Identification of a 100-kDa protein associated with nuclear ribonuclease P activity in Schizosaccharomyces pombe.
Zimmerly S et al. Eur J Biochem 1993 Oct 15;217(2):501-7
PMID:35277511 - The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.
Porat J et al. Nat Commun 2022 Mar 11;13(1):1277
PMID:25401760 - RNase MRP cleaves pre-tRNASer-Met in the tRNA maturation pathway.
Saito Y et al. PLoS One 2014;9(11):e112488
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:6262315 - Partial purification of RNase P from Schizosaccharomyces pombe.
Kline L et al. J Biol Chem 1981 May 25;256(10):5058-63
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:10759889 - Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.
Ding DQ et al. Genes Cells 2000 Mar;5(3):169-90
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527