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protein coding gene - rec10 (SPAC25G10.04c) - meiotic recombination protein Rec10

Gene summary

Standard name
rec10
Systematic ID
SPAC25G10.04c
Product
meiotic recombination protein Rec10
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
rec20
UniProt ID
Q09823
ORFeome ID
33/33G11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4301367..4303893 reverse strand

Annotation

Comment

PBO:0001192 - promoter contains MCB

References:

GO biological process

GO:0042138 - meiotic DNA double-strand break formation

References:

GO:0007131 - reciprocal meiotic recombination

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GO cellular component

GO:0000785 - chromatin

References:

GO:0030998 - linear element

References:

GO:0005634 - nucleus

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GO molecular function

GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

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Genotypes:

Protein sequence feature

SO:0001528 - nuclear_localization_signal

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004585 - abnormal linear element morphology

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Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0000909 - abnormal protein localization to linear element

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Genotypes:

FYPO:0002957 - abnormal protein localization to nucleus during meiosis

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Genotypes:

FYPO:0005057 - abolished meiotic DNA double-strand break clipping

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Genotypes:

FYPO:0003181 - abolished meiotic DNA double-strand break formation

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Genotypes:

FYPO:0000484 - abolished meiotic recombination

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Genotypes:

FYPO:0006161 - abolished protein localization to chromatin during meiosis I

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Genotypes:

FYPO:0007146 - abolished protein localization to nucleus, with protein mislocalized to cytoplasm, during meiotic cell cycle

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Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0000485 - decreased meiotic recombination

References:

Genotypes:

FYPO:0004058 - decreased meiotic recombination at CRE promoter

References:

Genotypes:

FYPO:0006164 - decreased protein localization to linear element

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Genotypes:

FYPO:0006185 - decreased protein localization to nucleus during prophase I

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Genotypes:

FYPO:0003540 - decreased regional homologous chromosome pairing

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Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0004665 - linear elements absent from cell

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Genotypes:

FYPO:0004295 - multiseptate cell

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Genotypes:

FYPO:0007939 - normal chromatin loop formation during meiotic prophase I

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Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0005578 - normal intergenic meiotic recombination

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Genotypes:

FYPO:0003891 - normal intragenic meiotic recombination

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Genotypes:

FYPO:0003613 - normal meiotic sister chromatid cohesion during meiotic prophase I

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Genotypes:

FYPO:0004995 - normal onset of meiosis I

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Genotypes:

FYPO:0002043 - normal premeiotic DNA replication

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Genotypes:

FYPO:0004634 - normal protein level during meiosis

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Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0006162 - normal protein localization to chromatin during meiosis I

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Genotypes:

FYPO:0005135 - normal protein localization to linear element

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000678 - unequal homologous chromosome segregation

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07964Red1Red1/Rec10PFAM
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMOBIDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:19756689 - SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.
Spirek M et al. Chromosoma 2010 Feb;119(1):59-72
PMID:18514516 - Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination.
Davis L et al. Curr Biol 2008 Jun 03;18(11):849-54
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:35333350 - Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.
Sakuno T et al. Nucleic Acids Res 2022 Apr 22;50(7):3799-3816
PMID:1541389 - Seventeen complementation groups of mutations decreasing meiotic recombination in Schizosaccharomyces pombe.
De Veaux LC et al. Genetics 1992 Feb;130(2):251-62
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.
Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:19752195 - Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.
Milman N et al. Mol Cell Biol 2009 Nov;29(22):5998-6005
PMID:20421495 - RNAi and heterochromatin repress centromeric meiotic recombination.
Ellermeier C et al. Proc Natl Acad Sci U S A 2010 May 11;107(19):8701-5
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21429938 - Functional interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex.
Bonfils S et al. J Cell Sci 2011 Apr 15;124(Pt 8):1328-38
PMID:23395004 - Protein determinants of meiotic DNA break hot spots.
Fowler KR et al. Mol Cell 2013 Mar 07;49(5):983-96
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:28469148 - Functional organization of protein determinants of meiotic DNA break hotspots.
Ma L et al. Sci Rep 2017 May 03;7(1):1393
PMID:32790622 - Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers.
Bravo Núñez MA et al. Elife 2020 Aug 13;9
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16532353 - Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe.
Lorenz A et al. Chromosoma 2006 Aug;115(4):330-40
PMID:10882124 - Meiotic DNA breaks associated with recombination in S. pombe.
Cervantes MD et al. Mol Cell 2000 May;5(5):883-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21387406 - Rec10- and Rec12-independent recombination in meiosis of Schizosaccharomyces pombe.
Mallela S et al. Yeast 2011 May;28(5):405-21
PMID:20622014 - Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.
St-André O et al. J Biol Chem 2010 Sep 03;285(36):27859-68
PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.
Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876
PMID:8299939 - Region-specific activators of meiotic recombination in Schizosaccharomyces pombe.
DeVeaux LC et al. Genes Dev 1994 Jan;8(2):203-10
PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.
Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30
PMID:24210919 - Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.
Lee NN et al. Cell 2013 Nov 21;155(5):1061-74
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22841486 - A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint.
Miyoshi T et al. Mol Cell 2012 Sep 14;47(5):722-33
PMID:16043696 - Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe.
Ellermeier C et al. Proc Natl Acad Sci U S A 2005 Aug 02;102(31):10952-7
PMID:15226405 - S. pombe meiotic linear elements contain proteins related to synaptonemal complex components.
Lorenz A et al. J Cell Sci 2004 Jul 01;117(Pt 15):3343-51
PMID:22362333 - Mug20, a novel protein associated with linear elements in fission yeast meiosis.
Estreicher A et al. Curr Genet 2012 Apr;58(2):119-27
PMID:31665745 - Conserved HORMA domain-containing protein Hop1 stabilizes interaction between proteins of meiotic DNA break hotspots and chromosome axis.
Kariyazono R et al. Nucleic Acids Res 2019 Nov 04;47(19):10166-10180
PMID:30217891 - Physical basis for long-distance communication along meiotic chromosomes.
Fowler KR et al. Proc Natl Acad Sci U S A 2018 Oct 02;115(40):E9333-E9342
PMID:33825974 - Linear elements are stable structures along the chromosome axis in fission yeast meiosis.
Ding DQ et al. Chromosoma 2021 Sep;130(2-3):149-162
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:7586030 - Molecular cloning of the meiosis-induced rec10 gene of Schizosaccharomyces pombe.
Lin Y et al. Curr Genet 1995 Apr;27(5):440-6
PMID:9136000 - The Schizosaccharomyces pombe rec16 gene product regulates multiple meiotic events.
Li YF et al. Genetics 1997 May;146(1):57-67
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:2806887 - Meiotic recombination-deficient mutants of Schizosaccharomyces pombe.
Ponticelli AS et al. Genetics 1989 Sep;123(1):45-54
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:25993311 - Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.
Phadnis N et al. PLoS Genet 2015 May;11(5):e1005225
PMID:12665553 - Linear element formation and their role in meiotic sister chromatid cohesion and chromosome pairing.
Molnar M et al. J Cell Sci 2003 May 01;116(Pt 9):1719-31
PMID:33526714 - Activation of meiotic recombination by nuclear import of the DNA break hotspot-determining complex in fission yeast.
Wintrebert M et al. J Cell Sci 2021 Feb 22;134(4)
PMID:9671035 - Global control of meiotic recombination genes by Schizosaccharomyces pombe rec16 (rep1).
Ding R et al. Mol Gen Genet 1998 Jun;258(6):663-70