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protein coding gene - mde5 (SPAC25H1.09) - glycosyl hydrolase family 13, meiosis specific, Mde5

Gene summary

Standard name
mde5
Systematic ID
SPAC25H1.09
Product
glycosyl hydrolase family 13, meiosis specific, Mde5
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
meu30, SPAC4A8.01
UniProt ID
O14154
ORFeome ID
25/25A03
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome I: 2538442..2540081 forward strand

Annotation

GO cellular component

GO:0009897 - external side of plasma membrane

References:

Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00818 - glycosylphosphatidylinositolated residue

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MOD:00006 - N-glycosylated residue

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Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0000110 - orthologs cannot be distinguished

Protein features

IDNameInterPro nameDB name
PF00128Alpha-amylaseGH13_cat_domPFAM
PF09260A_amylase_dom_CA_amylase_C_domPFAM
cd11319AmyAc_euk_AmyACDD
SM00642aamyGH13_cat_domSMART
G3DSA:3.20.20.80:FF:000120FUNFAM
SSF51445(Trans)glycosidasesGH_hydrolase_sfSUPERFAMILY
SSF51011Glycosyl hydrolase domainSUPERFAMILY
G3DSA:3.20.20.80GlycosidasesGENE3D
G3DSA:2.60.40.1180Glyco_hydro_bGENE3D
PTHR10357ALPHA-AMYLASE FAMILY MEMBERPANTHER
PIRSF001024Alph-amyl_fungA-amylase-likePIRSF

Orthologs

References / Literature

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:10747048 - Autoregulated expression of Schizosaccharomyces pombe meiosis-specific transcription factor Mei4 and a genome-wide search for its target genes.
Abe H et al. Genetics 2000 Apr;154(4):1497-508
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:12845604 - Genome-wide identification of fungal GPI proteins.
De Groot PW et al. Yeast 2003 Jul 15;20(9):781-96
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.
Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:40668835 - α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.
Jacob A et al. Proc Natl Acad Sci U S A 2025 Jul 22;122(29):e2505509122