PomBase home

protein coding gene - atp19 (SPAC25H1.10c) - F1-FO ATP synthase F(o) subunit K, Atp19

Gene summary

Standard name
atp19
Systematic ID
SPAC25H1.10c
Product
F1-FO ATP synthase F(o) subunit K, Atp19
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
C6Y4A3
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 2532754..2533260 reverse strand

Annotation

Disease association

MONDO:0009723 - Leigh syndrome

References:

MONDO:0032869 - mitochondrial complex 5 (ATP synthase) deficiency, nuclear type 6

References:

GO biological process

GO:0042776 - proton motive force-driven mitochondrial ATP synthesis

References:

GO cellular component

GO:0099617 - matrix side of mitochondrial inner membrane

References:

GO:0045259 - proton-transporting ATP synthase complex

References:

GO molecular function

GO:0046933 - proton-transporting ATP synthase activity, rotational mechanism

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009078 - decreased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

References:

Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
PF11022ATP19ATP19PFAM
PTHR28074ATP SYNTHASE SUBUNIT K, MITOCHONDRIALATP19PANTHER

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:29917077 - USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis.
Barca E et al. Hum Mol Genet 2018 Oct 01;27(19):3305-3312
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:18488015 - Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution.
Wilhelm BT et al. Nature 2008 Jun 26;453(7199):1239-43
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:29440398 - Assembly of the membrane domain of ATP synthase in human mitochondria.
He J et al. Proc Natl Acad Sci U S A 2018 Mar 20;115(12):2988-2993
PB_REF:0000003 - Disease Association Curation