protein coding gene - pyp1 (SPAC26F1.10c) - protein tyrosine phosphatase Pyp1

Gene summary

Standard name

pyp1

Systematic ID

SPAC26F1.10c

Product

protein tyrosine phosphatase Pyp1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P27574

ORFeome ID

34/34F11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 5161512..5163360 forward strand

Annotation

Protein features

Orthologs

• PTPN1 (HGNC:9642) Homo sapiens
• PTPN2 (HGNC:9650) Homo sapiens
• pyp1 (SJAG_02013) Schizosaccharomyces japonicus
• PTP3 (YER075C) Saccharomyces cerevisiae
• PTP2 (YOR208W) Saccharomyces cerevisiae

References / Literature

PMID:7501024 - Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

Shiozaki K et al. Nature 1995 Dec 14;378(6558):739-43

PMID:10398679 - Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases.

Nguyen AN et al. Genes Dev 1999 Jul 01;13(13):1653-63

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:7937842 - Negative regulation of mitosis in fission yeast by catalytically inactive pyp1 and pyp2 mutants.

Hannig G et al. Proc Natl Acad Sci U S A 1994 Oct 11;91(21):10084-8

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:26108447 - Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast.

Hu L et al. Genes Cells 2015 Sep;20(9):695-705

PMID:7657164 - Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

Millar JB et al. Genes Dev 1995 Sep 01;9(17):2117-30

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:8256510 - Comparison of the biochemical and biological functions of tyrosine phosphatases from fission yeast, budding yeast and animal cells.

Hannig G et al. Yeast 1993 Oct;9(10):1039-52

PMID:24696293 - Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe.

Shimasaki T et al. Mol Genet Genomics 2014 Aug;289(4):685-93

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10233158 - Ssp1 promotes actin depolymerization and is involved in stress response and new end take-off control in fission yeast.

Rupes I et al. Mol Biol Cell 1999 May;10(5):1495-510

PMID:16087744 - Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe.

Rodríguez-Gabriel MA et al. Eukaryot Cell 2005 Aug;4(8):1396-402

PMID:17952063 - TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.

Petersen J et al. Nat Cell Biol 2007 Nov;9(11):1263-72

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

Verde F et al. J Cell Biol 1995 Dec;131(6 Pt 1):1529-38

PMID:1464319 - Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast.

Millar JB et al. EMBO J 1992 Dec;11(13):4943-52

PMID:9614178 - Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism.

Shiozaki K et al. Mol Biol Cell 1998 Jun;9(6):1339-49

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23687372 - New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress.

Martín R et al. J Cell Sci 2013 Jul 15;126(Pt 14):3010-20

PMID:31911490 - RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway.

Prieto-Ruiz F et al. mBio 2020 Jan 07;11(1)

PMID:25102102 - A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast.

Kim JY et al. Aging (Albany NY) 2014 Jul;6(7):587-601

PMID:23271606 - Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.

Ishiguro J et al. Mol Genet Genomics 2013 Feb;288(1-2):63-75

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22624651 - A systematic screen reveals new elements acting at the G2/M cell cycle control.

Navarro FJ et al. Genome Biol 2012 May 24;13(5):R36

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:1448087 - The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis.

Ottilie S et al. Mol Cell Biol 1992 Dec;12(12):5571-80

PMID:20075862 - Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway.

Zuin A et al. EMBO J 2010 Mar 03;29(5):981-91

PMID:33386485 - Spatial sequestration of misfolded proteins as an active chaperone-mediated process during heat stress.

Boronat S et al. Curr Genet 2021 Apr;67(2):237-243

PMID:27746023 - Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway.

Mutavchiev DR et al. Curr Biol 2016 Nov 07;26(21):2921-2928

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:1849659 - A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases.

Ottilie S et al. Proc Natl Acad Sci U S A 1991 Apr 15;88(8):3455-9

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:8649397 - Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.

Degols G et al. Mol Cell Biol 1996 Jun;16(6):2870-7

PMID:9560390 - Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast.

Humphrey T et al. Genetics 1998 Apr;148(4):1731-42

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:20453258 - Living on the edge: stress and activation of stress responses promote lifespan extension.

Zuin A et al. Aging (Albany NY) 2010 Apr;2(4):231-7

PMID:16143612 - Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.

Wang L et al. Genetics 2005 Dec;171(4):1523-33

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:10233152 - Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast.

Gaits F et al. Mol Biol Cell 1999 May;10(5):1395-407

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:8832414 - The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways.

Santo PD et al. J Cell Sci 1996 Jul;109 ( Pt 7)(0 7):1919-1925

PMID:11751918 - The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.

Taricani L et al. J Biol Chem 2002 Mar 22;277(12):10562-72

PMID:9832516 - Suppressors of cdc25p overexpression identify two pathways that influence the G2/M checkpoint in fission yeast.

Forbes KC et al. Genetics 1998 Dec;150(4):1361-75

PMID:19625445 - Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.

Núñez A et al. Mol Biol Cell 2009 Sep;20(18):3996-4009

PMID:8886983 - The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

Toda T et al. J Cell Sci 1996 Sep;109 ( Pt 9):2331-42

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:1464318 - Pyp3 PTPase acts as a mitotic inducer in fission yeast.

Millar JB et al. EMBO J 1992 Dec;11(13):4933-41

PMID:22661707 - A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities.

Zhou X et al. J Biol Chem 2012 Jul 06;287(28):23434-9

PMID:37572670 - A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms.

Cao M et al. Mol Cell 2023 Sep 07;83(17):3140-3154.e7

PMID:22912829 - Response to arsenate treatment in Schizosaccharomyces pombe and the role of its arsenate reductase activity.

Salgado A et al. PLoS One 2012;7(8):e43208

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:9154834 - Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe.

Degols G et al. Mol Cell Biol 1997 Jun;17(6):3356-63

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:15870269 - Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase.

Wang LY et al. Mol Cell Biol 2005 May;25(10):3945-55

PMID:9321395 - Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast.

Samejima I et al. EMBO J 1997 Oct 15;16(20):6162-70

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:33225241 - The Hsp40 Mas5 Connects Protein Quality Control and the General Stress Response through the Thermo-sensitive Pyp1.

Boronat S et al. iScience 2020 Nov 20;23(11):101725

PMID:41224899 - The zinc bound form of the actinomycete derived natural product compound JBIR-141 induces a mitotic phenotype in fission yeast.

Lewis RA et al. Sci Rep 2025 Nov 12;15(1):39721

PMID:32915139 - Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels.

Gómez-Gil E et al. Elife 2020 Sep 11;9

PMID:22139357 - H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4.

Di Y et al. EMBO J 2012 Feb 01;31(3):563-75

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:9211944 - Protein phosphatase 2C acts independently of stress-activated kinase cascade to regulate the stress response in fission yeast.

Gaits F et al. J Biol Chem 1997 Jul 11;272(28):17873-9

PMID:23934882 - Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.

Viana RA et al. Genetics 2013 Oct;195(2):421-32

PMID:12172965 - Identifying regulators of pheromone signalling in the fission yeast Schizosaccharomyces pombe.

Didmon M et al. Curr Genet 2002 Jul;41(4):241-53

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8