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protein coding gene - aif1 (SPAC26F1.14c) - mitochondrial inner membrane anchored oxidoreductase Aif1

Gene summary

Standard name
aif1
Systematic ID
SPAC26F1.14c
Product
mitochondrial inner membrane anchored oxidoreductase Aif1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC29A4.01c
UniProt ID
Q10499
ORFeome ID
35/35F12
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome I: 5146183..5148353 forward strand

Annotation

Disease association

MONDO:0010689 - Charcot-Marie-Tooth disease X-linked recessive 4

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MONDO:0010437 - severe X-linked mitochondrial encephalomyopathy

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MONDO:0010275 - spondyloepimetaphyseal dysplasia, Bieganski type

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MONDO:0010378 - X-linked hereditary sensory and autonomic neuropathy with hearing loss

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GO cellular component

GO:0005829 - cytosol

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GO:0005743 - mitochondrial inner membrane

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GO:0005634 - nucleus

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GO molecular function

GO:0051537 - 2 iron, 2 sulfur cluster binding

References:

GO:0016668 - oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

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GO:0016651 - oxidoreductase activity, acting on NAD(P)H

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Modification

MOD:00046 - O-phospho-L-serine

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00355RieskeRieske_2Fe-2SPFAM
PF14759Reductase_CReductase_CPFAM
PF07992Pyr_redox_2FAD/NAD-binding_domPFAM
cd03478Rieske_AIFL_NCDD
PS51296RIESKERieske_2Fe-2SPROSITE_PROFILES
PR00368FADPNRPRINTS
PR00411PNDRDTASEIPRINTS
SSF50022ISP domainRieske_2Fe-2S_sfSUPERFAMILY
SSF55424FAD/NAD-linked reductases, dimerisation (C-terminal) domainFAD/NAD-linked_Rdtase_dimer_sfSUPERFAMILY
SSF51905FAD/NAD(P)-binding domainFAD/NAD-bd_sfSUPERFAMILY
G3DSA:3.50.50.60FAD/NAD-bd_sfGENE3D
G3DSA:2.102.10.10Rieske_2Fe-2S_sfGENE3D
G3DSA:3.30.390.30FAD/NAD-linked_Rdtase_dimer_sfGENE3D
PTHR43557APOPTOSIS-INDUCING FACTOR 1FAD-oxidoreductase/ApoptosisPANTHER

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:36820394 - Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast.
Sanchez AM et al. MicroPubl Biol 2023;2023
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:23217327 - Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.
Rinaldi C et al. Am J Hum Genet 2012 Dec 07;91(6):1095-102
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:18223116 - Key function for the CCAAT-binding factor Php4 to regulate gene expression in response to iron deficiency in fission yeast.
Mercier A et al. Eukaryot Cell 2008 Mar;7(3):493-508
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:31892813 - Crosstalk between autophagy and apoptosis induced by camphor in Schizosaccharomyces pombe.
Ağuş HH et al. Turk J Biol 2019;43(6):382-390
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101