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protein coding gene - rpo41 (SPAC26H5.12) - mitochondrial RNA polymerase Rpo41

Gene summary

Standard name
rpo41
Systematic ID
SPAC26H5.12
Product
mitochondrial RNA polymerase Rpo41
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O13993
ORFeome ID
30/30D10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4147667..4151509 forward strand

Annotation

Disease association

MONDO:0859228 - combined oxidative phosphorylation deficiency 55

References:

GO biological process

GO:0006391 - transcription initiation at mitochondrial promoter

References:

GO cellular component

GO:0034245 - mitochondrial DNA-directed RNA polymerase complex

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0003899 - DNA-directed RNA polymerase activity

References:

GO:0001018 - mitochondrial promoter sequence-specific DNA binding

References:

Modification

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

Protein features

PBO:0111828 - PPR repeats

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000809 - abnormal mitochondrion organization

References:

Genotypes:

FYPO:0003423 - decreased mitochondrial RNA level

References:

Genotypes:

FYPO:0003424 - increased mitochondrial RNA level

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Genotypes:

FYPO:0003422 - inviable after spore germination, multiple cell divisions, elongated multiseptate tapered cell

References:

Genotypes:

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00940RNA_polDNA-dir_Rpol_C_phage-typePfam
PF14700RPOL_NRPOL_NPfam
PS00489RNA_POL_PHAGE_2DNA-dir_Rpol_phage-typePROSITE patterns
PS00900RNA_POL_PHAGE_1DNA-dir_Rpol_phage-typePROSITE patterns
SM01311RPOL_NRPOL_NSMART
G3DSA:1.10.1320.10:FF:000005CATH-FunFam
G3DSA:1.10.150.20:FF:000041CATH-FunFam
G3DSA:1.10.287.280:FF:000001CATH-FunFam
G3DSA:1.10.1320.10RNA_POL_N_sfCATH-Gene3D
G3DSA:1.10.150.20CATH-Gene3D
G3DSA:1.10.287.280CATH-Gene3D
SSF56672DNA/RNA_pol_sfSUPERFAMILY
PTHR10102DNA-dir_Rpol_phage-typePANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.
McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21357609 - Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe.
Jiang H et al. Nucleic Acids Res 2011 Jul;39(12):5119-30
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:21727087 - A genome wide study in fission yeast reveals nine PPR proteins that regulate mitochondrial gene expression.
Kühl I et al. Nucleic Acids Res 2011 Oct;39(18):8029-41
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:21138961 - A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1.
Sun W et al. Nucleic Acids Res 2011 Apr;39(7):2690-700
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105