protein coding gene - mei2 (SPAC27D7.03c) - RNA-binding protein involved in meiosis Mei2

Gene summary

Standard name

mei2

Systematic ID

SPAC27D7.03c

Product

RNA-binding protein involved in meiosis Mei2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P08965

ORFeome ID

33/33G01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4510983..4515025 reverse strand

Annotation

Protein features

Orthologs

• mei2 (SJAG_00145) Schizosaccharomyces japonicus

References / Literature

PMID:10835379 - Schizosaccharomyces pombe Ste7p is required for both promotion and withholding of the entry to meiosis.

Matsuyama A et al. Genetics 2000 Jun;155(2):539-49

PMID:11818066 - 14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p.

Sato M et al. Curr Biol 2002 Jan 22;12(2):141-5

PMID:28388826 - Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome.

Ohtsuka H et al. Mol Microbiol 2017 Jul;105(1):84-97

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:30089908 - Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization.

Vještica A et al. Nature 2018 Aug;560(7718):397-400

PMID:16478992 - Requirement of fission yeast Cid14 in polyadenylation of rRNAs.

Win TZ et al. Mol Cell Biol 2006 Mar;26(5):1710-21

PMID:31974447 - Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression.

Hazra D et al. Sci Rep 2020 Jan 23;10(1):1034

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:32361273 - Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe.

Stonyte V et al. iScience 2020 May 22;23(5):101063

PMID:25252312 - [Ash2, a subunit of histone H3K4 methyltransferase complex, is involved in the sporulation in Schizosaccharomyces pombe].

Wang W et al. Yi Chuan 2014 Sep;36(9):943-51

PMID:23843742 - Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.

Zhang MM et al. PLoS Biol 2013 Jul;11(7):e1001597

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.

Bednor L et al. mBio 2023 Dec 22;:e0306223

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:40185772 - A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors.

Leroy E et al. Nat Commun 2025 Apr 05;16(1):3250

PMID:41298081 - Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development.

Araoyinbo A et al. Genes Dev 2025 Nov 26;

PMID:20622014 - Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.

St-André O et al. J Biol Chem 2010 Sep 03;285(36):27859-68

PMID:19056896 - The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.

Helmlinger D et al. Genes Dev 2008 Nov 15;22(22):3184-95

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:3034608 - The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast.

McLeod M et al. EMBO J 1987 Mar;6(3):729-36

PMID:24920274 - Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1.

Shichino Y et al. Open Biol 2014 Jun;4(6):140022

PMID:3861929 - Characterization of meiosis-deficient mutants by electron microscopy and mapping of four essential genes in the fission yeast Schizosaccharomyces pombe.

Shimoda C et al. Mol Gen Genet 1985;200(2):252-7

PMID:15713656 - Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.

Kjaerulff S et al. Mol Cell Biol 2005 Mar;25(5):2045-59

PMID:1657594 - Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis.

DeVoti J et al. EMBO J 1991 Dec;10(12):3759-68

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:12808043 - The fission yeast meiotic regulator Mei2p forms a dot structure in the horse-tail nucleus in association with the sme2 locus on chromosome II.

Shimada T et al. Mol Biol Cell 2003 Jun;14(6):2461-9

PMID:23980030 - A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.

Yamashita A et al. Nucleic Acids Res 2013 Nov;41(21):9680-7

PMID:39105351 - A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast.

Ohtsuka H et al. Genes Cells 2024 Aug;29(8):667-680

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:33574613 - TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.

Wei Y et al. Nat Cell Biol 2021 Mar;23(3):243-256

PMID:39833200 - Centromere positioning orchestrates telomere bouquet formation and the initiation of meiotic differentiation.

Jiménez-Martín A et al. Nat Commun 2025 Jan 20;16(1):837

PMID:7862141 - The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.

Wu SY et al. Mol Cell Biol 1995 Mar;15(3):1479-88

PMID:28841135 - Ubiquitination-dependent control of sexual differentiation in fission yeast.

Simonetti F et al. Elife 2017 Aug 25;6

PMID:8557039 - Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase.

Takeda T et al. EMBO J 1995 Dec 15;14(24):6193-208

PMID:9778252 - RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast.

Yamashita A et al. Cell 1998 Oct 02;95(1):115-23

PMID:19620394 - Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Murai T et al. Genetics 2009 Oct;183(2):517-27

PMID:28476936 - Genome-wide screen for cell growth regulators in fission yeast.

Weston L et al. J Cell Sci 2017 Jun 15;130(12):2049-2055

PMID:11423126 - The fission yeast meiotic regulator Mei2p undergoes nucleocytoplasmic shuttling.

Sato M et al. FEBS Lett 2001 Jun 22;499(3):251-5

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:22144909 - The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Sukegawa Y et al. PLoS Genet 2011 Dec;7(12):e1002387

PMID:23813957 - The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters.

Nakase Y et al. J Cell Sci 2013 Sep 01;126(Pt 17):3972-81

PMID:16624901 - A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.

Nakase Y et al. Genetics 2006 Jun;173(2):569-78

PMID:9201720 - Ran1 functions to control the Cdc10/Sct1 complex through Puc1.

Caligiuri M et al. Mol Biol Cell 1997 Jun;8(6):1117-28

PMID:7520368 - S. pombe mei2+ encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA.

Watanabe Y et al. Cell 1994 Aug 12;78(3):487-98

PMID:10648609 - Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast.

Shinozaki-Yabana S et al. Mol Cell Biol 2000 Feb;20(4):1234-42

PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.

Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787

PMID:17046992 - Fission yeast Tor2 promotes cell growth and represses cell differentiation.

Alvarez B et al. J Cell Sci 2006 Nov 01;119(Pt 21):4475-85

PMID:33711009 - Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22.

Benjamin B et al. PLoS Genet 2021 Mar;17(3):e1009452

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.

Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819

PMID:3870979 - ran1+ controls the transition from mitotic division to meiosis in fission yeast.

Beach D et al. Curr Genet 1985;10(4):297-311

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:8832415 - The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

Stettler S et al. J Cell Sci 1996 Jul;109 ( Pt 7):1927-35

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:12723602 - Characterization of the Prr1 response regulator with special reference to sexual development in Schizosaccharomyces pombe.

Nakamichi N et al. Biosci Biotechnol Biochem 2003 Mar;67(3):547-55

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:24741065 - S. pombe TORC1 activates the ubiquitin-proteasomal degradation of the meiotic regulator Mei2 in cooperation with Pat1 kinase.

Otsubo Y et al. J Cell Sci 2014 Jun 15;127(Pt 12):2639-46

PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52

PMID:3025190 - Cloning and analysis of transcription of the mei2 gene responsible for initiation of meiosis in the fission yeast Schizosaccharomyces pombe.

Shimoda C et al. J Bacteriol 1987 Jan;169(1):93-6

PMID:33536434 - A scaffold lncRNA shapes the mitosis to meiosis switch.

Andric V et al. Nat Commun 2021 Feb 03;12(1):770

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:12827445 - Cordycepin in Schizosaccharomyces pombe: effects on the wild type and phenotypes of mutants resistant to the drug.

Naula N et al. Curr Genet 2003 Sep;43(6):400-6

PMID:28041796 - A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast.

Martín R et al. Curr Biol 2017 Jan 23;27(2):175-188

PMID:31811152 - Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe.

Ding DQ et al. Nat Commun 2019 Dec 06;10(1):5598

PMID:12664134 - Inactivation of Ran1/Pat1 kinase bypasses the requirement for high-level expression of mei2 during fission yeast meiosis.

Peng Z et al. Curr Genet 2003 Jun;43(3):178-85

PMID:36820394 - Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast.

Sanchez AM et al. MicroPubl Biol 2023;2023

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8

PMID:31533287 - meiRNA, A Polyvalent Player in Fission Yeast Meiosis.

Yamashita A Noncoding RNA 2019 Sep 17;5(3)

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:30257894 - mmi1 and rep2 mRNAs are novel RNA targets of the Mei2 RNA-binding protein during early meiosis in Schizosaccharomyces pombe .

Mukherjee K et al. Open Biol 2018 Sep 26;8(9)

PMID:10467002 - Gene ste20 controls amiloride sensitivity and fertility in Schizosaccharomyces pombe.

Hilti N et al. Curr Genet 1999 Jul;35(6):585-92

PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.

Seo HD et al. Curr Genet 2018 Jun;64(3):741-752

PMID:35512546 - Structural insights reveal the specific recognition of meiRNA by the Mei2 protein.

Shen S et al. J Mol Cell Biol 2022 Sep 19;14(5)

PMID:37772819 - Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase.

Sanchez AM et al. mBio 2023 Sep 29;14(5):e0205623

PMID:10788621 - Rad24 is essential for proliferation of diploid cells in fission yeast.

Tanaka Y et al. FEBS Lett 2000 Apr 28;472(2-3):254-8

PMID:9062192 - Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast.

Watanabe Y et al. Nature 1997 Mar 13;386(6621):187-90

PMID:20605454 - A gene-specific requirement of RNA polymerase II CTD phosphorylation for sexual differentiation in S. pombe.

Coudreuse D et al. Curr Biol 2010 Jun 22;20(12):1053-64

PMID:9167972 - Microtubule-associated coiled-coil protein Ssm4 is involved in the meiotic development in fission yeast.

Yamashita A et al. Genes Cells 1997 Feb;2(2):155-66

PMID:31276588 - Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.

Sanchez AM et al. Nucleic Acids Res 2019 Sep 19;47(16):8452-8469

PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.

Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:2840284 - The S.pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP.

Watanabe Y et al. EMBO J 1988 Mar;7(3):761-7

PMID:10835385 - Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

Mach KE et al. Genetics 2000 Jun;155(2):611-22

PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.

Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39

PMID:11702950 - Phosphorylation of Mei2 and Ste11 by Pat1 kinase inhibits sexual differentiation via ubiquitin proteolysis and 14-3-3 protein in fission yeast.

Kitamura K et al. Dev Cell 2001 Sep;1(3):389-99

PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.

Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:14745200 - Truncated Sla1 induces haploid meiosis through the Pat1-Mei2 system in fission yeast.

Tanabe K et al. Biosci Biotechnol Biochem 2004 Jan;68(1):266-70

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:37788281 - A dominant negative 14-3-3 mutant in Schizosaccharomyces pombe distinguishes the binding proteins involved in sexual differentiation and check point.

Ohshima T et al. PLoS One 2023;18(10):e0291524

PMID:38415071 - The Cdc14 phosphatase, Clp1, does not affect genome expression.

Lopez Maury L et al. MicroPubl Biol 2024;2024

PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.

Tsukahara K et al. Mol Cell Biol 1998 Aug;18(8):4488-98

PMID:8168486 - A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade.

Sugiyama A et al. EMBO J 1994 Apr 15;13(8):1881-7

PMID:1657709 - Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.

Sugimoto A et al. Genes Dev 1991 Nov;5(11):1990-9

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:16823445 - Selective elimination of messenger RNA prevents an incidence of untimely meiosis.

Harigaya Y et al. Nature 2006 Jul 06;442(7098):45-50