protein coding gene - mtl16 (SPAC27D7.08c) - 23S rRNA/U6 snRNA (adenine-N(6))-methyltransferase Mtl16

Gene summary

Standard name

mtl16

Systematic ID

SPAC27D7.08c

Product

23S rRNA/U6 snRNA (adenine-N(6))-methyltransferase Mtl16

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O42662

ORFeome ID

23/23H03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4521375..4523080 reverse strand

Annotation

Protein features

Orthologs

• METTL16 (HGNC:28484) Homo sapiens
• mtl16 (SJAG_01958) Schizosaccharomyces japonicus

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:40841561 - Structures and mechanisms of U6 snRNA m 6 A modification by METTL16.

Ju J et al. Nat Commun 2025 Aug 21;16(1):7708

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:37637271 - Isolation of mutant alleles of the U6 snRNA m 6 A methyltransferase Mtl16 and characterization of their genetic interactions with splicing mutants in Schizosaccharomyces pombe .

Willet AH et al. MicroPubl Biol 2023;2023

PMID:28525753 - The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.

Pendleton KE et al. Cell 2017 May 18;169(5):824-835.e14

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12