protein coding gene - cdc1 (SPAC27E2.05) - DNA polymerase delta small subunit Cdc1

Gene summary

Standard name

cdc1

Systematic ID

SPAC27E2.05

Product

DNA polymerase delta small subunit Cdc1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

mis1

UniProt ID

P87324

ORFeome ID

23/23B11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 4015050..4016557 forward strand

Annotation

Protein features

Orthologs

• POLD2 (HGNC:9176) Homo sapiens
• cdc1 (SJAG_04877) Schizosaccharomyces japonicus
• POL31 (YJR006W) Saccharomyces cerevisiae

References / Literature

PMID:9326594 - DNA polymerase delta isolated from Schizosaccharomyces pombe contains five subunits.

Zuo S et al. Proc Natl Acad Sci U S A 1997 Oct 14;94(21):11244-9

PMID:10704216 - In vitro reconstitution of the Schizosaccharomyces pombe alternative excision repair pathway.

Alleva JL et al. Biochemistry 2000 Mar 14;39(10):2659-66

PMID:9383050 - Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.

Forsburg SL et al. Genetics 1997 Nov;147(3):1025-41

PMID:15173383 - The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit.

Sanchez Garcia J et al. Nucleic Acids Res 2004;32(10):3005-16

PMID:8292390 - A novel mutation involved in the mitotic checkpoint in the fission yeast Schizosaccharomyces pombe.

Ishiguro J et al. Jpn J Genet 1993 Aug;68(4):265-76

PMID:21389117 - Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.

Kimata Y et al. Mol Biol Cell 2011 May;22(9):1486-94

PMID:17112379 - The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.

Locovei AM et al. Cell Div 2006 Nov 17;1:27

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:9799358 - Cdm1, the smallest subunit of DNA polymerase d in the fission yeast Schizosaccharomyces pombe, is non-essential for growth and division.

Reynolds N et al. Curr Genet 1998 Oct;34(4):250-8

PMID:23211746 - Initiation of DNA damage responses through XPG-related nucleases.

Kuntz K et al. EMBO J 2013 Jan 23;32(2):290-302

GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:10671561 - Structure and activity associated with multiple forms of Schizosaccharomyces pombe DNA polymerase delta.

Zuo S et al. J Biol Chem 2000 Feb 18;275(7):5153-62

PMID:16453724 - Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

Hirano T et al. EMBO J 1986 Nov;5(11):2973-9

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10888871 - Mitotic replication initiation proteins are not required for pre-meiotic S phase.

Forsburg SL et al. Nat Genet 2000 Jul;25(3):263-8

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:7845361 - Ethanol-hypersensitive and ethanol-dependent cdc- mutants in Schizosaccharomyces pombe.

Jimenez J et al. Mol Gen Genet 1994 Oct 17;245(1):86-95

PMID:10683155 - A novel mutant allele of the chromatin-bound fission yeast checkpoint protein Rad17 separates the DNA structure checkpoints.

Griffiths D et al. J Cell Sci 2000 Mar;113 ( Pt 6):1075-88

PMID:33796794 - Increased expression of Polδ does not alter the canonical replication program in vivo .

Zach R et al. Wellcome Open Res 2021;6:44

PMID:10880469 - Genetic analyses of Schizosaccharomyces pombe dna2(+) reveal that dna2 plays an essential role in Okazaki fragment metabolism.

Kang HY et al. Genetics 2000 Jul;155(3):1055-67

PMID:19686603 - Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis.

Sanchez Garcia J et al. BMC Mol Biol 2009 Aug 17;10:82

PMID:10748208 - Fidelity of eucaryotic DNA polymerase delta holoenzyme from Schizosaccharomyces pombe.

Chen X et al. J Biol Chem 2000 Jun 09;275(23):17677-82

PMID:16040599 - Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast.

Kim J et al. Nucleic Acids Res 2005;33(13):4078-89

PMID:24462781 - RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe.

Smialowska A et al. Biochem Biophys Res Commun 2014 Feb 07;444(2):254-9

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:7865880 - Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.

Takahashi K et al. Mol Biol Cell 1994 Oct;5(10):1145-58

PMID:10757807 - Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated.

Wang SW et al. Mol Cell Biol 2000 May;20(9):3234-44

PMID:12697806 - Replication proteins influence the maintenance of telomere length and telomerase protein stability.

Dahlén M et al. Mol Cell Biol 2003 May;23(9):3031-42

PMID:10698951 - Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21(Cip1)-like PCNA binding motif.

Reynolds N et al. EMBO J 2000 Mar 01;19(5):1108-18

PMID:15579205 - Mapping and mutation of the conserved DNA polymerase interaction motif (DPIM) located in the C-terminal domain of fission yeast DNA polymerase delta subunit Cdc27.

Gray FC et al. BMC Mol Biol 2004 Dec 03;5(1):21

PMID:1934126 - Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.

Grallert B et al. Curr Genet 1991 Aug;20(3):199-204

PMID:8887553 - The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27.

MacNeill SA et al. EMBO J 1996 Sep 02;15(17):4613-28

PMID:958201 - Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.

Nurse P et al. Mol Gen Genet 1976 Jul 23;146(2):167-78

PMID:12124382 - The influence of the Cdc27 subunit on the properties of the Schizosaccharomyces pombe DNA polymerase delta.

Bermudez VP et al. J Biol Chem 2002 Sep 27;277(39):36853-62

PMID:6828164 - Control of timing of cell cycle events in fission yeast by the wee 1+ gene.

Fantes PA Nature 1983 Mar 10;302(5904):153-5

PMID:9891047 - Mutator phenotype induced by aberrant replication.

Liu VF et al. Mol Cell Biol 1999 Feb;19(2):1126-35

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

GO_REF:0000051 - S. pombe keyword mapping

GO_REF:0000002 - Comments

PMID:10388806 - Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.

Snaith HA et al. Genetics 1999 Jul;152(3):839-51