PomBase home

protein coding gene - msm1 (SPAC27E2.06c) - mitochondrial methionine-tRNA ligase Msm1

Gene summary

Standard name
msm1
Systematic ID
SPAC27E2.06c
Product
mitochondrial methionine-tRNA ligase Msm1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14000
ORFeome ID
25/25H08
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 4016534..4018388 reverse strand

Annotation

Disease association

MONDO:0014636 - combined oxidative phosphorylation defect type 25

References:

MONDO:0012664 - spastic ataxia 3

References:

GO biological process

GO:0032543 - mitochondrial translation

References:

GO:0043039 - tRNA charging

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0004825 - methionine-tRNA ligase activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF09334tRNA-synt_1gMethionyl/Leucyl_tRNA_SynthPfam
cd00814MetRS_coreMetRS_coreCDD
PR01041TRNASYNTHMETMetRS_corePRINTS
G3DSA:2.170.220.10:FF:000001CATH-FunFam
G3DSA:1.10.730.10CATH-Gene3D
G3DSA:2.170.220.10CATH-Gene3D
G3DSA:3.40.50.620Rossmann-like_a/b/a_foldCATH-Gene3D
SSF47323tRNAsynth_Ia_anticodon-bdSUPERFAMILY
SSF52374SUPERFAMILY
PTHR43326Met-tRNA_synth_2PANTHER
TIGR00398metGMet-tRNA_synthNCBIFAM

Orthologs

References / Literature

GO_REF:0000051 - S. pombe keyword mapping
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83