protein coding gene - uch1 (SPAC27F1.03c) - ubiquitin C-terminal hydrolase Uch1

Gene summary

Standard name: uch1
Systematic ID: SPAC27F1.03c
Product: ubiquitin C-terminal hydrolase Uch1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q10171
ORFeome ID: 42/42H03
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 4320716..4321526 reverse strand

Annotation

GO biological process

GO:0000338 - protein deneddylation

References:

PMID:23496905

GO:0006511 - ubiquitin-dependent protein catabolic process

References:

GO_REF:0000002

GO cellular component

GO:0005737 - cytoplasm

References:

PMID:20838651

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

GO molecular function

GO:0004843 - cysteine-type deubiquitinase activity

References:

GO_REF:0000033

GO:0019784 - deNEDDylase activity

References:

PMID:23496905

GO:0140492 - metal-dependent deubiquitinase activity

References:

PMID:20838651

Multi-locus phenotype

FYPO:0005822 - decreased NEDD8-specific protease activity

References:

PMID:23496905

Genotypes:

FYPO:0005818 - normal protein neddylation

References:

PMID:23496905

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

PMID:23496905

Genotypes:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0001023 - normal growth on cisplatin

References:

PMID:21247416

Genotypes:

uch1delta

FYPO:0005818 - normal protein neddylation

References:

PMID:23496905

Genotypes:

uch1delta

FYPO:0009038 - resistance to egtazic acid

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0001034 - resistance to tunicamycin

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0009069 - sensitive to ciclopirox olamine

References:

PMID:37787768

Genotypes:

uch1delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

uch1delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

uch1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF01088	Peptidase_C12	Peptidase_C12_UCH	PFAM
cd09616	Peptidase_C12_UCH_L1_L3		CDD
PS00140	UCH_1	UCH_AS	PROSITE_PATTERNS
PS52048	UCH_DOMAIN	Peptidase_C12_UCH	PROSITE_PROFILES
PR00707	UBCTHYDRLASE	Peptidase_C12_UCH	PRINTS
SSF54001	Cysteine proteinases	Papain-like_cys_pep_sf	SUPERFAMILY
G3DSA:3.40.532.10		Peptidase_C12_UCH_sf	GENE3D
PTHR10589	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE	Peptidase_C12_UCH	PANTHER

Orthologs

UCHL3 (HGNC:12515) Homo sapiens
uch1 (SJAG_00795) Schizosaccharomyces japonicus
YUH1 (YJR099W) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21247416 - Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.: Gatti L et al. BMC Genomics 2011 Jan 19;12:44
PMID:23496905 - Nedd8 processing enzymes in Schizosaccharomyces pombe.: O'Donoghue JE et al. BMC Biochem 2013 Mar 15;14:8
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.: Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:20838651 - A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.: Kouranti I et al. PLoS Biol 2010 Sep 07;8(9)
GO_REF:0000002 - Comments