protein coding gene - cam2 (SPAC29A4.05) - myosin I light chain Cam2

Gene summary

Standard name

cam2

Systematic ID

SPAC29A4.05

Product

myosin I light chain Cam2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O14008

ORFeome ID

03/03E11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 5137314..5138153 reverse strand

Annotation

Protein features

Orthologs

• CALM1 (HGNC:1442) Homo sapiens
• CALM2 (HGNC:1445) Homo sapiens
• CALM3 (HGNC:1449) Homo sapiens
• CALML3 (HGNC:1452) Homo sapiens
• CALML5 (HGNC:18180) Homo sapiens
• CALML4 (HGNC:18445) Homo sapiens
• cam2 (SJAG_04781) Schizosaccharomyces japonicus

References / Literature

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:17202724 - Localization of type I myosin and F-actin to the leading edge region of the forespore membrane in Schizosaccharomyces pombe.

Itadani A et al. Cell Struct Funct 2006;31(2):181-95

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:25825517 - A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.

Dudin O et al. J Cell Biol 2015 Mar 30;208(7):897-911

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:37815455 - Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesis.

Willet AH et al. J Cell Sci 2023 Nov 01;136(21)

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:37531259 - Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins.

Willet AH et al. Mol Biol Cell 2023 Oct 01;34(11):br17

PMID:15504913 - UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.

Lord M et al. J Cell Biol 2004 Oct 25;167(2):315-25

PMID:28292899 - Fission yeast myosin I facilitates PI(4,5)P 2 -mediated anchoring of cytoplasmic dynein to the cortex.

Thankachan JM et al. Proc Natl Acad Sci U S A 2017 Mar 28;114(13):E2672-E2681

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:21693583 - A calmodulin-related light chain from fission yeast that functions with myosin-I and PI 4-kinase.

Sammons MR et al. J Cell Sci 2011 Jul 15;124(Pt 14):2466-77

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72