protein coding gene - srb6 (SPAC29A4.07) - mediator complex subunit Med22

Gene summary

Standard name: srb6
Systematic ID: SPAC29A4.07
Product: mediator complex subunit Med22
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: med22
UniProt ID: O14010
ORFeome ID: 03/03C01
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome I: 5133784..5136019 reverse strand

Annotation

GO biological process

GO:0060261 - positive regulation of transcription initiation by RNA polymerase II

References:

PMID:28467824

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

PMID:15182371

GO cellular component

GO:0016592 - mediator complex

References:

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0005515 - protein binding

References:

PMID:23123849

GO:0003713 - transcription coactivator activity

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002463 - inviable branched, curved, elongated vegetative cell

References:

PMID:23697806

Genotypes:

srb6delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

srb6delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF06179	Med22	Med22	PFAM
G3DSA:6.10.280.160	Mediator of RNA polymerase II transcription subunit 22		GENE3D
PTHR12434	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22	Med22	PANTHER

Orthologs

MED22 (HGNC:11477) Homo sapiens
srb6 (SJAG_05341) Schizosaccharomyces japonicus
SRB6 (YBR253W) Saccharomyces cerevisiae

References / Literature

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28467824 - Core Mediator structure at 3.4 Å extends model of transcription initiation complex.: Nozawa K et al. Nature 2017 May 11;545(7653):248-251
PMID:15182371 - Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.: Tamayo E et al. Eur J Biochem 2004 Jun;271(12):2561-72
PMID:10625684 - Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe.: Spåhr H et al. J Biol Chem 2000 Jan 14;275(2):1351-6
PMID:28241144 - Mediator structure and rearrangements required for holoenzyme formation.: Tsai KL et al. Nature 2017 Apr 13;544(7649):196-201
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23123849 - Structure of the Mediator head module.: Larivière L et al. Nature 2012 Dec 20;492(7429):448-51
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6