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protein coding gene - ure6 (SPAC29A4.13) - urease accessory protein UreF

Gene summary

Standard name
ure6
Systematic ID
SPAC29A4.13
Product
urease accessory protein UreF
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14016
ORFeome ID
08/08D05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5120840..5122098 reverse strand

Annotation

GO biological process

GO:0019627 - urea metabolic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005730 - nucleolus

References:

GO:0150006 - urease activator complex

References:

GO molecular function

GO:0016151 - nickel cation binding

References:

GO:0018237 - urease activator activity

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003642 - abnormal urease activity

References:

Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Warnings

PBO:0001756 - protein coding overlap with adjacent gene

Protein features

IDNameInterPro nameDB name
PF01730UreFUreFPFAM
G3DSA:1.10.4190.10Urease accessory protein UreFUreF_sfGENE3D
PTHR33620UREASE ACCESSORY PROTEIN FPANTHER
PIRSF009467Urease_acces_UreFUreFPIRSF

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
GO_REF:0000002 - Comments
PMID:26037463 - Functional expression of a heterologous nickel-dependent, ATP-independent urease in Saccharomyces cerevisiae.
Milne N et al. Metab Eng 2015 Jul;30:130-140
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:12471450 - Activation of the urease of Schizosaccharomyces pombe by the UreF accessory protein from soybean.
Bacanamwo M et al. Mol Genet Genomics 2002 Dec;268(4):525-34
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:24115911 - Structure of UreG/UreF/UreH complex reveals how urease accessory proteins facilitate maturation of Helicobacter pylori urease.
Fong YH et al. PLoS Biol 2013 Oct;11(10):e1001678
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053