protein coding gene - srs1 (SPAC29A4.15) - cytoplasmic serine-tRNA ligase Srs1

Gene summary

Standard name: srs1
Systematic ID: SPAC29A4.15
Product: cytoplasmic serine-tRNA ligase Srs1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O14018
ORFeome ID: 44/44C09
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 5117470..5119053 reverse strand

Annotation

Disease association

MONDO:0019502 - autosomal recessive non-syndromic intellectual disability

References:

PB_REF:0000003

MONDO:0060577 - neurodevelopmental disorder with microcephaly, ataxia, and seizures

References:

PB_REF:0000006

GO biological process

GO:0002181 - cytoplasmic translation

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO molecular function

GO:0005524 - ATP binding

References:

GO_REF:0000002

GO:0004828 - serine-tRNA ligase activity

References:

GO_REF:0000033

GO:0000049 - tRNA binding

References:

GO_REF:0000033

Modification

MOD:00595 - monomannosylated residue

References:

PMID:26644575

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

PMID:30726745

MOD:00048 - O4'-phospho-L-tyrosine

References:

PMID:30726745

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39705284

PomGeneEx:0000012 - RNA level decreased

References:

PMID:27984744

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

srs1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

srs1delta

FYPO:0006680 - sensitive to bisphenol A

References:

PMID:30099677

Genotypes:

srs1delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00587	tRNA-synt_2b	aa-tRNA-synt_IIb	PFAM
PF02403	Seryl_tRNA_N	Ser-tRNA-synth_1_N	PFAM
cd00770	SerRS_core	SerRS_core	CDD
PS50862	AA_TRNA_LIGASE_II	aa-tRNA-synth_II	PROSITE_PROFILES
PR00981	TRNASYNTHSER	Ser-tRNA-ligase_type_1	PRINTS
G3DSA:3.30.930.10:FF:000026			FUNFAM
G3DSA:1.10.287.40:FF:000003			FUNFAM
SSF55681	Class II aaRS and biotin synthetases	aa-tRNA-synth_II/BPL/LPL	SUPERFAMILY
SSF46589	tRNA-binding arm	tRNA-bd_arm	SUPERFAMILY
G3DSA:3.30.930.10	Bira Bifunctional Protein; Domain 2	aa-tRNA-synth_II/BPL/LPL	GENE3D
G3DSA:1.10.287.40		SerRS_1_N_sf	GENE3D
PTHR11778	SERYL-TRNA SYNTHETASE	Ser-tRNA-ligase_type_1	PANTHER
PIRSF001529	Ser-tRNA_ligase	Ser-tRNA-ligase_type_1	PIRSF
Coil	Coil		COILS
TIGR00414	serS	Ser-tRNA-ligase_type_1	NCBIFAM

Orthologs

SARS1 (HGNC:10537) Homo sapiens
srs1 (SJAG_04762) Schizosaccharomyces japonicus
SES1 (YDR023W) Saccharomyces cerevisiae

References / Literature

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:30099677 - Genome-wide evidences of bisphenol a toxicity using Schizosaccharomyces pombe.: Kim DM et al. Arch Pharm Res 2018 Aug;41(8):830-837
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.: Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.: Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:22540037 - Predicting the fission yeast protein interaction network.: Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000002 - Comments
PB_REF:0000003 - Disease Association Curation
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.: Larochelle M et al. J Cell Sci 2019 May 31;132(11)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.: Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.: Calvo IA et al. iScience 2021 Nov 19;24(11):103338