protein coding gene - prw1 (SPAC29A4.18) - histone chaperone, Clr6 and Rpd3L complex WD repeat subunit Prw1

Gene summary

Standard name

prw1

Systematic ID

SPAC29A4.18

Product

histone chaperone, Clr6 and Rpd3L complex WD repeat subunit Prw1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O14021

ORFeome ID

23/23C03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 5110278..5111882 reverse strand

Annotation

Protein features

Orthologs

• RBBP4 (HGNC:9887) Homo sapiens
• RBBP7 (HGNC:9890) Homo sapiens
• prw1 (SJAG_04758) Schizosaccharomyces japonicus
• WTM2 (YOR229W) Saccharomyces cerevisiae
• WTM1 (YOR230W) Saccharomyces cerevisiae
• UME1 (YPL139C) Saccharomyces cerevisiae

References / Literature

PMID:19040720 - Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Shevchenko A et al. Genome Biol 2008;9(11):R167

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:25002536 - A novel histone deacetylase complex in the control of transcription and genome stability.

Zilio N et al. Mol Cell Biol 2014 Sep 15;34(18):3500-14

PMID:12773392 - Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity.

Nakayama J et al. EMBO J 2003 Jun 02;22(11):2776-87

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:37076472 - Two assembly modes for SIN3 histone deacetylase complexes.

Wang C et al. Cell Discov 2023 Apr 19;9(1):42

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:33130996 - Expression of the Neural REST/NRSF-SIN3 Transcriptional Corepressor Complex as a Target for Small-Molecule Inhibitors.

Jayaprakash S et al. Mol Biotechnol 2021 Jan;63(1):53-62

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:17450151 - Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection.

Nicolas E et al. Nat Struct Mol Biol 2007 May;14(5):372-80

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:20404084 - Transcriptional activation of the general amino acid permease gene per1 by the histone deacetylase Clr6 Is regulated by Oca2 kinase.

Kaufmann I et al. Mol Cell Biol 2010 Jul;30(13):3396-410

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhou X et al. PLoS One 2013;8(5):e65904

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:38048463 - Rex1BD and the 14-3-3 protein control heterochromatin organization at tandem repeats by linking RNAi and HDAC.

Gao J et al. Proc Natl Acad Sci U S A 2023 Dec 12;120(50):e2309359120

PMID:37459529 - Class I histone deacetylase complex: Structure and functional correlates.

Wang X et al. Proc Natl Acad Sci U S A 2023 Jul 25;120(30):e2307598120

PMID:33468217 - Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.

Weigt M et al. Epigenetics Chromatin 2021 Jan 19;14(1):8

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6