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protein coding gene - cta5 (SPAC29A4.19c) - P-type ATPase P5 type Cta5

Gene summary

Standard name
cta5
Systematic ID
SPAC29A4.19c
Product
P-type ATPase P5 type Cta5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14022
ORFeome ID
48/48C07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 5106559..5113025 forward strand

Annotation

Disease association

MONDO:0014975 - autosomal recessive spastic paraplegia type 78

References:

MONDO:0011706 - Kufor-Rakeb syndrome

References:

MONDO:0005071 - nervous system disorder

References:

MONDO:0009935 - pulmonary hypertension, primary, 5

References:

GO biological process

GO:0006874 - intracellular calcium ion homeostasis

References:

GO:0098655 - monoatomic cation transmembrane transport

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GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO:0005794 - Golgi apparatus

References:

GO:0000139 - Golgi membrane

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GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0140358 - P-type transmembrane transporter activity

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001020 - normal growth on calcium

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0000092 - sensitive to amiodarone

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Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0000286 - sensitive to manganese depletion

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

Protein sequence feature

SO:0001812 - transmembrane_helix

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000636 - increased cell population growth rate

References:

Genotypes:

FYPO:0008456 - normal plasma membrane hypoosmotic expansion during vegetative growth

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00122E1-E2_ATPaseATPase_P-type_domAPFAM
PF00690Cation_ATPase_NATPase_P-typ_cation-transptr_NPFAM
PF13246Cation_ATPasePFAM
PF12409P5-ATPaseP5A-ATPase_NPFAM
PS01229COF_2PROSITE_PATTERNS
PS00154ATPASE_E1_E2ATPase_P-typ_P_sitePROSITE_PATTERNS
PR00119CATATPASEPRINTS
SSF81660Metal cation-transporting ATPase, ATP-binding domain NATPase_P-typ_cyto_dom_NSUPERFAMILY
SSF56784HAD-likeHAD-like_sfSUPERFAMILY
SSF81665Calcium ATPase, transmembrane domain MATPase_P-typ_TM_dom_sfSUPERFAMILY
SSF81653Calcium ATPase, transduction domain AATPase_P-typ_transduc_dom_A_sfSUPERFAMILY
G3DSA:2.70.150.10GENE3D
G3DSA:3.40.50.1000HAD_sfGENE3D
G3DSA:1.20.1110.10GENE3D
G3DSA:3.40.1110.10ATPase_P-typ_cyto_dom_NGENE3D
PTHR45630CATION-TRANSPORTING ATPASE-RELATEDP-type_TPase_VPANTHER
TIGR01657P-ATPase-VP-type_TPase_VNCBIFAM
TIGR01494ATPase_P-typeP_typ_ATPaseNCBIFAM
SFLDS00003Haloacid_DehalogenaseSFLD
SFLDF00027p-type_atpaseP_typ_ATPase_HD_domSFLD
SFLDG00002C1.7:_P-type_atpase_likeSFLD

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40629316 - Ca 2+ -dependent vesicular and non-vesicular lipid transfer controls hypoosmotic plasma membrane expansion.
Mu B et al. BMC Biol 2025 Jul 09;23(1):207
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:31201205 - Coordinated Roles of the Putative Ceramide-Conjugation Protein, Cwh43, and a Mn 2+ -Transporting, P-Type ATPase, Pmr1, in Fission Yeast.
Nakazawa N et al. G3 (Bethesda) 2019 Aug 08;9(8):2667-2676
PMID:19168988 - Characterization of a fission yeast P(5)-type ATPase homologue that is essential for Ca(2+)/Mn(2+ )homeostasis in the absence of P(2)-type ATPases.
Furune T et al. Genes Genet Syst 2008 Oct;83(5):373-81
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22442086 - Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity.
Usenovic M et al. J Neurosci 2012 Mar 21;32(12):4240-6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
GO_REF:0000033 - Annotation inferences using phylogenetic trees