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protein coding gene - hot13 (SPAC29B12.12) - helper of TIM Hot13

Gene summary

Standard name
hot13
Systematic ID
SPAC29B12.12
Product
helper of TIM Hot13
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14033
ORFeome ID
02/02A11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 5438212..5438553 forward strand

Annotation

GO biological process

GO:0045041 - protein import into mitochondrial intermembrane space

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GO cellular component

GO:0005758 - mitochondrial intermembrane space

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GO molecular function

GO:0008270 - zinc ion binding

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Modification

MOD:00595 - monomannosylated residue

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Protein features

PBO:0111891 - zf-CHY

PBO:0111743 - zinc finger protein

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009036 - resistance to benzamidine

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0005193 - resistance to torin1

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Genotypes:

FYPO:0000830 - resistance to vanadate

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FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF05495zf-CHYZnf_CHYPFAM
PS00478LIM_DOMAIN_1Znf_LIMPROSITE_PATTERNS
PS51266ZF_CHYZnf_CHYPROSITE_PROFILES
SSF161219CHY zinc finger-likeZnf_CHY_sfSUPERFAMILY
PTHR28082ZINC FINGER PROTEINMito_Tim_assembly_helperPANTHER
PIRSF017292UCP017292_znUCP017292PIRSF

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12