protein coding gene - uso1 (SPAC29E6.03c) - ER to Golgi tether Uso1

Gene summary

Standard name: uso1
Systematic ID: SPAC29E6.03c
Product: ER to Golgi tether Uso1
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPAC30.07c
UniProt ID: Q09857
ORFeome ID: 48/48D02
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 4405990..4409370 reverse strand

Annotation

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO_REF:0000033

GO:0006886 - intracellular protein transport

References:

GO_REF:0000033

GO:0048280 - vesicle fusion with Golgi apparatus

References:

GO_REF:0000002

GO cellular component

GO:0005789 - endoplasmic reticulum membrane

References:

GO_REF:0000024

GO:0012507 - ER to Golgi transport vesicle membrane

References:

GO_REF:0000033

GO:0000139 - Golgi membrane

References:

GO_REF:0000024

GO:0005795 - Golgi stack

References:

GO_REF:0000033

GO molecular function

GO:7770062 - vesicle membrane tethering activity

References:

PMID:15979505

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

PMID:30726745

MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111894 - armadillo repeat protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

References:

PMID:23697806

Genotypes:

uso1delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

uso1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

uso1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000108 - frameshifted

References:

PMID:26615217

PBO:0091544 - I:4407494_4407495insG

References:

PMID:26615217

PBO:0000129 - sequence error in genomic data

References:

PMID:26615217

Protein features

ID	Name	InterPro name	DB name
PF04869	Uso1_p115_head	Vesicle_Uso1_P115_head	PFAM
SSF48371	ARM repeat	ARM-type_fold	SUPERFAMILY
G3DSA:1.10.287.1490			GENE3D
G3DSA:1.25.10.10		ARM-like	GENE3D
PTHR10013	GENERAL VESICULAR TRANSPORT FACTOR P115	Vesicle_P115	PANTHER
Coil	Coil		COILS
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte

Orthologs

USO1 (HGNC:30904) Homo sapiens
uso1 (SJAG_01633) Schizosaccharomyces japonicus
USO1 (YDL058W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000002 - Comments
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:15979505 - Golgi tethering factors.: Lupashin V et al. Biochim Biophys Acta 2005 Jul 10;1744(3):325-39
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26615217 - Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.: Hu W et al. Genome Biol Evol 2015 Nov 27;7(12):3496-510
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)