PomBase home

protein coding gene - mxr1 (SPAC29E6.05c) - peptide-methionine (S)-S-oxide reductase MsrA

Gene summary

Standard name
mxr1
Systematic ID
SPAC29E6.05c
Product
peptide-methionine (S)-S-oxide reductase MsrA
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
MsrA, SPAC30.09c
UniProt ID
Q09859
ORFeome ID
06/06A03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4409678..4411226 reverse strand

Annotation

GO biological process

GO:0034599 - cellular response to oxidative stress

References:

GO:0030091 - protein repair

References:

GO:0110052 - toxic metabolite repair

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0033744 - L-methionine (S)-S-oxide reductase activity

References:

GO:0008113 - peptide-methionine (S)-S-oxide reductase activity

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0001237 - normal growth on cadmium

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0001240 - normal growth on diamide

References:

Genotypes:

FYPO:0003274 - normal growth on GSNO

References:

Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

References:

Genotypes:

FYPO:0002691 - normal growth on menadione

References:

Genotypes:

FYPO:0003273 - normal growth on nitrite

References:

Genotypes:

FYPO:0003272 - normal growth on sodium hypochlorite

References:

Genotypes:

FYPO:0001310 - normal viability in stationary phase

References:

Genotypes:

FYPO:0009066 - resistance to amorolfine

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0001450 - resistance to cold

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001453 - resistance to ethanol

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0007808 - resistance to valproic acid

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01625PMSRMet_Sox_Rdtase_MsrA_domPfam
G3DSA:3.30.1060.10:FF:000006CATH-FunFam
G3DSA:3.30.1060.10Met_Sox_Rdtase_MsrA_sfCATH-Gene3D
SSF55068Met_Sox_Rdtase_MsrA_sfSUPERFAMILY
PTHR43774PANTHER
TIGR00401msrAMet_Sox_Rdtase_MsrA_domNCBIFAM
MF_01401MsrAMet_Sox_Rdtase_MsrA_domHAMAP

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22245228 - Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
Day AM et al. Mol Cell 2012 Feb 10;45(3):398-408
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24118096 - Methionine sulphoxide reductases revisited: free methionine as a primary target of H₂O₂stress in auxotrophic fission yeast.
García-Santamarina S et al. Mol Microbiol 2013 Dec;90(5):1113-24