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protein coding gene - tbp1 (SPAC29E6.08) - TATA-binding protein (TBP)

Gene summary

Standard name
tbp1
Systematic ID
SPAC29E6.08
Product
TATA-binding protein (TBP)
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
tdf1, tbp, SPAC30.12
UniProt ID
P17871
ORFeome ID
43/43G03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 4415479..4417151 forward strand

Annotation

Complementation

PBO:0091547 - functionally complements S. cerevisiae SPT15

References:

Disease association

MONDO:0008199 - late-onset Parkinson disease

References:

MONDO:0011781 - spinocerebellar ataxia type 17

References:

GO biological process

GO:0006361 - transcription initiation at RNA polymerase I promoter

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

GO:0006384 - transcription initiation at RNA polymerase III promoter

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GO cellular component

GO:0005634 - nucleus

References:

GO:0000120 - RNA polymerase I transcription regulator complex

References:

GO:0005669 - transcription factor TFIID complex

References:

GO:0000126 - transcription factor TFIIIB complex

References:

GO molecular function

GO:0001181 - RNA polymerase I general transcription initiation factor activity

References:

GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding

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GO:0016251 - RNA polymerase II general transcription initiation factor activity

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GO:0000995 - RNA polymerase III general transcription initiation factor activity

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GO:0001006 - RNA polymerase III type 3 promoter sequence-specific DNA binding

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Modification

MOD:01149 - sumoylated lysine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0007639 - increased DNA damage at rDNA during G0

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Genotypes:

FYPO:0004032 - increased protein localization to chromatin at rDNA

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Genotypes:

FYPO:0000944 - inviable spore with normal morphology

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0007629 - normal viability during G0

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Genotypes:

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0007642 - decreased histone H3-K9 dimethylation at rDNA during G0

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00352TBPTBPPFAM
cd04516TBP_eukaryotesTBP_eukaryoticCDD
PS00351TFIIDTBP_CSPROSITE_PATTERNS
PR00686TIFACTORIIDTBPPRINTS
G3DSA:3.30.310.10:FF:000002FUNFAM
G3DSA:3.30.310.10:FF:000001FUNFAM
SSF55945TATA-box binding protein-likeSUPERFAMILY
G3DSA:3.30.310.10TBP_dom_sfGENE3D
PTHR10126TATA-BOX BINDING PROTEINTBPPANTHER
MF_00408TATA_bind_prot_archTBPHAMAP

Orthologs

References / Literature

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:2197558 - Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae.
Fikes JD et al. Nature 1990 Jul 19;346(6281):291-4
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:30810475 - Early splicing functions of fission yeast Prp16 and its unexpected requirement for gene Silencing is governed by intronic features.
Vijayakumari D et al. RNA Biol 2019 Jun;16(6):754-769
PMID:9092673 - An immunoaffinity purified Schizosaccharomyces pombe TBP-containing complex directs correct initiation of the S.pombe rRNA gene promoter.
Chen L et al. Nucleic Acids Res 1997 Apr 15;25(8):1633-40
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:12565823 - The kic1 kinase of schizosaccharomyces pombe is a CLK/STY orthologue that regulates cell-cell separation.
Tang Z et al. Exp Cell Res 2003 Feb 01;283(1):101-15
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:2210373 - Cloning of the Schizosaccharomyces pombe TFIID gene reveals a strong conservation of functional domains present in Saccharomyces cerevisiae TFIID.
Hoffmann A et al. Genes Dev 1990 Jul;4(7):1141-8
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:11279037 - Two WD repeat-containing TATA-binding protein-associated factors in fission yeast that suppress defects in the anaphase-promoting complex.
Mitsuzawa H et al. J Biol Chem 2001 May 18;276(20):17117-24
PMID:11968006 - Human papillomavirus-16 E7 protein inhibits the DNA interaction of the TATA binding transcription factor.
Maldonado E et al. J Cell Biochem 2002;85(4):663-9
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
PMID:28060464 - RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe.
Montes M et al. FEBS J 2017 Feb;284(4):615-633
PMID:18362178 - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.
Nakazawa N et al. J Cell Biol 2008 Mar 24;180(6):1115-31
PMID:26730850 - Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.
Eckert D et al. PLoS Genet 2016 Jan;12(1):e1005768
PMID:15182371 - Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.
Tamayo E et al. Eur J Biochem 2004 Jun;271(12):2561-72
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27738016 - RNA interference is essential for cellular quiescence.
Roche B et al. Science 2016 Nov 11;354(6313)
PMID:30076928 - Point mutation A394E in the central intrinsic disordered region of Rna14 leads to chromosomal instability in fission yeast.
Sonkar A et al. Int J Biol Macromol 2018 Nov;119:785-791
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:33771877 - RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.
Rivosecchi J et al. Life Sci Alliance 2021 Jun;4(6)
PMID:26257282 - Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.
Iwasaki O et al. Mol Cell 2015 Sep 03;59(5):755-67
PMID:15616156 - Tfg3, a subunit of the general transcription factor TFIIF in Schizosaccharomyces pombe, functions under stress conditions.
Kimura M et al. Nucleic Acids Res 2004;32(22):6706-15
PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.
Li Y et al. Science 1994 Feb 11;263(5148):805-7
PMID:24081329 - Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.
Grenier St-Sauveur V et al. Mol Cell Biol 2013 Dec;33(23):4718-31
PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.
Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90
PMID:11972332 - Identification of histone H4-like TAF in Schizosaccharomyces pombe as a protein that interacts with WD repeat-containing TAF.
Mitsuzawa H et al. Nucleic Acids Res 2002 May 01;30(9):1952-8
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:12682361 - The fission yeast TFIIB-related factor limits RNA polymerase III to a TATA-dependent pathway of TBP recruitment.
Huang Y et al. Nucleic Acids Res 2003 Apr 15;31(8):2108-16
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:20018856 - Involvement of the spliceosomal U4 small nuclear RNA in heterochromatic gene silencing at fission yeast centromeres.
Chinen M et al. J Biol Chem 2010 Feb 19;285(8):5630-8