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protein coding gene - vma16 (SPAC2C4.13) - V-type ATPase V0 subunit c''

Gene summary

Standard name
vma16
Systematic ID
SPAC2C4.13
Product
V-type ATPase V0 subunit c''
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14046
ORFeome ID
06/06F05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 4281448..4284515 forward strand

Annotation

GO biological process

GO:1902600 - proton transmembrane transport

References:

GO:0007035 - vacuolar acidification

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0000329 - fungal-type vacuole membrane

References:

GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain

References:

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0046961 - proton-transporting ATPase activity, rotational mechanism

References:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00137ATP-synt_CATPase_proteolipid_c-like_domPfam
cd18177ATP-synt_Vo_c_ATP6F_rpt1CDD
cd18178ATP-synt_Vo_c_ATP6F_rpt2CDD
PR00122VACATPASEATPase_proteolipid_csuPRINTS
G3DSA:1.20.120.610:FF:000002CATH-FunFam
G3DSA:1.20.120.610F/V-ATP_Csub_sfCATH-Gene3D
SSF81333F/V-ATP_Csub_sfSUPERFAMILY
PTHR10263PANTHER
Transmembrane alpha helixDeepTMHMM
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:16291725 - btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.
Gachet Y et al. J Cell Sci 2005 Dec 01;118(Pt 23):5525-36
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference