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protein coding gene - cao1 (SPAC2E1P3.04) - copper amine oxidase Cao1

Gene summary

Standard name
cao1
Systematic ID
SPAC2E1P3.04
Product
copper amine oxidase Cao1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
spao1
UniProt ID
Q9P7F2
ORFeome ID
37/37E06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 2931772..2935115 forward strand

Annotation

GO biological process

GO:0009310 - amine catabolic process

References:

GO:1990748 - cellular detoxification

References:

GO:0006878 - intracellular copper ion homeostasis

References:

GO cellular component

GO:0042764 - ascospore-type prospore

References:

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

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GO molecular function

GO:0005507 - copper ion binding

References:

GO:0008131 - primary methylamine oxidase activity

References:

GO:0005515 - protein binding

References:

GO:0048038 - quinone binding

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00156 - L-2',4',5'-topaquinone

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:01149 - sumoylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004039 - abolished primary amine oxidase activity

References:

Genotypes:

FYPO:0003073 - decreased primary amine oxidase activity

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Genotypes:

FYPO:0004041 - normal primary amine oxidase activity

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001098 - sensitive to 4-nitroquinoline N-oxide

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF02727Cu_amine_oxidN2Cu_amine_oxidase_N2PFAM
PF02728Cu_amine_oxidN3Cu_amine_oxidase_N3PFAM
PF01179Cu_amine_oxidCu_amine_oxidase_CPFAM
PS01164COPPER_AMINE_OXID_1Cu_Am_ox_TPQ-bdPROSITE_PATTERNS
PS01165COPPER_AMINE_OXID_2Cu_Am_Ox_Cu-bdPROSITE_PATTERNS
G3DSA:2.70.98.20:FF:000001FUNFAM
G3DSA:3.10.450.40:FF:000014FUNFAM
SSF49998Amine oxidase catalytic domainCu_amine_oxidase_C_sfSUPERFAMILY
SSF54416Amine oxidase N-terminal regionCu_amine_oxidase_N-regSUPERFAMILY
G3DSA:2.70.98.20Copper amine oxidase, catalytic domainCu_amine_oxidase_C_sfGENE3D
G3DSA:3.10.450.40GENE3D
PTHR10638COPPER AMINE OXIDASECu_amine_oxidasePANTHER
NF008559PRK11504.1NCBIFAM

Orthologs

References / Literature

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:28572514 - Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination.
Plante S et al. J Biol Chem 2017 Jul 14;292(28):11896-11914
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.
Larochelle M et al. J Cell Sci 2019 May 31;132(11)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24569997 - Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.
Plante S et al. J Biol Chem 2014 Apr 04;289(14):10168-81
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16946276 - Mechanisms of copper loading on the Schizosaccharomyces pombe copper amine oxidase 1 expressed in Saccharomyces cerevisiae.
Laliberté J et al. Microbiology (Reading) 2006 Sep;152(Pt 9):2819-2830
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.
Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72
PMID:18723604 - Copper distributed by Atx1 is available to copper amine oxidase 1 in Schizosaccharomyces pombe.
Peter C et al. Eukaryot Cell 2008 Oct;7(10):1781-94
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827