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protein coding gene - cwg2 (SPAC2E1P5.04c) - geranylgeranyltransferase I beta subunit Cwg2

Gene summary

Standard name
cwg2
Systematic ID
SPAC2E1P5.04c
Product
geranylgeranyltransferase I beta subunit Cwg2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
orb7
UniProt ID
P32434
ORFeome ID
16/16D04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3327940..3329165 reverse strand

Annotation

Complementation

PBO:0017708 - does not functionally complement S. cerevisiae BET2

References:

PBO:0017705 - functionally complemented by S. cerevisiae CDC43

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PBO:0017707 - functionally complements S. cerevisiae CDC43

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PBO:0123296 - is not functionally complemented by S. cerevisiae BET2

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GO biological process

GO:0061951 - establishment of protein localization to plasma membrane

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GO:0072659 - protein localization to plasma membrane

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GO cellular component

GO:0005953 - CAAX-protein geranylgeranyltransferase complex

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0004662 - CAAX-protein geranylgeranyltransferase activity

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GO:0005515 - protein binding

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GO:0004661 - protein geranylgeranyltransferase activity

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GO:0008270 - zinc ion binding

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000164 - abnormal cell separation after cytokinesis

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Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

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Genotypes:

FYPO:0002159 - decreased 1,3-beta-D-glucan synthase activity

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Genotypes:

FYPO:0004641 - decreased CAAX-protein geranylgeranyltransferase activity

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Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

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Genotypes:

FYPO:0001081 - decreased cell wall alpha-glucan level

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Genotypes:

FYPO:0001082 - decreased cell wall beta-glucan level

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Genotypes:

FYPO:0001088 - decreased glucosyltransferase activity

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Genotypes:

FYPO:0002430 - inviable after spore germination, multiple cell divisions

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Genotypes:

FYPO:0002187 - inviable normal volume spheroid vegetative cell

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Genotypes:

FYPO:0004104 - inviable spherical vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001397 - monopolar actin cortical patch localization to old end

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Genotypes:

FYPO:0001086 - normal glucosyltransferase activity

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Genotypes:

FYPO:0004642 - normal protein farnesyltransferase activity

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Genotypes:

FYPO:0004643 - normal Rab geranylgeranyltransferase activity

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Genotypes:

FYPO:0001315 - normal vegetative cell morphology

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0001120 - pear-shaped vegetative cell

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Genotypes:

FYPO:0000646 - swollen vegetative cell

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Genotypes:

FYPO:0000647 - vegetative cell lysis

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Genotypes:

FYPO:0004103 - viable spherical vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00432PrenyltransPrenyltransPFAM
cd02895GGTase-IGGTase_I_betaCDD
G3DSA:1.50.10.20:FF:000066FUNFAM
SSF48239Terpenoid cyclases/Protein prenyltransferasesTerpenoid_cyclase/PrenylTrfaseSUPERFAMILY
G3DSA:1.50.10.20GENE3D
PTHR11774GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNITPGGT1B-likePANTHER

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:9781874 - Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe.
Arellano M et al. Mol Microbiol 1998 Sep;29(6):1357-67
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:8887550 - Rho 1 GTPase activates the (1-3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis.
Arellano M et al. EMBO J 1996 Sep 02;15(17):4584-91
PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.
Verde F et al. J Cell Biol 1995 Dec;131(6 Pt 1):1529-38
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:8262067 - The Schizosaccharomyces pombe cwg2+ gene codes for the beta subunit of a geranylgeranyltransferase type I required for beta-glucan synthesis.
Díaz M et al. EMBO J 1993 Dec 15;12(13):5245-54
PMID:1828464 - Isolation and characterization of Schizosaccharomyces pombe mutants defective in cell wall (1-3)beta-D-glucan.
Ribas JC et al. J Bacteriol 1991 Jun;173(11):3456-62
PMID:25651781 - Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.
Doi A et al. Genes Cells 2015 Apr;20(4):310-23