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protein coding gene - imt1 (SPAC2F3.01) - inositol phosphorylceramide mannosyltransferase activity Imt1

Gene summary

Standard name
imt1
Systematic ID
SPAC2F3.01
Product
inositol phosphorylceramide mannosyltransferase activity Imt1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC323.09
UniProt ID
O14084
ORFeome ID
13/13F01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3922354..3923496 forward strand

Annotation

GO biological process

GO:0051999 - mannosyl-inositol phosphorylceramide biosynthetic process

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GO cellular component

GO:0033106 - cis-Golgi network membrane

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GO:0005794 - Golgi apparatus

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GO:0005802 - trans-Golgi network

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GO:0032588 - trans-Golgi network membrane

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GO molecular function

GO:0103064 - inositol phosphorylceramide mannosyltransferase activity

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Modification

MOD:00006 - N-glycosylated residue

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Multi-locus phenotype

FYPO:0000034 - abnormal endocytosis during vegetative growth

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Genotypes:

FYPO:0000135 - abnormal plasma membrane sterol distribution

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Genotypes:

FYPO:0005508 - abnormal plasma membrane to vacuole transport

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Genotypes:

FYPO:0004483 - abnormal vacuole fusion during cellular hypotonic response

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Genotypes:

FYPO:0005290 - decreased protein localization to plasma membrane at cell division site during vegetative growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0008262 - mannosylinositol phosphorylceramide absent from cell

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Genotypes:

FYPO:0000076 - resistance to nystatin

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Genotypes:

FYPO:0002642 - sensitive to amphotericin B

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Genotypes:

FYPO:0000098 - sensitive to calcium

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Genotypes:

FYPO:0002788 - small vacuoles during vegetative growth

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Genotypes:

FYPO:0000024 - stubby vegetative cell

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Genotypes:

Protein sequence feature

SO:0001809 - signal_anchor

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0005290 - decreased protein localization to plasma membrane at cell division site during vegetative growth

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000073 - resistance to caffeine

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0001097 - sensitive to amitrole

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Genotypes:

FYPO:0009067 - sensitive to amorolfine

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Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Warnings

PBO:0091512 - although the specificity is different Imt1/A4GALT are in equivalent pathway postitions

Protein features

IDNameInterPro nameDB name
PF04488Gly_transf_sugGlycoTrfase_DXDPfam
G3DSA:3.90.550.20:FF:000005CATH-FunFam
G3DSA:3.90.550.20CATH-Gene3D
SSF53448Nucleotide-diphossugar_transSUPERFAMILY
PTHR32385Glycosyltransferase_domainPANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:20388730 - Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe.
Nakase M et al. J Cell Sci 2010 May 01;123(Pt 9):1578-87
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37792890 - Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast.
Willet AH et al. PLoS Genet 2023 Oct;19(10):e1010987