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protein coding gene - hem1 (SPAC2F3.09) - 5-aminolevulinate synthase Hem1

Gene summary

Standard name
hem1
Systematic ID
SPAC2F3.09
Product
5-aminolevulinate synthase Hem1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14092
ORFeome ID
35/35B01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3939665..3942086 forward strand

Annotation

Disease association

MONDO:0001676 - erythropoietic protoporphyria

References:

MONDO:0008786 - pyridoxine-responsive sideroblastic anemia

References:

MONDO:0010420 - X-linked erythropoietic protoporphyria

References:

MONDO:0020721 - X-linked sideroblastic anemia 1

References:

GO biological process

GO:0006783 - heme biosynthetic process

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

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GO molecular function

GO:0003870 - 5-aminolevulinate synthase activity

References:

GO:0030170 - pyridoxal phosphate binding

References:

Modification

MOD:00128 - N6-pyridoxal phosphate-L-lysine

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

Multi-locus phenotype

FYPO:0007397 - abolished heme import

References:

Genotypes:

FYPO:0007396 - decreased heme import

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00155Aminotran_1_2Aminotransferase_I/II_largePfam
cd06454KBL_likeCDD
PS00599AA_TRANSFER_CLASS_2Aminotrans_II_pyridoxalP_BSPROSITE patterns
G3DSA:3.40.640.10:FF:000006CATH-FunFam
G3DSA:3.40.640.10PyrdxlP-dep_Trfase_majorCATH-Gene3D
G3DSA:3.90.1150.10PyrdxlP-dep_Trfase_smallCATH-Gene3D
SSF53383PyrdxlP-dep_TrfaseSUPERFAMILY
PTHR13693AON_synthase_class-IIPANTHER
TIGR018215aminolev_synth4pyrrol_synth_NH2levulA_synthNCBIFAM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:21653323 - ALAS2 acts as a modifier gene in patients with congenital erythropoietic porphyria.
To-Figueras J et al. Blood 2011 Aug 11;118(6):1443-51
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:9542324 - The molecular biology and pyridoxine responsiveness of X-linked sideroblastic anaemia.
May A et al. Haematologica 1998 Jan;83(1):56-70
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000002 - Comments
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25733668 - Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe.
Mourer T et al. J Biol Chem 2015 Apr 17;290(16):10176-90
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:15797383 - SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Hughes AL et al. Cell 2005 Mar 25;120(6):831-42
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83
PMID:28193844 - Heme Assimilation in Schizosaccharomyces pombe Requires Cell-surface-anchored Protein Shu1 and Vacuolar Transporter Abc3.
Mourer T et al. J Biol Chem 2017 Mar 24;292(12):4898-4912
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:19139265 - The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
Roberts-Galbraith RH et al. J Cell Biol 2009 Jan 12;184(1):113-27
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29549126 - The major facilitator transporter Str3 is required for low-affinity heme acquisition in Schizosaccharomyces pombe .
Normant V et al. J Biol Chem 2018 Apr 27;293(17):6349-6362
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.
Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671