PomBase home

protein coding gene - pom1 (SPAC2F7.03c) - DYRK family cell polarity protein kinase Pom1

Gene summary

Standard name
pom1
Systematic ID
SPAC2F7.03c
Product
DYRK family cell polarity protein kinase Pom1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q09690
ORFeome ID
30/30C08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 534120..537873 reverse strand

Annotation

Comment

PBO:0000437 - forms a polar gradient

References:

GO biological process

GO:0030950 - establishment or maintenance of actin cytoskeleton polarity

References:

GO:0061245 - establishment or maintenance of bipolar cell polarity

References:

GO:0031569 - mitotic G2 cell size control checkpoint signaling

References:

GO:1903138 - negative regulation of cell integrity MAPK cascade

References:

GO:0010972 - negative regulation of G2/M transition of mitotic cell cycle

References:

GO:1903500 - negative regulation of mitotic actomyosin contractile ring assembly

References:

GO:1903067 - negative regulation of protein localization to cell tip

References:

GO:1903077 - negative regulation of protein localization to plasma membrane

References:

GO:0051518 - positive regulation of bipolar cell growth

References:

GO:1903617 - positive regulation of mitotic cytokinesis, division site positioning

References:

GO:0032956 - regulation of actin cytoskeleton organization

References:

GO:0032878 - regulation of establishment or maintenance of cell polarity

References:

GO cellular component

GO:0051285 - cell cortex of cell tip

References:

GO:0032153 - cell division site

References:

GO:0051286 - cell tip

References:

GO:0097575 - lateral cell cortex

References:

GO:0120105 - mitotic actomyosin contractile ring, intermediate layer

References:

GO:0005886 - plasma membrane

References:

GO:0030427 - site of polarized growth

References:

GO molecular function

GO:1901981 - phosphatidylinositol phosphate binding

References:

GO:0005515 - protein binding

References:

GO:0004674 - protein serine/threonine kinase activity

References:

GO:0004713 - protein tyrosine kinase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01149 - sumoylated lysine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0000190 - abnormal actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0002455 - abnormal septum during vegetative growth

References:

Genotypes:

FYPO:0001118 - abnormal vegetative cell morphology

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0001880 - abolished protein localization to cell division site

References:

Genotypes:

FYPO:0002126 - abolished protein localization to plasma membrane during vegetative growth

References:

Genotypes:

FYPO:0002128 - abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth

References:

Genotypes:

FYPO:0001394 - activation of monopolar cell growth at either end

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0002699 - decreased protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0006637 - decreased protein localization to cell cortex of cell tip, with protein distributed in cortex

References:

Genotypes:

FYPO:0002556 - decreased protein localization to medial cortex, with protein distributed in cell cortex near non-growing end, during vegetative growth

References:

Genotypes:

FYPO:0006638 - decreased protein localization to medial cortex, with protein distributed in cell cortex, during vegetative growth

References:

Genotypes:

FYPO:0006326 - decreased protein localization to medial cortical node

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000155 - increased flocculation

References:

Genotypes:

FYPO:0001740 - increased gross chromosomal rearrangement

References:

Genotypes:

FYPO:0003307 - increased mitotic index

References:

Genotypes:

FYPO:0009061 - increased protein localization to cell cortex during mitotic interphase

References:

Genotypes:

FYPO:0008075 - increased protein localization to cell cortex of cell tip during vegetative growth

References:

Genotypes:

FYPO:0001038 - increased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001406 - increased septum thickness

References:

Genotypes:

FYPO:0001991 - inviable after spore germination, without cell division

References:

Genotypes:

FYPO:0002452 - inviable septated vegetative cell with abnormal cell morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0005880 - long interphase microtubules curved around cell end

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0000118 - multiseptate vegetative cell

References:

Genotypes:

FYPO:0002141 - normal cell population growth at low temperature

References:

Genotypes:

FYPO:0005970 - normal growth on magnesium chloride

References:

Genotypes:

FYPO:0000405 - normal mitotic G2/M phase transition

References:

Genotypes:

FYPO:0003736 - normal mitotic index

References:

Genotypes:

FYPO:0002558 - normal protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002253 - normal septum location

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001124 - normal vegetative cell size

References:

Genotypes:

FYPO:0002516 - premature mitotic G2/M phase transition

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0007393 - septum mislocalized to cell tip

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0000945 - swollen spheroid vegetative cell

References:

Genotypes:

FYPO:0007379 - T-shaped vegetative cell

References:

Genotypes:

FYPO:0000013 - T-shaped vegetative cell with normal cell length

References:

Genotypes:

FYPO:0003389 - viable elongated vegetative cell with swollen medial region

References:

Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0004103 - viable spherical vegetative cell

References:

Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

References:

Genotypes:

Protein features

PBO:0111778 - DYRK subfamily

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000190 - abnormal actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0002029 - abnormal cell division, large and small daughter cells

References:

Genotypes:

FYPO:0002736 - abnormal mitotic cell cycle phase

References:

Genotypes:

FYPO:0006547 - abnormal plasma membrane phosphatidylserine distribution resulting in decreased concentration at cell tip

References:

Genotypes:

FYPO:0001584 - abnormal protein localization to cell tip during vegetative growth

References:

Genotypes:

FYPO:0001129 - abnormal protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0001018 - abolished NETO

References:

Genotypes:

FYPO:0001384 - abolished protein kinase activity

References:

Genotypes:

FYPO:0001585 - abolished protein localization to cell tip during vegetative growth

References:

Genotypes:

FYPO:0002033 - abolished protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0001394 - activation of monopolar cell growth at either end

References:

Genotypes:

FYPO:0003535 - decreased bipolar index

References:

Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

References:

Genotypes:

FYPO:0009075 - decreased cell population growth on fructose carbon source

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

References:

Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0003150 - decreased NETO

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0000929 - decreased protein localization to cell cortex during vegetative growth

References:

Genotypes:

FYPO:0006637 - decreased protein localization to cell cortex of cell tip, with protein distributed in cortex

References:

Genotypes:

FYPO:0001586 - decreased protein localization to cell tip during vegetative growth

References:

Genotypes:

FYPO:0003208 - decreased protein localization to cell tip, with protein distributed in plasma membrane or cortex

References:

Genotypes:

FYPO:0002557 - decreased protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0002556 - decreased protein localization to medial cortex, with protein distributed in cell cortex near non-growing end, during vegetative growth

References:

Genotypes:

FYPO:0006638 - decreased protein localization to medial cortex, with protein distributed in cell cortex, during vegetative growth

References:

Genotypes:

FYPO:0003771 - decreased protein localization to plasma membrane of cell tip during vegetative growth

References:

Genotypes:

FYPO:0002679 - decreased protein phosphorylation

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002830 - delayed onset of protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0006772 - dispersed actin cortical patch localization during mating

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009028 - increased cell population growth on proline nitrogen source

References:

Genotypes:

FYPO:0001740 - increased gross chromosomal rearrangement

References:

Genotypes:

FYPO:0003532 - increased monopolar index

References:

Genotypes:

FYPO:0006610 - increased protein dwell time during intermittent localization to Cdr2 medial cortical node complex

References:

Genotypes:

FYPO:0009061 - increased protein localization to cell cortex during mitotic interphase

References:

Genotypes:

FYPO:0007156 - increased protein localization to medial cortical node

References:

Genotypes:

FYPO:0002680 - increased protein phosphorylation

References:

Genotypes:

FYPO:0001038 - increased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0006608 - intermittent protein localization to Cdr2 medial cortical node complex decoupled from cell size

References:

Genotypes:

FYPO:0003712 - lateral cortical nodes present in increased numbers

References:

Genotypes:

FYPO:0001369 - mislocalized actomyosin contractile ring

References:

Genotypes:

FYPO:0001417 - mislocalized eMTOC

References:

Genotypes:

FYPO:0000339 - mislocalized septum during vegetative growth

References:

Genotypes:

FYPO:0001391 - mislocalized septum, near new end

References:

Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

References:

Genotypes:

FYPO:0001398 - monopolar actin cortical patch localization to either end

References:

Genotypes:

FYPO:0003717 - normal actin cytoskeleton morphology during vegetative growth

References:

Genotypes:

FYPO:0001368 - normal actomyosin contractile ring assembly

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0001400 - normal interphase microtubules

References:

Genotypes:

FYPO:0000760 - normal mating

References:

Genotypes:

FYPO:0000478 - normal meiosis

References:

Genotypes:

FYPO:0005207 - normal mitotic cell cycle regulation upon nitrogen source shift

References:

Genotypes:

FYPO:0003736 - normal mitotic index

References:

Genotypes:

FYPO:0001399 - normal mitotic spindle

References:

Genotypes:

FYPO:0001396 - normal NETO

References:

Genotypes:

FYPO:0001389 - normal nucleus positioning

References:

Genotypes:

FYPO:0003075 - normal protein kinase activity

References:

Genotypes:

FYPO:0000644 - normal protein localization during vegetative growth

References:

Genotypes:

FYPO:0002559 - normal protein localization to actomyosin contractile ring

References:

Genotypes:

FYPO:0001402 - normal protein localization to cell cortex during vegetative growth

References:

Genotypes:

FYPO:0007451 - normal protein localization to cell cortex of cell tip during vegetative growth

References:

Genotypes:

FYPO:0001587 - normal protein localization to cell tip during vegetative growth

References:

Genotypes:

FYPO:0002558 - normal protein localization to medial cortex during vegetative growth

References:

Genotypes:

FYPO:0002674 - normal protein localization to plasma membrane

References:

Genotypes:

FYPO:0003414 - normal protein localization to septum

References:

Genotypes:

FYPO:0008003 - normal protein localization to site of mechanical stress

References:

Genotypes:

FYPO:0004422 - normal protein phosphorylation

References:

Genotypes:

FYPO:0001266 - normal protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0002253 - normal septum location

References:

Genotypes:

FYPO:0000590 - normal sporulation

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001125 - normal vegetative cell shape

References:

Genotypes:

FYPO:0002516 - premature mitotic G2/M phase transition

References:

Genotypes:

FYPO:0003527 - protein mislocalized to cell tip

References:

Genotypes:

FYPO:0005466 - protein mislocalized to non-growing cell tip

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0003595 - S-shaped cell

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0007921 - sensitive to benzamidine

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001188 - sensitive to Calcofluor White

References:

Genotypes:

FYPO:0003840 - sensitive to carbendazim

References:

Genotypes:

FYPO:0001245 - sensitive to cobalt

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0002167 - sensitive to ethyl methanesulfonate

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0000107 - sensitive to latrunculin A

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000112 - sensitive to sorbitol

References:

Genotypes:

FYPO:0002328 - sensitive to terbinafine

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0009064 - sensitive to X-rays and rapamycin during vegetative growth.

References:

Genotypes:

FYPO:0007393 - septum mislocalized to cell tip

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0007379 - T-shaped vegetative cell

References:

Genotypes:

FYPO:0000013 - T-shaped vegetative cell with normal cell length

References:

Genotypes:

FYPO:0002460 - viable branched, curved, elongated vegetative cell

References:

Genotypes:

FYPO:0002112 - viable curved vegetative cell

References:

Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0009798 - faster evolving duplicate

Protein features

IDNameInterPro nameDB name
PF00069PkinaseProt_kinase_domPFAM
cd14210PKc_DYRKCDD
PS00108PROTEIN_KINASE_STSer/Thr_kinase_ASPROSITE_PATTERNS
PS00107PROTEIN_KINASE_ATPProtein_kinase_ATP_BSPROSITE_PATTERNS
PS50011PROTEIN_KINASE_DOMProt_kinase_domPROSITE_PROFILES
SM00220serkin_6Prot_kinase_domSMART
G3DSA:1.10.510.10:FF:000380FUNFAM
SSF56112Protein kinase-like (PK-like)Kinase-like_dom_sfSUPERFAMILY
G3DSA:3.30.200.20Phosphorylase Kinase; domain 1GENE3D
G3DSA:3.30.10.30DYRKDYRKGENE3D
G3DSA:1.10.510.10Transferase(Phosphotransferase) domain 1GENE3D
PTHR24058DUAL SPECIFICITY PROTEIN KINASESer_Thr_dual-spec_kinasePANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMOBIDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:22624651 - A systematic screen reveals new elements acting at the G2/M cell cycle control.
Navarro FJ et al. Genome Biol 2012 May 24;13(5):R36
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:14663827 - Role of Tea1p, Tea3p and Pom1p in the determination of cell ends in Schizosaccharomyces pombe.
Niccoli T et al. Yeast 2003 Dec;20(16):1349-58
PMID:20164182 - Rga4 modulates the activity of the fission yeast cell integrity MAPK pathway by acting as a Rho2 GTPase-activating protein.
Soto T et al. J Biol Chem 2010 Apr 09;285(15):11516-25
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:26150232 - Pom1 gradient buffering through intermolecular auto-phosphorylation.
Hersch M et al. Mol Syst Biol 2015 Jul 06;11(7):818
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12
PMID:19474789 - A spatial gradient coordinates cell size and mitotic entry in fission yeast.
Moseley JB et al. Nature 2009 Jun 11;459(7248):857-60
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.
Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:24982431 - Pom1 regulates the assembly of Cdr2-Mid1 cortical nodes for robust spatial control of cytokinesis.
Rincon SA et al. J Cell Biol 2014 Jul 07;206(1):61-77
PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.
Kelkar M et al. Nat Commun 2015 Oct 07;6:8445
PMID:23349808 - Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.
Jourdain I et al. PLoS One 2013;8(1):e54142
PMID:29514920 - Cell size-dependent regulation of Wee1 localization by Cdr2 cortical nodes.
Allard CAH et al. J Cell Biol 2018 May 07;217(5):1589-1599
PMID:26566110 - Sizing up to divide: mitotic cell-size control in fission yeast.
Wood E et al. Annu Rev Cell Dev Biol 2015;31:11-29
PMID:32101481 - DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.
Bhattacharjee R et al. Mol Biol Cell 2020 Apr 15;31(9):917-929
PMID:36633091 - Microtubule-mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast.
Chacko LA et al. J Cell Sci 2023 Jan 01;136(1)
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39666777 - Fission yeast essential nuclear pore protein Nup211 regulates the expression of genes involved in cytokinesis.
Kamel D et al. PLoS One 2024;19(12):e0312095
PMID:34666001 - Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast.
Neeli-Venkata R et al. Dev Cell 2021 Oct 25;56(20):2856-2870.e7
PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.
Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:31553675 - The phosphatase inhibitor Sds23 regulates cell division symmetry in fission yeast.
Schutt KL et al. Mol Biol Cell 2019 Nov 01;30(23):2880-2889
PMID:9852154 - Role of polo kinase and Mid1p in determining the site of cell division in fission yeast.
Bähler J et al. J Cell Biol 1998 Dec 14;143(6):1603-16
PMID:20434336 - The cortical ER network limits the permissive zone for actomyosin ring assembly.
Zhang D et al. Curr Biol 2010 Jun 08;20(11):1029-34
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:39156640 - Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic.
Ramos M et al. iScience 2024 Aug 16;27(8):110477
PMID:22174761 - Roles of the DYRK kinase Pom2 in cytokinesis, mitochondrial morphology, and sporulation in fission yeast.
Wu P et al. PLoS One 2011;6(12):e28000
PMID:28914606 - Nanoscale architecture of the Schizosaccharomyces pombe contractile ring.
McDonald NA et al. Elife 2017 Sep 15;6
PMID:37237082 - Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere.
Mongia P et al. Commun Biol 2023 May 26;6(1):551
PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.
Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601
PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.
Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.
Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813
PMID:29249658 - Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.
Lee ME et al. Curr Biol 2018 Jan 08;28(1):84-92.e4
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28162898 - SIN-Dependent Dissociation of the SAD Kinase Cdr2 from the Cell Cortex Resets the Division Plane.
Rincon SA et al. Curr Biol 2017 Feb 20;27(4):534-542
PMID:20870879 - Reorganization of the growth pattern of Schizosaccharomyces pombe in invasive filament formation.
Dodgson J et al. Eukaryot Cell 2010 Nov;9(11):1788-97
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16988828 - Spatial regulation of cytokinesis by the Kin1 and Pom1 kinases in fission yeast.
La Carbona S et al. Curr Genet 2006 Dec;50(6):377-91
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:12206652 - Mac1, a fission yeast transmembrane protein localizing to the poles and septum, is required for correct cell separation at high temperatures.
Grandin N et al. Biol Cell 2002 Jun;94(3):127-37
PMID:12007420 - Tea3p is a cell end marker activating polarized growth in Schizosaccharomyces pombe.
Arellano M et al. Curr Biol 2002 Apr 30;12(9):751-6
PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.
Nie M et al. Sci Rep 2015 Sep 25;5:14389
PMID:27852900 - Gradients of phosphatidylserine contribute to plasma membrane charge localization and cell polarity in fission yeast.
Haupt A et al. Mol Biol Cell 2017 Jan 01;28(1):210-220
PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.
Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71
PMID:28784611 - Phosphoinositide-mediated ring anchoring resists perpendicular forces to promote medial cytokinesis.
Snider CE et al. J Cell Biol 2017 Oct 02;216(10):3041-3050
PMID:32059768 - Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.
Sun XM et al. Curr Biol 2020 Apr 06;30(7):1217-1230.e7
PMID:34958661 - Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.
Opalko HE et al. J Cell Biol 2022 Feb 07;221(2)
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:9679144 - Regulation of cell polarity by microtubules in fission yeast.
Sawin KE et al. J Cell Biol 1998 Jul 27;142(2):457-71
PMID:29930085 - Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1-Tea4-Pom1 axis.
Tay YD et al. J Cell Sci 2018 Jul 19;131(14)
PMID:12789340 - Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips.
Snaith HA et al. Nature 2003 Jun 05;423(6940):647-51
PMID:38228139 - Live-cell imaging defines a threshold in CDK activity at the G2/M transition.
Sugiyama H et al. Dev Cell 2024 Jan 08;
PMID:39110593 - VAP-mediated membrane-tethering mechanisms implicate ER-PM contact function in pH homeostasis.
Hoh KL et al. Cell Rep 2024 Aug 05;43(8):114592
PMID:21703453 - A phosphorylation cycle shapes gradients of the DYRK family kinase Pom1 at the plasma membrane.
Hachet O et al. Cell 2011 Jun 24;145(7):1116-28
PMID:18495844 - Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast.
Daga RR et al. J Cell Sci 2008 Jun 15;121(Pt 12):1973-80
PMID:12034771 - Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton.
Behrens R et al. J Cell Biol 2002 May 27;157(5):783-93
PMID:11950884 - Different mechanisms of cell polarisation in vegetative and shmooing growth in fission yeast.
Niccoli T et al. J Cell Sci 2002 Apr 15;115(Pt 8):1651-62
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:30853434 - NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.
Willet AH et al. Curr Biol 2019 Mar 18;29(6):1055-1063.e2
PMID:24554432 - The Tea4-PP1 landmark promotes local growth by dual Cdc42 GEF recruitment and GAP exclusion.
Kokkoris K et al. J Cell Sci 2014 May 01;127(Pt 9):2005-16
PMID:24047646 - Pom1 and cell size homeostasis in fission yeast.
Wood E et al. Cell Cycle 2013 Oct 01;12(19):3228-36
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:36749320 - Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.
Bhattacharjee R et al. Elife 2023 Feb 07;12
PMID:37746062 - Polarity kinases that phosphorylate F-BAR protein Cdc15 have unique localization patterns during cytokinesis and contributions to preventing tip septation in Schizosaccharomyces pombe .
Igarashi MG et al. MicroPubl Biol 2023;2023
PMID:18197241 - urg1: a uracil-regulatable promoter system for fission yeast with short induction and repression times.
Watt S et al. PLoS One 2008 Jan 16;3(1):e1428
PMID:24342487 - Spatiotemporal organization of microbial cells by protein concentration gradients.
Kiekebusch D et al. Trends Microbiol 2014 Feb;22(2):65-73
PMID:24508166 - Dueling kinases regulate cell size at division through the SAD kinase Cdr2.
Deng L et al. Curr Biol 2014 Feb 17;24(4):428-33
PMID:25210736 - Dynamics of cell shape inheritance in fission yeast.
Abenza JF et al. PLoS One 2014;9(9):e106959
PMID:15936270 - Wsh3/Tea4 is a novel cell-end factor essential for bipolar distribution of Tea1 and protects cell polarity under environmental stress in S. pombe.
Tatebe H et al. Curr Biol 2005 Jun 07;15(11):1006-15
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:11230130 - Fission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division.
Bähler J et al. EMBO J 2001 Mar 01;20(5):1064-73
PMID:9573052 - Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.
Bähler J et al. Genes Dev 1998 May 01;12(9):1356-70
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:20974849 - Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.
Núñez A et al. J Biol Chem 2010 Dec 31;285(53):41366-73
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:19474792 - Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle.
Martin SG et al. Nature 2009 Jun 11;459(7248):852-6
PMID:22684255 - The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.
Grallert A et al. Nat Cell Biol 2012 Jun 10;14(7):738-45
PMID:27736299 - A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.
Moris N et al. Cell Cycle 2016 Nov 16;15(22):3121-3130
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:18328707 - Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast.
Tatebe H et al. Curr Biol 2008 Mar 11;18(5):322-30
PMID:24316795 - Distinct levels in Pom1 gradients limit Cdr2 activity and localization to time and position division.
Bhatia P et al. Cell Cycle 2014;13(4):538-52
PMID:22427686 - Characterization of Mid1 domains for targeting and scaffolding in fission yeast cytokinesis.
Lee IJ et al. J Cell Sci 2012 Jun 15;125(Pt 12):2973-85