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protein coding gene - akr1 (SPAC2F7.10) - palmitoyltransferase Akr1

Gene summary

Standard name
akr1
Systematic ID
SPAC2F7.10
Product
palmitoyltransferase Akr1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q09701
ORFeome ID
26/26H01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 550768..553595 forward strand

Annotation

GO biological process

GO:0006612 - protein targeting to membrane

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GO cellular component

GO:0031901 - early endosome membrane

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GO:0005783 - endoplasmic reticulum

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GO:0000329 - fungal-type vacuole membrane

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GO:0005794 - Golgi apparatus

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GO molecular function

GO:0019706 - protein-cysteine S-palmitoyltransferase activity

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Modification

MOD:00046 - O-phospho-L-serine

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Protein features

PBO:0111781 - ankyrin repeat protein

PBO:0111782 - zf-DHHC type

PBO:0111743 - zinc finger protein

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000023 - protein level constant

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002890 - abnormal horsetail nucleus morphology

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Genotypes:

FYPO:0000510 - abnormal nuclear fusion during mating

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Genotypes:

FYPO:0002711 - abnormal nuclear separation after meiosis

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Genotypes:

FYPO:0000443 - abnormal protein localization during vegetative growth

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Genotypes:

FYPO:0000348 - abnormal spore morphology

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0002505 - decreased protein palmitoylation

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Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0004796 - normal azygotic meiosis

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Genotypes:

FYPO:0002501 - normal protein palmitoylation during meiosis

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Genotypes:

FYPO:0002502 - normal protein palmitoylation during vegetative growth

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Genotypes:

FYPO:0001450 - resistance to cold

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003182 - sister chromatid nondisjunction at meiosis II

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00023AnkAnkyrin_rptPfam
PF01529DHHCPalmitoyltrfase_DHHCPfam
PF12796Ank_2Ankyrin_rptPfam
PS50088ANK_REPEATAnkyrin_rptPROSITE profiles
PS50216DHHCPROSITE profiles
PS50297ANK_REP_REGIONPROSITE profiles
SM00248ANKAnkyrin_rptSMART
G3DSA:1.25.40.20Ankyrin_rpt-contain_sfCATH-Gene3D
SSF48403Ankyrin_rpt-contain_sfSUPERFAMILY
PTHR24161PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:23843742 - Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.
Zhang MM et al. PLoS Biol 2013 Jul;11(7):e1001597
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333
GO_REF:0000044 - Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
PMID:36650056 - Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe .
Pham TV et al. Life Sci Alliance 2023 Apr;6(4)
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.
Malecki M et al. Genome Biol 2016 Nov 25;17(1):240
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053