protein coding gene - smn1 (SPAC2G11.08c) - SMN complex subunit Smn1/Gem1

Gene summary

Standard name

smn1

Systematic ID

SPAC2G11.08c

Product

SMN complex subunit Smn1/Gem1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

yab8

UniProt ID

Q09808

ORFeome ID

05/05B03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 822092..822954 reverse strand

Annotation

Protein features

Orthologs

• SMN1 (HGNC:11117) Homo sapiens
• smn1 (SJAG_03894) Schizosaccharomyces japonicus

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:10749974 - Characterization of the Schizosaccharomyces pombe orthologue of the human survival motor neuron (SMN) protein.

Owen N et al. Hum Mol Genet 2000 Mar 22;9(5):675-84

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:27388936 - Disruption of snRNP biogenesis factors Tgs1 and pICln induces phenotypes that mirror aspects of SMN-Gemins complex perturbation in Drosophila, providing new insights into spinal muscular atrophy.

Borg RM et al. Neurobiol Dis 2016 Oct;94:245-58

PMID:23221635 - Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.

Piazzon N et al. Nucleic Acids Res 2013 Jan;41(2):1255-72

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26092730 - Oligomeric Properties of Survival Motor Neuron·Gemin2 Complexes.

Gupta K et al. J Biol Chem 2015 Aug 14;290(33):20185-99

PMID:31927482 - Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant.

Antoine M et al. iScience 2020 Jan 24;23(1):100809

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:20400941 - Specific splicing defects in S. pombe carrying a degron allele of the Survival of Motor Neuron gene.

Campion Y et al. EMBO J 2010 Jun 02;29(11):1817-29

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10749973 - The Schizosaccharomyces pombe protein Yab8p and a novel factor, Yip1p, share structural and functional similarity with the spinal muscular atrophy-associated proteins SMN and SIP1.

Hannus S et al. Hum Mol Genet 2000 Mar 22;9(5):663-74

PMID:10816558 - The survival motor neuron protein of Schizosacharomyces pombe. Conservation of survival motor neuron interaction domains in divergent organisms.

Paushkin S et al. J Biol Chem 2000 Aug 04;275(31):23841-6

PMID:25274039 - A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.

Bayne EH et al. Genome Biol 2014;15(10):481

PMID:26098872 - Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila.

Borg RM et al. PLoS One 2015;10(6):e0130974

PMID:30759079 - A systematic genetic screen identifies essential factors involved in nuclear size control.

Cantwell H et al. PLoS Genet 2019 Feb;15(2):e1007929

PB_REF:0000003 - Disease Association Curation

PMID:33754639 - Identification and structural analysis of the Schizosaccharomyces pombe SMN complex.

Veepaschit J et al. Nucleic Acids Res 2021 Jul 21;49(13):7207-7223

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:24298023 - Characterization and in vivo functional analysis of the Schizosaccharomyces pombe ICLN gene.

Barbarossa A et al. Mol Cell Biol 2014 Feb;34(4):595-605