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protein coding gene - rqh1 (SPAC2G11.12) - RecQ type DNA helicase Rqh1

Gene summary

Standard name
rqh1
Systematic ID
SPAC2G11.12
Product
RecQ type DNA helicase Rqh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
hus2, rad12, rec9
UniProt ID
Q09811
ORFeome ID
39/39D09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 831937..836094 forward strand

Annotation

Complementation

PBO:0017547 - functionally complemented by E. coli RusA

References:

PBO:0024821 - functionally complemented by human GEN1

References:

Disease association

MONDO:0008876 - Bloom syndrome

References:

MONDO:0010196 - Werner syndrome

References:

GO biological process

GO:0006974 - DNA damage response

References:

GO:0006301 - DNA damage tolerance

References:

GO:0000729 - DNA double-strand break processing

References:

GO:0000724 - double-strand break repair via homologous recombination

References:

GO:0043007 - maintenance of rDNA

References:

GO:0031573 - mitotic intra-S DNA damage checkpoint signaling

References:

GO:1990426 - mitotic recombination-dependent replication fork processing

References:

GO:0000725 - recombinational repair

References:

GO:0031297 - replication fork processing

References:

GO:0071140 - resolution of mitotic recombination intermediates

References:

GO:0070914 - UV-damage excision repair

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0000228 - nuclear chromosome

References:

GO:0043596 - nuclear replication fork

References:

GO:0005730 - nucleolus

References:

GO:0031422 - RecQ family helicase-topoisomerase III complex

References:

GO:0035861 - site of double-strand break

References:

GO molecular function

GO:0043138 - 3'-5' DNA helicase activity

References:

GO:0005524 - ATP binding

References:

GO:0003677 - DNA binding

References:

GO:0009378 - four-way junction helicase activity

References:

GO:0005515 - protein binding

References:

Modification

MOD:00595 - monomannosylated residue

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01149 - sumoylated lysine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0002553 - abnormal double-strand break processing

References:

Genotypes:

FYPO:0005658 - abnormal frequency of meiotic crossover associated with gene conversion

References:

Genotypes:

FYPO:0000481 - abnormal mitotic recombination

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0002702 - circularized chromosome

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0001052 - cut, small cell

References:

Genotypes:

FYPO:0005943 - decreased break-induced loss of heterozygosity via chromosomal translocation

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0006318 - decreased DNA resection during replication fork processing

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0005608 - decreased histone H2B-K119 ubiquitination at double-strand break site during vegetative growth

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0005388 - decreased number of Rad51 foci during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002474 - decreased protein localization to double-strand break site

References:

Genotypes:

FYPO:0003483 - decreased punctate nuclear protein localization during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0003085 - decreased replication fork arrest at mating-type locus

References:

Genotypes:

FYPO:0005939 - decreased replicative lifespan

References:

Genotypes:

FYPO:0005357 - decreased site-specific DNA replication termination at RTS1 barrier

References:

Genotypes:

FYPO:0005786 - decreased spatial extent of double-strand break processing

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0004985 - entangled telomeres during vegetative growth

References:

Genotypes:

FYPO:0005432 - globally decreased mitotic recombination

References:

Genotypes:

FYPO:0005452 - increased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0005944 - increased break-induced loss of heterozygosity via chromosomal truncation

References:

Genotypes:

FYPO:0003584 - increased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0005659 - increased frequency of meiotic crossover associated with gene conversion

References:

Genotypes:

FYPO:0004709 - increased number of Rad52 foci

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0002573 - increased number of Ssb1 foci

References:

Genotypes:

FYPO:0005435 - inviable after spore germination with elongated germ tube and fragmented nucleus

References:

Genotypes:

FYPO:0007140 - inviable after spore germination, multiple cell divisions, swollen, elongated cell

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003587 - loss of gross chromosomal rearrangement during replication fork processing

References:

Genotypes:

FYPO:0005704 - loss of viability following cellular response to hydroxyurea

References:

Genotypes:

FYPO:0005705 - loss of viability following cellular response to UV

References:

Genotypes:

FYPO:0006923 - normal DNA recombination frequency at mitotic DNA replication fork barriers

References:

Genotypes:

FYPO:0005392 - normal DNA recombination frequency during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002887 - normal protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0006570 - normal UV-damage excision repair

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0003107 - progressively shortening telomeres during vegetative growth

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002550 - sensitive to UV

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

References:

Genotypes:

FYPO:0002058 - viable cell population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Protein features

PBO:0111747 - DEAD/DEAH box helicase

PBO:0111799 - RecQ family

PBO:0111800 - Req family helicase

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0000670 - abnormal mitotic sister chromatid separation

References:

Genotypes:

FYPO:0000007 - abnormal S-phase DNA damage checkpoint

References:

Genotypes:

FYPO:0002101 - abolished 3'-5' DNA helicase activity

References:

Genotypes:

FYPO:0004029 - abolished 5' deoxyribonuclease (pyrimidine dimer) activity

References:

Genotypes:

FYPO:0003814 - abolished response to S-phase DNA damage checkpoint signaling

References:

Genotypes:

FYPO:0001799 - cell cycle arrest at mitotic G2/M phase transition during response to DNA damage

References:

Genotypes:

FYPO:0000229 - cut

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0005451 - decreased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009078 - decreased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

References:

Genotypes:

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0006494 - decreased rDNA copy number during vegetative growth

References:

Genotypes:

FYPO:0005939 - decreased replicative lifespan

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0004031 - decreased UV-damage excision repair

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0005258 - increased cell population growth at high temperature

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0001741 - increased chromosomal translocation

References:

Genotypes:

FYPO:0007006 - increased DNA recombination downstream of mitotic DNA replication fork barriers

References:

Genotypes:

FYPO:0003584 - increased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0003588 - increased gross chromosomal rearrangement during replication fork processing

References:

Genotypes:

FYPO:0002604 - increased histone H2A phosphorylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0000473 - increased mitotic recombination

References:

Genotypes:

FYPO:0004709 - increased number of Rad52 foci

References:

Genotypes:

FYPO:0002573 - increased number of Ssb1 foci

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0005704 - loss of viability following cellular response to hydroxyurea

References:

Genotypes:

FYPO:0007142 - loss of viability following cellular response to ionizing radiation

References:

Genotypes:

FYPO:0005705 - loss of viability following cellular response to UV

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0001929 - normal cell cycle regulation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0006319 - normal extent of DNA resection during replication fork processing

References:

Genotypes:

FYPO:0005657 - normal frequency of meiotic crossover associated with gene conversion

References:

Genotypes:

FYPO:0002169 - normal growth during cellular response to gamma radiation

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0004404 - normal growth on JM216

References:

Genotypes:

FYPO:0004410 - normal growth on tetraplatin

References:

Genotypes:

FYPO:0004408 - normal growth on triplatin tetranitrate

References:

Genotypes:

FYPO:0004014 - normal mitotic cell cycle regulation during cellular response to UV

References:

Genotypes:

FYPO:0002102 - normal mitotic DNA damage checkpoint during cellular response to UV

References:

Genotypes:

FYPO:0004245 - normal protein kinase activity during mitotic S phase during cellular response to DNA damage

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002887 - normal protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0006320 - normal replication slippage during replication fork processing

References:

Genotypes:

FYPO:0005787 - normal spatial extent of double-strand break processing

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

References:

Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000102 - sensitive to cisplatin

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0004405 - sensitive to JM335

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0002345 - sensitive to oxaliplatin

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

References:

Genotypes:

FYPO:0007938 - sensitive to tea tree oil

References:

Genotypes:

FYPO:0002328 - sensitive to terbinafine

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00570HRDCHRDC_domPFAM
PF16124RecQ_Zn_bindRecQ_Zn-bdPFAM
PF00270DEADDEAD/DEAH_box_helicase_domPFAM
PF09382RQCRQC_domainPFAM
PF00271Helicase_CHelicase_C-likePFAM
cd17920DEXHc_RecQCDD
cd18794SF2_C_RecQCDD
PS00690DEAH_ATP_HELICASEDNA/RNA_helicase_DEAH_CSPROSITE_PATTERNS
PS51194HELICASE_CTERHelicase_C-likePROSITE_PROFILES
PS51192HELICASE_ATP_BIND_1Helicase_ATP-bdPROSITE_PROFILES
PS50967HRDCHRDC_domPROSITE_PROFILES
SM00490helicmild6Helicase_C-likeSMART
SM00487ultradead3Helicase_ATP-bdSMART
SM00956RQC_2RQC_domainSMART
SM00341hrdc7HRDC_domSMART
G3DSA:3.40.50.300:FF:000296FUNFAM
G3DSA:3.40.50.300:FF:000340FUNFAM
G3DSA:1.10.10.10:FF:000495FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
SSF47819HRDC-likeHRDC-like_sfSUPERFAMILY
G3DSA:1.10.150.80HRDC domainHRDC_dom_sfGENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
G3DSA:1.10.10.10WH-like_DNA-bd_sfGENE3D
PTHR13710DNA HELICASE RECQ FAMILY MEMBERPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMOBIDB-Positive-Polyelectrolyte
TIGR00614recQ_famDNA_helicase_ATP-dep_RecQNCBIFAM

Orthologs

References / Literature

PMID:15226425 - Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.
Nakamura TM et al. Mol Cell Biol 2004 Jul;24(14):6215-30
PMID:19798055 - Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast.
Tinline-Purvis H et al. EMBO J 2009 Nov 04;28(21):3400-12
PMID:15329725 - Separase-mediated cleavage of cohesin at interphase is required for DNA repair.
Nagao K et al. Nature 2004 Aug 26;430(7003):1044-8
PMID:15702347 - The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.
Ahmad F et al. Mol Genet Genomics 2005 Mar;273(1):102-14
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:29697047 - Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks.
Leland BA et al. Elife 2018 Apr 26;7
PMID:9658208 - Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants.
Perego P et al. Mol Pharmacol 1998 Jul;54(1):213-9
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:12724426 - Role for the fission yeast RecQ helicase in DNA repair in G2.
Laursen LV et al. Mol Cell Biol 2003 May;23(10):3692-705
PMID:17660542 - Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.
Dovey CL et al. Genetics 2007 Sep;177(1):47-61
PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.
Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:20705238 - Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange.
Lambert S et al. Mol Cell 2010 Aug 13;39(3):346-59
PMID:25822347 - Role of swi7H4 mutant allele of DNA polymerase α in the DNA damage checkpoint response.
Khan S et al. PLoS One 2015;10(3):e0124063
PMID:25165823 - Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.
Tsutsui Y et al. PLoS Genet 2014 Aug;10(8):e1004542
PMID:38718864 - H2B oncohistones cause homologous recombination defect and genomic instability through reducing H2B monoubiquitination in Schizosaccharomyces pombe.
Qin B et al. J Biol Chem 2024 May 06;:107345
PMID:26093291 - Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.
Habib AG et al. Biochem Biophys Res Commun 2015 Aug 14;464(1):140-6
PMID:31584934 - Histone deposition promotes recombination-dependent replication at arrested forks.
Hardy J et al. PLoS Genet 2019 Oct;15(10):e1008441
PMID:19416828 - Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.
Inagawa T et al. Proc Natl Acad Sci U S A 2009 May 12;106(19):7927-32
PMID:11864600 - Meiotic recombination remote from prominent DNA break sites in S. pombe.
Young JA et al. Mol Cell 2002 Feb;9(2):253-63
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:26465752 - Fission Yeast Exo1 and Rqh1-Dna2 Redundantly Contribute to Resection of Uncapped Telomeres.
Nanbu T et al. PLoS One 2015;10(10):e0140456
PMID:9136000 - The Schizosaccharomyces pombe rec16 gene product regulates multiple meiotic events.
Li YF et al. Genetics 1997 May;146(1):57-67
PMID:16710300 - Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.
Martín V et al. EMBO J 2006 Jun 07;25(11):2564-74
PMID:20040574 - The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.
Lorenz A et al. Nucleic Acids Res 2010 Apr;38(6):1866-73
PMID:12084712 - Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.
Doe CL et al. J Biol Chem 2002 Sep 06;277(36):32753-9
PMID:18031226 - The role of Schizosaccharomyces pombe SUMO ligases in genome stability.
Watts FZ et al. Biochem Soc Trans 2007 Dec;35(Pt 6):1379-84
PMID:26041456 - RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.
Audry J et al. EMBO J 2015 Jul 14;34(14):1942-58
PMID:11027263 - Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.
Snaith HA et al. Mol Cell Biol 2000 Nov;20(21):7922-32
PMID:15485909 - Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.
Morikawa H et al. Mol Cell Biol 2004 Nov;24(21):9401-13
PMID:9566891 - Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene.
Davey S et al. Mol Cell Biol 1998 May;18(5):2721-8
PMID:23297345 - Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.
Nanbu T et al. Mol Cell Biol 2013 Mar;33(6):1175-87
PMID:19205745 - Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.
Yasuhira S Mol Genet Genomics 2009 May;281(5):497-509
PMID:1427071 - Fission yeast genes involved in coupling mitosis to completion of DNA replication.
Enoch T et al. Genes Dev 1992 Nov;6(11):2035-46
PMID:19037101 - Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.
Willis N et al. Mol Biol Cell 2009 Feb;20(3):819-33
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:15340008 - Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.
Win TZ et al. J Cell Sci 2004 Sep 15;117(Pt 20):4769-78
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
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