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protein coding gene - rqh1 (SPAC2G11.12) - RecQ type DNA helicase Rqh1

Gene summary

Standard name
rqh1
Systematic ID
SPAC2G11.12
Product
RecQ type DNA helicase Rqh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
hus2, rad12, rec9
UniProt ID
Q09811
ORFeome ID
39/39D09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 831937..836094 forward strand

Annotation

Complementation

PBO:0017547 - functionally complemented by E. coli RusA

References:

PBO:0128235 - functionally complemented by human BLM

PBO:0024821 - functionally complemented by human GEN1

References:

PBO:0128234 - functionally complemented by human RECQL

PBO:0128236 - functionally complemented by human RECQL4

Disease association

MONDO:0008876 - Bloom syndrome

References:

MONDO:0010196 - Werner syndrome

References:

GO biological process

GO:0006974 - DNA damage response

References:

GO:0006301 - DNA damage tolerance

References:

GO:0000729 - DNA double-strand break processing

References:

GO:0000724 - double-strand break repair via homologous recombination

References:

GO:0043007 - maintenance of rDNA

References:

GO:0031573 - mitotic intra-S DNA damage checkpoint signaling

References:

GO:1990426 - mitotic recombination-dependent replication fork processing

References:

GO:0000725 - recombinational repair

References:

GO:0031297 - replication fork processing

References:

GO:0071140 - resolution of mitotic recombination intermediates

References:

GO:0070914 - UV-damage excision repair

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0000228 - nuclear chromosome

References:

GO:0043596 - nuclear replication fork

References:

GO:0005730 - nucleolus

References:

GO:0005634 - nucleus

References:

GO:0031422 - RecQ family helicase-topoisomerase III complex

References:

GO:0035861 - site of double-strand break

References:

GO molecular function

GO:0043138 - 3'-5' DNA helicase activity

References:

GO:0005524 - ATP binding

References:

GO:0003677 - DNA binding

References:

GO:0009378 - four-way junction helicase activity

References:

Modification

MOD:00595 - monomannosylated residue

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01149 - sumoylated lysine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0002553 - abnormal double-strand break processing

References:

Genotypes:

FYPO:0005658 - abnormal frequency of meiotic crossover associated with gene conversion

References:

Genotypes:

FYPO:0000481 - abnormal mitotic recombination

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0002702 - circularized chromosome

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0001052 - cut, small cell

References:

Genotypes:

FYPO:0005943 - decreased break-induced loss of heterozygosity via chromosomal translocation

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0006318 - decreased DNA resection during replication fork processing

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0005608 - decreased histone H2B-K119 ubiquitination at double-strand break site during vegetative growth

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0005388 - decreased number of Rad51 foci during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0002474 - decreased protein localization to double-strand break site

References:

Genotypes:

FYPO:0003483 - decreased punctate nuclear protein localization during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0003085 - decreased replication fork arrest at mating-type locus

References:

Genotypes:

FYPO:0005939 - decreased replicative lifespan

References:

Genotypes:

FYPO:0005357 - decreased site-specific DNA replication termination at RTS1 barrier

References:

Genotypes:

FYPO:0005786 - decreased spatial extent of double-strand break processing

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0004985 - entangled telomeres during vegetative growth

References:

Genotypes:

FYPO:0005432 - globally decreased mitotic recombination

References:

Genotypes:

FYPO:0005452 - increased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0005944 - increased break-induced loss of heterozygosity via chromosomal truncation

References:

Genotypes:

FYPO:0004251 - increased DNA resection during replication fork processing

References:

Genotypes:

FYPO:0003584 - increased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0005659 - increased frequency of meiotic crossover associated with gene conversion

References:

Genotypes:

FYPO:0004709 - increased number of Rad52 foci

References:

Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0002573 - increased number of Ssb1 foci

References:

Genotypes:

FYPO:0005435 - inviable after spore germination with elongated germ tube and fragmented nucleus

References:

Genotypes:

FYPO:0007140 - inviable after spore germination, multiple cell divisions, swollen, elongated cell

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002150 - inviable spore population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003587 - loss of gross chromosomal rearrangement during replication fork processing

References:

Genotypes:

FYPO:0005704 - loss of viability following cellular response to hydroxyurea

References:

Genotypes:

FYPO:0005705 - loss of viability following cellular response to UV

References:

Genotypes:

FYPO:0006923 - normal DNA recombination frequency at mitotic DNA replication fork barriers

References:

Genotypes:

FYPO:0005392 - normal DNA recombination frequency during cellular response to ionizing radiation

References:

Genotypes:

FYPO:0006319 - normal extent of DNA resection during replication fork processing

References:

Genotypes:

FYPO:0002887 - normal protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0006570 - normal UV-damage excision repair

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0003107 - progressively shortening telomeres during vegetative growth

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002550 - sensitive to UV

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

References:

Genotypes:

FYPO:0002058 - viable cell population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Protein features

PBO:0111747 - DEAD/DEAH box helicase

PBO:0111799 - RecQ family

PBO:0111800 - Req family helicase

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0001933 - abnormal mitotic cell cycle regulation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0000670 - abnormal mitotic sister chromatid separation

References:

Genotypes:

FYPO:0000007 - abnormal S-phase DNA damage checkpoint

References:

Genotypes:

FYPO:0002101 - abolished 3'-5' DNA helicase activity

References:

Genotypes:

FYPO:0004029 - abolished 5' deoxyribonuclease (pyrimidine dimer) activity

References:

Genotypes:

FYPO:0003814 - abolished response to S-phase DNA damage checkpoint signaling

References:

Genotypes:

FYPO:0001799 - cell cycle arrest at mitotic G2/M phase transition during response to DNA damage

References:

Genotypes:

FYPO:0000229 - cut

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0001054 - cut, elongated cell

References:

Genotypes:

FYPO:0005451 - decreased break-induced loss of heterozygosity

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0009078 - decreased cell population growth on ethanol carbon source

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

References:

Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

References:

Genotypes:

FYPO:0003912 - decreased double-strand break repair via homologous recombination

References:

Genotypes:

FYPO:0004360 - decreased duration of mitotic cell cycle DNA replication checkpoint

References:

Genotypes:

FYPO:0004371 - decreased duration of S-phase DNA damage checkpoint

References:

Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0001514 - decreased protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0006494 - decreased rDNA copy number during vegetative growth

References:

Genotypes:

FYPO:0005939 - decreased replicative lifespan

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0004031 - decreased UV-damage excision repair

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001122 - elongated vegetative cell

References:

Genotypes:

FYPO:0005258 - increased cell population growth at high temperature

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0003004 - increased cellular reactive oxygen species level during vegetative growth

References:

Genotypes:

FYPO:0001741 - increased chromosomal translocation

References:

Genotypes:

FYPO:0007006 - increased DNA recombination downstream of mitotic DNA replication fork barriers

References:

Genotypes:

FYPO:0003584 - increased double-strand break repair via nonhomologous end joining

References:

Genotypes:

FYPO:0003588 - increased gross chromosomal rearrangement during replication fork processing

References:

Genotypes:

FYPO:0002604 - increased histone H2A phosphorylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0000473 - increased mitotic recombination

References:

Genotypes:

FYPO:0004709 - increased number of Rad52 foci

References:

Genotypes:

FYPO:0002573 - increased number of Ssb1 foci

References:

Genotypes:

FYPO:0001571 - increased protein-protein interaction

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002303 - inviable mononucleate monoseptate vegetative cell with anucleate compartment

References:

Genotypes:

FYPO:0005704 - loss of viability following cellular response to hydroxyurea

References:

Genotypes:

FYPO:0007142 - loss of viability following cellular response to ionizing radiation

References:

Genotypes:

FYPO:0005705 - loss of viability following cellular response to UV

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0001929 - normal cell cycle regulation during cellular response to hydroxyurea

References:

Genotypes:

FYPO:0006319 - normal extent of DNA resection during replication fork processing

References:

Genotypes:

FYPO:0005657 - normal frequency of meiotic crossover associated with gene conversion

References:

Genotypes:

FYPO:0002169 - normal growth during cellular response to gamma radiation

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0004404 - normal growth on JM216

References:

Genotypes:

FYPO:0004410 - normal growth on tetraplatin

References:

Genotypes:

FYPO:0004408 - normal growth on triplatin tetranitrate

References:

Genotypes:

FYPO:0004014 - normal mitotic cell cycle regulation during cellular response to UV

References:

Genotypes:

FYPO:0002102 - normal mitotic DNA damage checkpoint during cellular response to UV

References:

Genotypes:

FYPO:0004245 - normal protein kinase activity during mitotic S phase during cellular response to DNA damage

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002887 - normal protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0006320 - normal replication slippage during replication fork processing

References:

Genotypes:

FYPO:0006605 - normal S-phase DNA damage checkpoint during cellular response to methyl methanesulfonate

References:

Genotypes:

FYPO:0005787 - normal spatial extent of double-strand break processing

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

References:

Genotypes:

FYPO:0009031 - resistance to bleomycin

References:

Genotypes:

FYPO:0009068 - resistance to ciclopirox olamine

References:

Genotypes:

FYPO:0000764 - resistance to cycloheximide

References:

Genotypes:

FYPO:0009034 - resistance to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0009080 - sensitive to calcofluor and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000102 - sensitive to cisplatin

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0004405 - sensitive to JM335

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0002345 - sensitive to oxaliplatin

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005889 - sensitive to sodium chloride

References:

Genotypes:

FYPO:0007938 - sensitive to tea tree oil

References:

Genotypes:

FYPO:0002328 - sensitive to terbinafine

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0002239 - shortened telomeres during vegetative growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00270DEADDEAD/DEAH_box_helicase_domPfam
PF00271Helicase_CHelicase_C-likePfam
PF00570HRDCHRDC_domPfam
PF09382RQCRQC_domainPfam
PF16124RecQ_Zn_bindRecQ_Zn-bdPfam
cd17920DEXHc_RecQCDD
cd18794SF2_C_RecQCDD
PS00690DEAH_ATP_HELICASEDNA/RNA_helicase_DEAH_CSPROSITE patterns
PS50967HRDCHRDC_domPROSITE profiles
PS51192HELICASE_ATP_BIND_1Helicase_ATP-bdPROSITE profiles
PS51194HELICASE_CTERHelicase_C-likePROSITE profiles
SM00341HRDCHRDC_domSMART
SM00487DEXDcHelicase_ATP-bdSMART
SM00490HELICcHelicase_C-likeSMART
SM00956RQCRQC_domainSMART
G3DSA:1.10.10.10:FF:000495CATH-FunFam
G3DSA:3.40.50.300:FF:000296CATH-FunFam
G3DSA:3.40.50.300:FF:000340CATH-FunFam
G3DSA:1.10.10.10WH-like_DNA-bd_sfCATH-Gene3D
G3DSA:1.10.150.80HRDC_dom_sfCATH-Gene3D
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF47819HRDC-like_sfSUPERFAMILY
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR13710PANTHER
TIGR00614recQ_famDNA_helicase_ATP-dep_RecQNCBIFAM
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity
mobidb-lite-Polardisorder_predictionMobiDB-Polar
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMobiDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:30667359 - Factors affecting template switch recombination associated with restarted DNA replication.
Jalan M et al. Elife 2019 Jan 22;8
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:12023299 - Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III.
Caspari T et al. Genes Dev 2002 May 15;16(10):1195-208
PMID:17762865 - SUMO-targeted ubiquitin ligases in genome stability.
Prudden J et al. EMBO J 2007 Sep 19;26(18):4089-101
PMID:40594858 - Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions.
Bakosova A et al. Sci Rep 2025 Jul 01;15(1):21895
PMID:16303848 - A role for the fission yeast Rqh1 helicase in chromosome segregation.
Win TZ et al. J Cell Sci 2005 Dec 15;118(Pt 24):5777-84
PMID:27098497 - CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
Zeng M et al. Nat Commun 2016 Apr 21;7:11364
PMID:15802523 - A postsynaptic role for Rhp55/57 that is responsible for cell death in Deltarqh1 mutants following replication arrest in Schizosaccharomyces pombe.
Hope JC et al. Genetics 2005 Jun;170(2):519-31
PMID:16710300 - Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.
Martín V et al. EMBO J 2006 Jun 07;25(11):2564-74
PMID:21931565 - Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.
Langerak P et al. PLoS Genet 2011 Sep;7(9):e1002271
PMID:26041456 - RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.
Audry J et al. EMBO J 2015 Jul 14;34(14):1942-58
PMID:18769921 - Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair.
Khasanov FK et al. Curr Genet 2008 Oct;54(4):197-211
PMID:15643072 - Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.
Williams DR et al. Eukaryot Cell 2005 Jan;4(1):166-77
PMID:10373582 - The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance.
Wilson S et al. Nucleic Acids Res 1999 Jul 01;27(13):2655-61
PMID:26465752 - Fission Yeast Exo1 and Rqh1-Dna2 Redundantly Contribute to Resection of Uncapped Telomeres.
Nanbu T et al. PLoS One 2015;10(10):e0140456
PMID:166019 - Genetic control of radiation sensitivity in Schizosaccharomyces pombe.
Nasim A et al. Genetics 1975 Apr;79(4):573-82
PMID:28139976 - An aging-independent replicative lifespan in a symmetrically dividing eukaryote.
Spivey EC et al. Elife 2017 Jan 31;6
PMID:32541066 - RecQ DNA Helicase Rqh1 Promotes Rad3 ATR Kinase Signaling in the DNA Replication Checkpoint Pathway of Fission Yeast.
Ahamad N et al. Mol Cell Biol 2020 Aug 14;40(17)
PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.
Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595
PMID:33427950 - Checkpoint functions of RecQ helicases at perturbed DNA replication fork.
Ahamad N et al. Curr Genet 2021 Jun;67(3):369-382
PMID:26093291 - Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.
Habib AG et al. Biochem Biophys Res Commun 2015 Aug 14;464(1):140-6
PMID:20176980 - Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.
Dolan WP et al. Genetics 2010 May;185(1):39-53
PMID:17307401 - The novel gene mus7(+) is involved in the repair of replication-associated DNA damage in fission yeast.
Yokoyama M et al. DNA Repair (Amst) 2007 Jun 01;6(6):770-80
PMID:22723423 - The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.
Lorenz A et al. Science 2012 Jun 22;336(6088):1585-8
PMID:12084712 - Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.
Doe CL et al. J Biol Chem 2002 Sep 06;277(36):32753-9
PMID:12409469 - The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes.
Maftahi M et al. Nucleic Acids Res 2002 Nov 01;30(21):4781-92
PMID:15340008 - Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity.
Win TZ et al. J Cell Sci 2004 Sep 15;117(Pt 20):4769-78
PMID:16135799 - Role of the Schizosaccharomyces pombe F-Box DNA helicase in processing recombination intermediates.
Morishita T et al. Mol Cell Biol 2005 Sep;25(18):8074-83
PMID:16354704 - Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.
Miyabe I et al. Mol Cell Biol 2006 Jan;26(1):343-53
PMID:12000964 - Cnd2 has dual roles in mitotic condensation and interphase.
Aono N et al. Nature 2002 May 09;417(6885):197-202
PMID:21098121 - Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.
Takahashi K et al. Mol Cell Biol 2011 Feb;31(3):495-506
PMID:23516381 - DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast.
Norman-Axelsson U et al. PLoS Genet 2013;9(3):e1003371
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