protein coding gene - taf1 (SPAC2G11.14) - transcription factor TFIID complex, histone acetyltransferase and histone fold subunit Taf111

Gene summary

Standard name

taf1

Systematic ID

SPAC2G11.14

Product

transcription factor TFIID complex, histone acetyltransferase and histone fold subunit Taf111

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

taf111, taf130, kat4

UniProt ID

Q09813

ORFeome ID

29/29H11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 838238..841562 forward strand

Annotation

Protein features

Orthologs

• TAF1 (HGNC:11535) Homo sapiens
• TAF1L (HGNC:18056) Homo sapiens
• taf1 (SJAG_03900) Schizosaccharomyces japonicus
• TAF1 (YGR274C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:32101745 - Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.

Lee SY et al. Cell Rep 2020 Feb 25;30(8):2686-2698.e8

PMID:9734781 - Defect in cytokinesis of fission yeast induced by mutation in the WD40 repeat motif of a TFIID subunit.

Yamamoto T et al. Genes Cells 1998 Jun;3(6):347-55

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.

Gómez EB et al. Genetics 2008 Jun;179(2):757-71

PMID:10923022 - Mutations in the large subunit of U2AF disrupt pre-mRNA splicing, cell cycle progression and nuclear structure.

Beales M et al. Yeast 2000 Aug;16(11):1001-13

PMID:10871341 - Isolation of an essential Schizosaccharomyces pombe gene, prp31(+), that links splicing and meiosis.

Bishop DT et al. Nucleic Acids Res 2000 Jun 01;28(11):2214-20

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:11972332 - Identification of histone H4-like TAF in Schizosaccharomyces pombe as a protein that interacts with WD repeat-containing TAF.

Mitsuzawa H et al. Nucleic Acids Res 2002 May 01;30(9):1952-8

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.

PMID:11350031 - Mutation in the prp12+ gene encoding a homolog of SAP130/SF3b130 causes differential inhibition of pre-mRNA splicing and arrest of cell-cycle progression in Schizosaccharomyces pombe.

Habara Y et al. RNA 2001 May;7(5):671-81

GO_REF:0000002 - Comments

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:12682361 - The fission yeast TFIIB-related factor limits RNA polymerase III to a TATA-dependent pathway of TBP recruitment.

Huang Y et al. Nucleic Acids Res 2003 Apr 15;31(8):2108-16

PMID:11279037 - Two WD repeat-containing TATA-binding protein-associated factors in fission yeast that suppress defects in the anaphase-promoting complex.

Mitsuzawa H et al. J Biol Chem 2001 May 18;276(20):17117-24

PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:11252721 - Fission yeast Prp4p kinase regulates pre-mRNA splicing by phosphorylating a non-SR-splicing factor.

Schwelnus W et al. EMBO Rep 2001 Jan;2(1):35-41

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .

Budden AM et al. Elife 2023 Aug 24;12

PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.

Li Y et al. Science 1994 Feb 11;263(5148):805-7

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:24868378 - X-linked dystonia parkinsonism: clinical phenotype, genetics and therapeutics.

Rosales RL J Mov Disord 2010 Oct;3(2):32-8

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:19913479 - Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID.

Elmlund H et al. Structure 2009 Nov 11;17(11):1442-52