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protein coding gene - gto2 (SPAC30D11.01c) - extracellular alpha-glucosidase Gto2

Gene summary

Standard name
gto2
Systematic ID
SPAC30D11.01c
Product
extracellular alpha-glucosidase Gto2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPAC56F8.01
UniProt ID
Q09901
ORFeome ID
47/47F07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1119996..1123773 forward strand

Annotation

Disease association

MONDO:0009114 - congenital sucrase-isomaltase deficiency

References:

MONDO:0002412 - disorder of glycogen metabolism

References:

MONDO:0017694 - glycogen storage disease due to acid maltase deficiency, infantile onset

References:

MONDO:0018485 - glycogen storage disease due to acid maltase deficiency, late-onset

References:

MONDO:0009290 - glycogen storage disease II

References:

MONDO:0005066 - metabolic disease

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GO biological process

GO:0009313 - oligosaccharide catabolic process

References:

GO:0000272 - polysaccharide catabolic process

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GO cellular component

GO:0009986 - cell surface

References:

GO:0005576 - extracellular region

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GO molecular function

GO:0004558 - alpha-1,4-glucosidase activity

References:

GO:0030246 - carbohydrate binding

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Modification

MOD:00006 - N-glycosylated residue

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Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0001175 - normal growth on maltose carbon source

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF01055Glyco_hydro_31_2ndGlyco_hydro_31_TIMPfam
PF21365Glyco_hydro_31_3rdGlyco_hydro_31_CPfam
cd06602GH31_MGAM_SI_GAACDD
cd14752GH31_NCDD
PS00707GLYCOSYL_HYDROL_F31_2Glyco_hydro_31_CSPROSITE patterns
G3DSA:2.60.40.1180:FF:000001CATH-FunFam
G3DSA:2.60.40.1760:FF:000005CATH-FunFam
G3DSA:3.20.20.80:FF:000138CATH-FunFam
G3DSA:3.20.20.80:FF:000169CATH-FunFam
G3DSA:2.60.40.1180Glyco_hydro_bCATH-Gene3D
G3DSA:2.60.40.1760CATH-Gene3D
G3DSA:3.20.20.80CATH-Gene3D
SSF51011SUPERFAMILY
SSF51445GH_hydrolase_sfSUPERFAMILY
SSF74650Gal_mutarotase_sf_domSUPERFAMILY
PTHR22762PANTHER
Signal PeptideDeepTMHMM-Signal-Peptide

Orthologs

References / Literature

PMID:10759889 - Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.
Ding DQ et al. Genes Cells 2000 Mar;5(3):169-90
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:24224056 - The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.
Kato H et al. PLoS One 2013;8(11):e80572
PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.
Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:39660919 - Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation.
Innokentev A et al. mBio 2024 Dec 11;:e0299224
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .
Guydosh NR et al. Elife 2017 Sep 25;6
PB_REF:0000003 - Disease Association Curation
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments