protein coding gene - nth1 (SPAC30D11.07) - DNA endonuclease III

Gene summary

Standard name

nth1

Systematic ID

SPAC30D11.07

Product

DNA endonuclease III

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09907

ORFeome ID

16/16D03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1106430..1107876 reverse strand

Annotation

Protein features

Orthologs

• NTHL1 (HGNC:8028) Homo sapiens
• nth1 (SJAG_03724) Schizosaccharomyces japonicus
• NTG1 (YAL015C) Saccharomyces cerevisiae
• NTG2 (YOL043C) Saccharomyces cerevisiae

References / Literature

PMID:18042546 - Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe.

Cuthbertson BJ et al. J Biol Chem 2008 Feb 01;283(5):2586-94

PMID:27255861 - Genetic evidence for involvement of membrane trafficking in the action of 5-fluorouracil.

Hu L et al. Fungal Genet Biol 2016 Aug;93:17-24

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62

PMID:26628015 - Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Zhang X et al. Kobe J Med Sci 2015 Oct 09;61(2):E54-63

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:16076563 - Roles of base excision repair enzymes Nth1p and Apn2p from Schizosaccharomyces pombe in processing alkylation and oxidative DNA damage.

Sugimoto T et al. DNA Repair (Amst) 2005 Nov 21;4(11):1270-80

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

GO_REF:0000002 - Comments

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:21670547 - Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage.

Kanamitsu K et al. Genes Genet Syst 2011;86(2):83-91

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:22748672 - Polynucleotide kinase/phosphatase, Pnk1, is involved in base excision repair in Schizosaccharomyces pombe.

Kashkina E et al. DNA Repair (Amst) 2012 Aug 01;11(8):676-83

PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.

Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:22084197 - AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe.

Nilsen L et al. Nucleic Acids Res 2012 Mar;40(5):2000-9

PMID:36793083 - The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.

Mahrik L et al. Epigenetics Chromatin 2023 Feb 16;16(1):6

PMID:17641464 - Recombinant Schizosaccharomyces pombe Nth1 protein exhibits DNA glycosylase activities for 8-oxo-7,8-dihydroguanine and thymine residues oxidized in the methyl group.

Yonekura S et al. J Radiat Res 2007 Sep;48(5):417-24

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:9425081 - Substrate specificity of Schizosaccharomyces pombe Nth protein for products of oxidative DNA damage.

Karahalil B et al. Biochemistry 1998 Jan 13;37(2):590-5

PMID:23245849 - Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2.

Dalhus B et al. Structure 2013 Jan 08;21(1):154-166

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:8811082 - Molecular cloning and functional analysis of a Schizosaccharomyces pombe homologue of Escherichia coli endonuclease III.

Roldán-Arjona T et al. Nucleic Acids Res 1996 Sep 01;24(17):3307-12

PMID:16857169 - The role of Schizosaccharomyces pombe DNA repair enzymes Apn1p and Uve1p in the base excision repair of apurinic/apyrimidinic sites.

Tanihigashi H et al. Biochem Biophys Res Commun 2006 Sep 08;347(4):889-94

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25293972 - Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL et al. Genetics 2014 Dec;198(4):1457-72

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:29635344 - Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast.

Lim KK et al. Nucleic Acids Res 2018 Jun 01;46(10):5061-5074

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

GO_REF:0000051 - S. pombe keyword mapping

PMID:12675805 - A new Schizosaccharomyces pombe base excision repair mutant, nth1, reveals overlapping pathways for repair of DNA base damage.

Osman F et al. Mol Microbiol 2003 Apr;48(2):465-80

PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.

Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:17277362 - Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.

Lee KM et al. Genetics 2007 Apr;175(4):1585-95

PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.

Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58

PMID:29856841 - Genome-wide screen reveals important roles for ESCRT proteins in drug/ion resistance of fission yeast.

Yang Y et al. PLoS One 2018;13(6):e0198516

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:15722486 - Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe.

Alseth I et al. Nucleic Acids Res 2005;33(3):1123-31

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:28945192 - Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe .

Guydosh NR et al. Elife 2017 Sep 25;6

PMID:21183410 - Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Vejrup-Hansen R et al. DNA Repair (Amst) 2011 Mar 07;10(3):283-95

PMID:18270439 - Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe.

Kanamitsu K et al. Genes Genet Syst 2007 Dec;82(6):489-94