protein coding gene - rad52 (SPAC30D11.10) - DNA recombination mediator Rad52 (previously Rad22)

Gene summary

Standard name

rad52

Systematic ID

SPAC30D11.10

Product

DNA recombination mediator Rad52 (previously Rad22)

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

rad22A, rad22

UniProt ID

P36592

ORFeome ID

23/23B03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 1099489..1101563 reverse strand

Annotation

Protein features

Orthologs

• RAD52 (HGNC:9824) Homo sapiens
• rad52 (SJAG_02079) Schizosaccharomyces japonicus
• RAD52 (YML032C) Saccharomyces cerevisiae

References / Literature

PMID:19158664 - Smc5/6 maintains stalled replication forks in a recombination-competent conformation.

Irmisch A et al. EMBO J 2009 Jan 21;28(2):144-55

PMID:15226425 - Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM et al. Mol Cell Biol 2004 Jul;24(14):6215-30

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016

PMID:15359282 - Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.

Xhemalce B et al. EMBO J 2004 Oct 01;23(19):3844-53

PMID:10373582 - The role of Schizosaccharomyces pombe Rad32, the Mre11 homologue, and other DNA damage response proteins in non-homologous end joining and telomere length maintenance.

Wilson S et al. Nucleic Acids Res 1999 Jul 01;27(13):2655-61

PMID:9826747 - Schizosaccharomyces pombe rad32 protein: a phosphoprotein with an essential phosphoesterase motif required for repair of DNA double strand breaks.

Wilson S et al. Nucleic Acids Res 1998 Dec 01;26(23):5261-9

PMID:31855181 - The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast.

Wong IN et al. Elife 2019 Dec 19;8

PMID:11104907 - Characterization of RAD52 homologs in the fission yeast Schizosaccharomyces pombe.

van den Bosch M et al. Mutat Res 2001 Jan 05;461(4):311-23

PMID:15486206 - DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.

Doe CL et al. Nucleic Acids Res 2004;32(18):5570-81

PMID:27697832 - Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation.

Onaka AT et al. Nucleic Acids Res 2016 Dec 15;44(22):10744-10757

PMID:28334931 - Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast.

Manjón E et al. Nucleic Acids Res 2017 May 19;45(9):5269-5284

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:18180284 - Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.

Bailis JM et al. Mol Cell Biol 2008 Mar;28(5):1724-38

PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.

Gómez EB et al. Genetics 2008 Jun;179(2):757-71

PMID:28922417 - Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.

Sanchez A et al. PLoS Genet 2017 Sep;13(9):e1007013

PMID:15336631 - Identification and characterization of the rlp1+, the novel Rad51 paralog in the fission yeast Schizosaccharomyces pombe.

Khasanov FK et al. DNA Repair (Amst) 2004 Oct 05;3(10):1363-74

PMID:31833215 - Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.

Shetty M et al. Aging Cell 2020 Feb;19(2):e13068

PMID:28490498 - Shelterin components mediate genome reorganization in response to replication stress.

Mizuguchi T et al. Proc Natl Acad Sci U S A 2017 May 23;114(21):5479-5484

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:27738016 - RNA interference is essential for cellular quiescence.

Roche B et al. Science 2016 Nov 11;354(6313)

PMID:28475874 - Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.

Ait Saada A et al. Mol Cell 2017 May 04;66(3):398-410.e4

PMID:12930956 - Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer.

Kibe T et al. Nucleic Acids Res 2003 Sep 01;31(17):5054-63

PMID:24265825 - Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response.

Køhler JB et al. PLoS One 2013;8(11):e80442

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:2598273 - Some of the swi genes of Schizosaccharomyces pombe also have a function in the repair of radiation damage.

Schmidt H et al. Curr Genet 1989 Aug;16(2):89-94

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26682798 - The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.

Aronica L et al. Nucleic Acids Res 2016 Feb 29;44(4):1703-17

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:7254221 - Spontaneous and UV-induced recombination in radiation-sensitive mutants of Schizosaccharomyces pombe.

Grossenbacher-Grunder AM et al. Mutat Res 1981 Mar;81(1):37-48

PMID:11884628 - Differential expression and requirements for Schizosaccharomyces pombe RAD52 homologs in DNA repair and recombination.

van den Bosch M et al. Nucleic Acids Res 2002 Mar 15;30(6):1316-24

PMID:20299455 - The fission yeast inhibitor of growth (ING) protein Png1p functions in response to DNA damage.

Chen JQ et al. J Biol Chem 2010 May 21;285(21):15786-93

PMID:28586299 - Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication.

Morrow CA et al. Elife 2017 Jun 06;6

PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238

PMID:17660542 - Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.

Dovey CL et al. Genetics 2007 Sep;177(1):47-61

PMID:29898918 - Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe .

Sanyal S et al. J Cell Sci 2018 Jul 06;131(13)

PMID:37237082 - Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere.

Mongia P et al. Commun Biol 2023 May 26;6(1):551

PMID:8709952 - The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.

Hegde V et al. Mol Gen Genet 1996 Jun 24;251(4):483-92

PMID:16467377 - Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease.

Coulon S et al. Mol Biol Cell 2006 Apr;17(4):2081-90

PMID:12628934 - Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.

Prudden J et al. EMBO J 2003 Mar 17;22(6):1419-30

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:166019 - Genetic control of radiation sensitivity in Schizosaccharomyces pombe.

Nasim A et al. Genetics 1975 Apr;79(4):573-82

PMID:19037101 - Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Willis N et al. Mol Biol Cell 2009 Feb;20(3):819-33

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:34292936 - Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.

Su J et al. PLoS Genet 2021 Jul;17(7):e1009671

PMID:9658208 - Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants.

Perego P et al. Mol Pharmacol 1998 Jul;54(1):213-9

PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Garg M et al. EMBO Rep 2014 Aug;15(8):871-7

PMID:18031226 - The role of Schizosaccharomyces pombe SUMO ligases in genome stability.

Watts FZ et al. Biochem Soc Trans 2007 Dec;35(Pt 6):1379-84

PMID:39789818 - SRPKs Homolog Dsk1 Regulates Homologous Recombination Repair in Schizosaccharomyces pombe.

Lu G et al. Genes Cells 2025 Jan;30(1):e13192

PMID:18416603 - Reconstitution of DNA strand exchange mediated by Rhp51 recombinase and two mediators.

Kurokawa Y et al. PLoS Biol 2008 Apr 15;6(4):e88

PMID:15238514 - Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts.

Young JA et al. Genetics 2004 Jun;167(2):593-605

PMID:14551247 - Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks.

Catlett MG et al. Mol Biol Cell 2003 Nov;14(11):4707-20

PMID:23211746 - Initiation of DNA damage responses through XPG-related nucleases.

Kuntz K et al. EMBO J 2013 Jan 23;32(2):290-302

PMID:22036784 - Purification and functional inactivation of the fission yeast MCM(MCM-BP) complex.

Li JJ et al. FEBS Lett 2011 Dec 15;585(24):3850-5

PMID:18388861 - Mus81 is essential for sister chromatid recombination at broken replication forks.

Roseaulin L et al. EMBO J 2008 May 07;27(9):1378-87

PMID:17724078 - Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.

Cullen JK et al. Mol Cell Biol 2007 Nov;27(21):7745-57

GO_REF:0000051 - S. pombe keyword mapping

PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89

PMID:23779158 - The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination.

Saito Y et al. Sci Rep 2013;3:2022

PMID:28977643 - Regulation of mitotic recombination between DNA repeats in centromeres.

Zafar F et al. Nucleic Acids Res 2017 Nov 02;45(19):11222-11235

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:11172711 - The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions.

Ferreira MG et al. Mol Cell 2001 Jan;7(1):55-63

PMID:7623848 - An alternative eukaryotic DNA excision repair pathway.

Freyer GA et al. Mol Cell Biol 1995 Aug;15(8):4572-7

PMID:20885790 - Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Cavero S et al. PLoS Genet 2010 Sep 23;6(9):e1001138

PMID:27304859 - Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.

Polakova S et al. PLoS Genet 2016 Jun;12(6):e1006102

PMID:10956666 - Rad22 protein, a rad52 homologue in Schizosaccharomyces pombe, binds to DNA double-strand breaks.

Kim WJ et al. J Biol Chem 2000 Nov 10;275(45):35607-11

PMID:26890608 - A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Gaspa L et al. Cell Cycle 2016;15(5):720-9

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:31542296 - Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast.

Yan Z et al. Mol Cell 2019 Dec 05;76(5):699-711.e6

PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.

Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.

Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58

PMID:24748152 - Fission yeast Rad52 phosphorylation restrains error prone recombination pathways.

Bellini A et al. PLoS One 2014;9(4):e95788

PMID:21149262 - A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations.

Sun W et al. Nucleic Acids Res 2011 Mar;39(5):1718-31

PMID:29622660 - RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.

Zhao H et al. EMBO Rep 2018 May;19(5)

PMID:10430583 - A new recombinational DNA repair gene from Schizosaccharomyces pombe with homology to Escherichia coli RecA.

Khasanov FK et al. Genetics 1999 Aug;152(4):1557-72

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:17208257 - Schizosaccharomyces pombe Rad22A and Rad22B have similar biochemical properties and form multimeric structures.

de Vries FA et al. Mutat Res 2007 Feb 03;615(1-2):143-52

PMID:12419233 - Increased recombination intermediates and homologous integration hot spots at DNA replication origins.

Segurado M et al. Mol Cell 2002 Oct;10(4):907-16

PMID:22084197 - AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe.

Nilsen L et al. Nucleic Acids Res 2012 Mar;40(5):2000-9

PMID:22366461 - Brc1-dependent recovery from replication stress.

Bass KL et al. J Cell Sci 2012 Jun 01;125(Pt 11):2753-64

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:29123917 - The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast.

Moiseeva V et al. Cell Discov 2017;3:17041

PMID:31131414 - Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation.

Inoue H et al. Nucleic Acids Res 2019 Jul 26;47(13):6871-6884

PMID:27098497 - CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.

Zeng M et al. Nat Commun 2016 Apr 21;7:11364

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:11292845 - Gain- and loss-of-function of Rhp51, a Rad51 homolog in fission yeast, reveals dissimilarities in chromosome integrity.

Kim WJ et al. Nucleic Acids Res 2001 Apr 15;29(8):1724-32

PMID:23093942 - Recovery of arrested replication forks by homologous recombination is error-prone.

Iraqui I et al. PLoS Genet 2012;8(10):e1002976

PMID:30155942 - Sfh1, an essential component of the RSC chromatin remodeling complex, maintains genome integrity in fission yeast.

Kotomura N et al. Genes Cells 2018 Sep;23(9):738-752

PMID:22645654 - Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Akai Y et al. Open Biol 2011 Dec;1(4):110023

PMID:12930957 - Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.

Meister P et al. Nucleic Acids Res 2003 Sep 01;31(17):5064-73

PMID:20679485 - BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.

Sofueva S et al. Mol Cell Biol 2010 Oct;30(19):4732-43

PMID:26041456 - RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.

Audry J et al. EMBO J 2015 Jul 14;34(14):1942-58

PMID:39252397 - RNA-DNA hybrids on protein coding genes are stabilized by loss of RNase H and are associated with DNA damages during S-phase in fission yeast.

Sagi T et al. Genes Cells 2024 Sep 09;

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:17690116 - Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.

Fersht N et al. Nucleic Acids Res 2007;35(16):5323-37

PMID:28481910 - PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast.

Daigaku Y et al. PLoS Genet 2017 May;13(5):e1006789

PMID:16135800 - The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.

Osman F et al. Mol Cell Biol 2005 Sep;25(18):8084-96

PMID:18160711 - Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.

Subramanian L et al. Mol Cell Biol 2008 Mar;28(5):1443-55

PMID:20705238 - Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange.

Lambert S et al. Mol Cell 2010 Aug 13;39(3):346-59

PMID:23628481 - A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Yu Y et al. DNA Repair (Amst) 2013 Jun 01;12(6):433-43

PMID:19819763 - Mms1-Mms22 complex protects genome integrity in Schizosaccharomyces pombe.

Dovey CL et al. DNA Repair (Amst) 2009 Dec 03;8(12):1390-9

PMID:11726502 - Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair.

Hartsuiker E et al. EMBO J 2001 Dec 03;20(23):6660-71

PMID:19798055 - Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast.

Tinline-Purvis H et al. EMBO J 2009 Nov 04;28(21):3400-12

PMID:22426535 - The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability.

Steinacher R et al. Genes Dev 2012 Mar 15;26(6):594-602

PMID:10512870 - A double-strand break repair component is essential for S phase completion in fission yeast cell cycling.

Suto K et al. Mol Biol Cell 1999 Oct;10(10):3331-43

PMID:18722173 - Chromosome fusions following telomere loss are mediated by single-strand annealing.

Wang X et al. Mol Cell 2008 Aug 22;31(4):463-473

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:20094029 - gammaH2A binds Brc1 to maintain genome integrity during S-phase.

Williams JS et al. EMBO J 2010 Mar 17;29(6):1136-48

PMID:24741789 - Rad51 overexpression and resistance to genotoxic agents. A study in the fission yeast Schizosaccharomyces pombe.

Stanescu RS et al. Rev Med Chir Soc Med Nat Iasi 2014;118(1):133-40

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:32355220 - DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres.

Onaka AT et al. Commun Biol 2020 Apr 30;3(1):202

PMID:11560889 - Multiple interactions among the components of the recombinational DNA repair system in Schizosaccharomyces pombe.

Tsutsui Y et al. Genetics 2001 Sep;159(1):91-105

PMID:19205745 - Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.

Yasuhira S Mol Genet Genomics 2009 May;281(5):497-509

PMID:12050150 - Physical interaction between recombinational proteins Rhp51 and Rad22 in Schizosaccharomyces pombe.

Kim WJ et al. J Biol Chem 2002 Aug 16;277(33):30264-70

PMID:23703609 - TORC2 is required to maintain genome stability during S phase in fission yeast.

Schonbrun M et al. J Biol Chem 2013 Jul 05;288(27):19649-60

PMID:11057444 - The genetic control of spontaneous and UV-induced mitotic intrachromosomal recombination in the fission yeast Schizosaccharomyces pombe.

Osman F et al. Curr Genet 2000 Oct;38(3):113-25

PMID:17307401 - The novel gene mus7(+) is involved in the repair of replication-associated DNA damage in fission yeast.

Yokoyama M et al. DNA Repair (Amst) 2007 Jun 01;6(6):770-80

PMID:24943839 - A role for nuclear envelope-bridging complexes in homology-directed repair.

Swartz RK et al. Mol Biol Cell 2014 Aug 15;25(16):2461-71

PMID:30104346 - Mre11 complex links sister chromatids to promote repair of a collapsed replication fork.

Zhu M et al. Proc Natl Acad Sci U S A 2018 Aug 28;115(35):8793-8798

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:12724426 - Role for the fission yeast RecQ helicase in DNA repair in G2.

Laursen LV et al. Mol Cell Biol 2003 May;23(10):3692-705

PMID:33159083 - The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal.

Kramarz K et al. Nat Commun 2020 Nov 06;11(1):5643

PMID:9870697 - Differential effects of caffeine on DNA damage and replication cell cycle checkpoints in the fission yeast Schizosaccharomyces pombe.

Osman F et al. Mol Gen Genet 1998 Nov;260(4):319-34

PMID:30796050 - Ssu72 phosphatase is a conserved telomere replication terminator.

Escandell JM et al. EMBO J 2019 Apr 01;38(7)

PMID:11452021 - Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.

Wang SW et al. Nucleic Acids Res 2001 Jul 15;29(14):2963-72

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:29422503 - LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.

Mennie AK et al. Nat Commun 2018 Feb 08;9(1):586

PMID:24186976 - Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.

Murayama Y et al. Genes Dev 2013 Nov 01;27(21):2299-304

PMID:12620220 - The telomere protein Taz1 is required to prevent and repair genomic DNA breaks.

Miller KM et al. Mol Cell 2003 Feb;11(2):303-13

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:11600706 - SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52.

Ho JC et al. Nucleic Acids Res 2001 Oct 15;29(20):4179-86

PMID:21183410 - Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Vejrup-Hansen R et al. DNA Repair (Amst) 2011 Mar 07;10(3):283-95

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:12597774 - Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation.

Ho JC et al. Biochem J 2003 May 15;372(Pt 1):97-104

PMID:8290356 - The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae.

Ostermann K et al. Nucleic Acids Res 1993 Dec 25;21(25):5940-4

PMID:15367656 - Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.

Noguchi E et al. Mol Cell Biol 2004 Oct;24(19):8342-55