protein coding gene - cuf1 (SPAC31A2.11c) - DNA-binding transcription factor, nutritional copper sensing Cuf1

Gene summary

Standard name

cuf1

Systematic ID

SPAC31A2.11c

Product

DNA-binding transcription factor, nutritional copper sensing Cuf1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09728

ORFeome ID

19/19G01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome I: 407714..409845 reverse strand

Annotation

Protein features

Orthologs

• cuf1 (SJAG_00802) Schizosaccharomyces japonicus
• CUP2 (YGL166W) Saccharomyces cerevisiae
• MAC1 (YMR021C) Saccharomyces cerevisiae
• HAA1 (YPR008W) Saccharomyces cerevisiae

References / Literature

PMID:27558664 - Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Guo L et al. G3 (Bethesda) 2016 Oct 13;6(10):3317-3333

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842

PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.

Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.

Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72

PMID:30148840 - Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks.

Ganguly A et al. PLoS Genet 2018 Aug;14(8):e1007595

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:16467469 - Copper induces cytoplasmic retention of fission yeast transcription factor cuf1.

Beaudoin J et al. Eukaryot Cell 2006 Feb;5(2):277-92

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:28882432 - Analysis of ambient pH stress response mediated by iron and copper intake in Schizosaccharomyces pombe.

Higuchi Y et al. J Biosci Bioeng 2018 Jan;125(1):92-96

PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39

PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.

Vachon L et al. Genetics 2013 Aug;194(4):873-84

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:28572514 - Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination.

Plante S et al. J Biol Chem 2017 Jul 14;292(28):11896-11914

PMID:11274192 - Identification of a novel high affinity copper transport complex in the fission yeast Schizosaccharomyces pombe.

Zhou H et al. J Biol Chem 2001 Jun 08;276(23):20529-35

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:39747188 - PhpC NF-Y transcription factor infiltrates heterochromatin to generate cryptic intron-containing transcripts crucial for small RNA production.

Srivastav MK et al. Nat Commun 2025 Jan 02;16(1):268

PMID:17477863 - Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.

Rustici G et al. Genome Biol 2007;8(5):R73

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.

Materne P et al. Elife 2015 Jun 22;4:e09008

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:10593913 - A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe.

Labbé S et al. J Biol Chem 1999 Dec 17;274(51):36252-60

PMID:24569997 - Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.

Plante S et al. J Biol Chem 2014 Apr 04;289(14):10168-81

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:12244050 - Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe.

Bellemare DR et al. J Biol Chem 2002 Nov 29;277(48):46676-86

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:12578838 - The Schizosaccharomyces pombe Cuf1 is composed of functional modules from two distinct classes of copper metalloregulatory transcription factors.

Beaudoin J et al. J Biol Chem 2003 Apr 18;278(16):14565-77

PMID:21965289 - Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.

Buttrick GJ et al. Mol Biol Cell 2011 Dec;22(23):4486-502

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:17384198 - Crm1-mediated nuclear export of the Schizosaccharomyces pombe transcription factor Cuf1 during a shift from low to high copper concentrations.

Beaudoin J et al. Eukaryot Cell 2007 May;6(5):764-75

PMID:18723604 - Copper distributed by Atx1 is available to copper amine oxidase 1 in Schizosaccharomyces pombe.

Peter C et al. Eukaryot Cell 2008 Oct;7(10):1781-94

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;