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protein coding gene - dpm1 (SPAC31G5.16c) - dolichyl-phosphate beta-D-mannosyltransferase catalytic subunit Dpm1

Gene summary

Standard name
dpm1
Systematic ID
SPAC31G5.16c
Product
dolichyl-phosphate beta-D-mannosyltransferase catalytic subunit Dpm1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14466
ORFeome ID
10/10H03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3014389..3018798 reverse strand

Annotation

Complementation

PBO:0013781 - functionally complemented by T. reesei dpm1

References:

Disease association

MONDO:0015286 - congenital disorder of glycosylation

References:

MONDO:0012123 - congenital disorder of glycosylation type 1E

References:

MONDO:0005066 - metabolic disease

References:

GO biological process

GO:0180047 - dolichol phosphate mannose biosynthetic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0033185 - dolichol-phosphate-mannose synthase complex

References:

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

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GO molecular function

GO:0004582 - dolichyl-phosphate beta-D-mannosyltransferase activity

References:

GO:0046872 - metal ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00535Glycos_transf_2Glyco_trans_2-likePfam
cd06442DPM1_likeDPM1-likeCDD
G3DSA:3.90.550.10:FF:000036CATH-FunFam
G3DSA:3.90.550.10Nucleotide-diphossugar_transCATH-Gene3D
SSF53448Nucleotide-diphossugar_transSUPERFAMILY
PTHR43398DPM1-likePANTHER

Orthologs

References / Literature

PMID:9223280 - Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe.
Colussi PA et al. Proc Natl Acad Sci U S A 1997 Jul 22;94(15):7873-8
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:11030744 - Dolichol phosphate mannose synthase from the filamentous fungus Trichoderma reesei belongs to the human and Schizosaccharomyces pombe class of the enzyme.
Kruszewska JS et al. Glycobiology 2000 Oct;10(10):983-91
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:10835346 - Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.
Maeda Y et al. EMBO J 2000 Jun 01;19(11):2475-82
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000003 - Disease Association Curation
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36