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protein coding gene - uba5 (SPAC323.06c) - NEDD8 activating enzyme E1-type Uba5

Gene summary

Standard name
uba5
Systematic ID
SPAC323.06c
Product
NEDD8 activating enzyme E1-type Uba5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UT93
ORFeome ID
26/26G01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 3915560..3917582 reverse strand

Annotation

Disease association

MONDO:0014933 - developmental and epileptic encephalopathy, 44

References:

MONDO:0859361 - neurodevelopmental disorder with dysmorphic facies and ischiopubic hypoplasia

References:

GO biological process

GO:0045116 - protein neddylation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0019781 - NEDD8 activating enzyme activity

References:

Modification

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:01148 - ubiquitinylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00899ThiFThiF_NAD_FAD-bdPfam
cd01493APPBP1_RUBCDD
G3DSA:3.40.50.720:FF:000475CATH-FunFam
G3DSA:3.40.50.720:FF:000860CATH-FunFam
G3DSA:3.40.50.720CATH-Gene3D
SSF69572Ubiquitin-activating_enzSUPERFAMILY
PTHR10953ThiF/MoeB/HesAPANTHER
PIRSF039099APP-BP1APP-BP1PIRSF
CoilCOILS

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PB_REF:0000003 - Disease Association Curation
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:19805578 - Genome-wide mapping of myosin protein-RNA networks suggests the existence of specialized protein production sites.
Mata J FASEB J 2010 Feb;24(2):479-84
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323