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protein coding gene - tbc1 (SPAC328.08c) - tubulin specific chaperone cofactor C, GTPase activating protein Tbc1

Gene summary

Standard name
tbc1
Systematic ID
SPAC328.08c
Product
tubulin specific chaperone cofactor C, GTPase activating protein Tbc1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P3T8
ORFeome ID
17/17A12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3492589..3494572 reverse strand

Annotation

Disease association

MONDO:0019200 - retinitis pigmentosa

References:

MONDO:0010723 - retinitis pigmentosa 2

References:

GO biological process

GO:0007023 - post-chaperonin tubulin folding pathway

References:

GO:0006457 - protein folding

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO molecular function

GO:0005096 - GTPase activator activity

References:

GO:0005515 - protein binding

References:

Multi-locus phenotype

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000016 - curved vegetative cell

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

References:

Genotypes:

FYPO:0002462 - inviable branched, elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002004 - microtubules absent from cell

References:

Genotypes:

FYPO:0000091 - sensitive to thiabendazole

References:

Genotypes:

FYPO:0002760 - short cytoplasmic microtubules

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07986TBCCTubulin-bd_cofactor_C_domPfam
PS51329C_CAP_COFACTOR_CC-CAP_CF_C-likePROSITE profiles
SM00673CARPCARP_motifSMART
G3DSA:1.20.58.1250TBCC_N_sfCATH-Gene3D
G3DSA:2.160.20.70CAP/MinC_CCATH-Gene3D
PTHR15139TBCCPANTHER
CoilCOILS

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22146723 - Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.
Ikebe C et al. Biosci Biotechnol Biochem 2011;75(12):2364-70
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23576550 - The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2.
Mori R et al. Mol Biol Cell 2013 Jun;24(11):1713-24, S1-8
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PB_REF:0000003 - Disease Association Curation