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protein coding gene - erg8 (SPAC343.01c) - phosphomevalonate kinase Erg8

Gene summary

Standard name
erg8
Systematic ID
SPAC343.01c
Product
phosphomevalonate kinase Erg8
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UT88
ORFeome ID
20/20G11
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome I: 1638544..1641196 reverse strand

Annotation

Disease association

MONDO:0009849 - hyperimmunoglobulinemia D with periodic fever

References:

MONDO:0012481 - mevalonic aciduria

References:

MONDO:0008293 - porokeratosis 3, disseminated superficial actinic type

References:

GO biological process

GO:0006696 - ergosterol biosynthetic process

References:

GO:0010142 - farnesyl diphosphate biosynthetic process, mevalonate pathway

References:

GO:0019287 - isopentenyl diphosphate biosynthetic process, mevalonate pathway

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

References:

GO:0005777 - peroxisome

References:

GO molecular function

GO:0004631 - phosphomevalonate kinase activity

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003374 - normal cellular coenzyme Q10 level

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
G3DSA:3.30.230.10:FF:000069FUNFAM
SSF54211Ribosomal protein S5 domain 2-likeRibosomal_Su5_D2-typ_SFSUPERFAMILY
G3DSA:3.30.230.10Ribsml_uS5_D2-typ_fold_subgrGENE3D
G3DSA:3.30.70.890GHMP_kinase_C_sfGENE3D
PTHR31814Phosphomevalonate_kinasePANTHER
PIRSF017288PMK_GHMP_eukErg8PIRSF
TIGR01219Pmev_kin_ERG8Erg8NCBIFAM

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25647499 - Production of CoQ10 in fission yeast by expression of genes responsible for CoQ10 biosynthesis.
Moriyama D et al. Biosci Biotechnol Biochem 2015;79(6):1026-33
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37156916 - Fast and accurate protein structure search with Foldseek.
van Kempen M et al. Nat Biotechnol 2024 Feb;42(2):243-246