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protein coding gene - apc11 (SPAC343.03) - anaphase-promoting complex ubiquitin -protein ligase E3 subunit Apc11

Gene summary

Standard name
apc11
Systematic ID
SPAC343.03
Product
anaphase-promoting complex ubiquitin -protein ligase E3 subunit Apc11
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UT86
ORFeome ID
05/05E08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1643081..1644421 forward strand

Annotation

GO biological process

GO:0031145 - anaphase-promoting complex-dependent catabolic process

References:

GO:1901970 - positive regulation of mitotic sister chromatid separation

References:

GO cellular component

GO:0005680 - anaphase-promoting complex

References:

GO molecular function

GO:0097602 - cullin family protein binding

References:

GO:0061630 - ubiquitin protein ligase activity

References:

GO:0008270 - zinc ion binding

References:

Protein features

PBO:0111749 - ubiquitin-protein ligase E3

PBO:0111746 - zf-C3HC4 type (RING finger)

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF12861zf-ANAPC11RING-H2_APC11Pfam
cd16456RING-H2_APC11RING-H2_APC11CDD
PS50089ZF_RING_2Znf_RINGPROSITE profiles
G3DSA:3.30.40.10:FF:000460CATH-FunFam
G3DSA:3.30.40.10Znf_RING/FYVE/PHDCATH-Gene3D
SSF57850SUPERFAMILY
PTHR11210RING-box_E3_Ubiquitin_LigasePANTHER

Orthologs

References / Literature

GO_REF:0000002 - Comments
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16950791 - Role of Hcn1 and its phosphorylation in fission yeast anaphase-promoting complex/cyclosome function.
Yoon HJ et al. J Biol Chem 2006 Oct 27;281(43):32284-93
PMID:21389117 - Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.
Kimata Y et al. Mol Biol Cell 2011 May;22(9):1486-94
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:10651900 - Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin.
Yanagida M Genes Cells 2000 Jan;5(1):1-8
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:12477395 - Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes.
Yoon HJ et al. Curr Biol 2002 Dec 10;12(23):2048-54
PMID:15060174 - Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27.
Schwickart M et al. Mol Cell Biol 2004 Apr;24(8):3562-76
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:18556659 - The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).
Sczaniecka M et al. J Biol Chem 2008 Aug 22;283(34):23039-47
PMID:18082611 - Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.
Ohi MD et al. Mol Cell 2007 Dec 14;28(5):871-85
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22809626 - Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeast.
Wang Y et al. Mol Biol Cell 2012 Sep;23(17):3348-56
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623