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protein coding gene - vma1 (SPAC343.05) - V-type ATPase V1 domain, subunit A

Gene summary

Standard name
vma1
Systematic ID
SPAC343.05
Product
V-type ATPase V1 domain, subunit A
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P31406
ORFeome ID
27/27A06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 1647218..1649410 forward strand

Annotation

Disease association

MONDO:0027451 - autosomal recessive cutis laxa type 2D

References:

MONDO:0020632 - developmental and epileptic encephalopathy 93

References:

GO biological process

GO:0046034 - ATP metabolic process

References:

GO:1902600 - proton transmembrane transport

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GO cellular component

GO:0000329 - fungal-type vacuole membrane

References:

GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain

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GO molecular function

GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

References:

GO:0046961 - proton-transporting ATPase activity, rotational mechanism

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001621 - decreased cellular arginine level

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Genotypes:

FYPO:0001727 - decreased cellular glutamine level

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Genotypes:

FYPO:0001562 - decreased cellular histidine level

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Genotypes:

FYPO:0001617 - decreased cellular isoleucine level

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Genotypes:

FYPO:0001619 - decreased cellular lysine level

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Genotypes:

FYPO:0001616 - decreased cellular valine level

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Genotypes:

FYPO:0001612 - decreased vacuolar arginine level

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Genotypes:

FYPO:0001732 - decreased vacuolar glutamine level

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Genotypes:

FYPO:0001611 - decreased vacuolar histidine level

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Genotypes:

FYPO:0001610 - decreased vacuolar lysine level

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Genotypes:

FYPO:0003879 - delayed onset of age-related vacuolar changes

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Genotypes:

FYPO:0001731 - increased vacuolar glutamate level

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0001725 - normal cellular aspartate level

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Genotypes:

FYPO:0001726 - normal cellular cysteine level

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Genotypes:

FYPO:0001637 - normal cellular glycine level

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Genotypes:

FYPO:0001640 - normal cellular leucine level

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Genotypes:

FYPO:0001639 - normal cellular methionine level

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Genotypes:

FYPO:0001642 - normal cellular phenylalanine level

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Genotypes:

FYPO:0001643 - normal cellular tryptophan level

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Genotypes:

FYPO:0001641 - normal cellular tyrosine level

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Genotypes:

FYPO:0001627 - normal vacuolar alanine level

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Genotypes:

FYPO:0001624 - normal vacuolar asparagine level

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Genotypes:

FYPO:0001729 - normal vacuolar cysteine level

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Genotypes:

FYPO:0001626 - normal vacuolar glycine level

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Genotypes:

FYPO:0001630 - normal vacuolar isoleucine level

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Genotypes:

FYPO:0001631 - normal vacuolar leucine level

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Genotypes:

FYPO:0001629 - normal vacuolar methionine level

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Genotypes:

FYPO:0001633 - normal vacuolar phenylalanine level

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Genotypes:

FYPO:0001623 - normal vacuolar serine level

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Genotypes:

FYPO:0001622 - normal vacuolar threonine level

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Genotypes:

FYPO:0001634 - normal vacuolar tryptophan level

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Genotypes:

FYPO:0001628 - normal vacuolar valine level

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Genotypes:

FYPO:0003878 - sensitive to monensin

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Genotypes:

FYPO:0000757 - sensitive to nigericin

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02874ATP-synt_ab_NATPase_F1/V1/A1_a/bsu_NPFAM
PF00006ATP-synt_abATPase_F1/V1/A1_a/bsu_nucl-bdPFAM
PF22919ATP-synt_VA_CATP-synt_VA_CPFAM
PF16886ATP-synt_ab_XtnATP-synth_a_XtnPFAM
cd18111ATP-synt_V_A-type_alpha_CCDD
cd18119ATP-synt_V_A-type_alpha_NCDD
cd01134V_A-ATPase_ACDD
PS00152ATPASE_ALPHA_BETAATPase_a/bsu_ASPROSITE_PATTERNS
G3DSA:2.40.50.100:FF:000008FUNFAM
G3DSA:3.40.50.300:FF:000052FUNFAM
G3DSA:2.40.30.20:FF:000002FUNFAM
G3DSA:1.10.1140.10:FF:000002FUNFAM
SSF47917C-terminal domain of alpha and beta subunits of F1 ATP synthaseSUPERFAMILY
SSF50615N-terminal domain of alpha and beta subunits of F1 ATP synthaseATPase_F1/V1/A1_a/bsu_N_sfSUPERFAMILY
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:1.10.1140.10ATPase_F1/V1_b/a_CGENE3D
G3DSA:2.40.50.100GENE3D
G3DSA:2.40.30.20ATP_synth_asu-like_sfGENE3D
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
PTHR43607V-TYPE PROTON ATPASE CATALYTIC SUBUNIT AV-ATPase_asuPANTHER
MF_00309ATP_synth_A_archV-ATPase_asuHAMAP
NF003220PRK04192.1V-ATPase_asuNCBIFAM
TIGR01042V-ATPase_V1_AATPase_V1-cplx_asuNCBIFAM

Orthologs

References / Literature

PMID:18503766 - Identification of the fnx1+ and fnx2+ genes for vacuolar amino acid transporters in Schizosaccharomyces pombe.
Chardwiriyapreecha S et al. FEBS Lett 2008 Jun 25;582(15):2225-30
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:14735354 - Characterization of Schizosaccharomyces pombe mutants defective in vacuolar acidification and protein sorting.
Iwaki T et al. Mol Genet Genomics 2004 Mar;271(2):197-207
PMID:23521895 - Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension.
Stephan J et al. Aging Cell 2013 Aug;12(4):574-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.
Larochelle M et al. J Cell Sci 2019 May 31;132(11)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16291725 - btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.
Gachet Y et al. J Cell Sci 2005 Dec 01;118(Pt 23):5525-36
PMID:19734666 - A simple and specific procedure to permeabilize the plasma membrane of Schizosaccharomyces pombe.
Chardwiriyapreecha S et al. Biosci Biotechnol Biochem 2009 Sep;73(9):2090-5
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105