protein coding gene - gta2 (SPAC343.13) - mitochondrial glutamyl-tRNA amidotransferase beta subunit Gta2

Gene summary

Standard name: gta2
Systematic ID: SPAC343.13
Product: mitochondrial glutamyl-tRNA amidotransferase beta subunit Gta2
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: pet112
UniProt ID: Q9UT77
ORFeome ID: 35/35F01
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome I: 1670338..1672264 forward strand

Annotation

Disease association

MONDO:0030007 - combined oxidative phosphorylation deficiency 41

References:

PB_REF:0000006

GO biological process

GO:0032543 - mitochondrial translation

References:

GO_REF:0000033

GO cellular component

GO:0030956 - glutamyl-tRNA(Gln) amidotransferase complex

References:

GO_REF:0000033

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000111

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0050567 - glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

References:

GO_REF:0000033

Multi-locus phenotype

FYPO:0007359 - resistance to heavy water

References:

PMID:32142608

Genotypes:

efn2delta-913((-913)) gta2-T-intron(212-T-primary_transcript) mkh1-frameshift(227-CTATGTTCAAG)

Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

References:

PMID:33313903

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

gta2delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

gta2delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF02934	GatB_N	Asn/Gln-tRNA_Trfase_suB/E_cat	PFAM
PF02637	GatB_Yqey	Asn/Gln_amidotransferase	PFAM
PS01234	GATB	Gln-tRNA_amidoTrfase_suB_CS	PROSITE_PATTERNS
SM00845	gatb_yqey_2	Asn/Gln_amidotransferase	SMART
SSF89095	GatB/YqeY motif	Asn/Gln_tRNA_amidoTrase-B-like	SUPERFAMILY
SSF55931	Glutamine synthetase/guanido kinase	Gln_synth/guanido_kin_cat_dom	SUPERFAMILY
G3DSA:1.10.10.410		GatB_Yqey_C_2	GENE3D
PTHR11659	GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED	Asn/Gln-tRNA_amidoTrfase_suB/E	PANTHER
MF_00121	GatB	GatB	HAMAP
NF004012	PRK05477.1-2		NCBIFAM

Orthologs

GATB (HGNC:8849) Homo sapiens
gta2 (SJAG_01577) Schizosaccharomyces japonicus
PET112 (YBL080C) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:32142608 - Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water.: Kampmeyer C et al. ACS Synth Biol 2020 Apr 17;9(4):733-748
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399