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protein coding gene - kms1 (SPAC3A11.05c) - meiotic spindle pole body KASH domain protein Kms1

Gene summary

Standard name
kms1
Systematic ID
SPAC3A11.05c
Product
meiotic spindle pole body KASH domain protein Kms1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P87245
ORFeome ID
33/33F01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome I: 3462898..3465427 forward strand

Annotation

Disease association

MONDO:0014237 - autosomal recessive nonsyndromic hearing loss 76

References:

GO biological process

GO:1990683 - DNA double-strand break attachment to nuclear envelope

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GO:0045141 - meiotic telomere clustering

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GO cellular component

GO:0031021 - interphase microtubule organizing center

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GO:0034993 - meiotic nuclear membrane microtubule tethering complex

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GO:0044732 - mitotic spindle pole body

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GO:0031965 - nuclear membrane

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GO:1990612 - Sad1-Kms1 LINC complex

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GO molecular function

GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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Protein features

PBO:0111761 - EF hand

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PBO:0111886 - KASH domain protein

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002890 - abnormal horsetail nucleus morphology

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Genotypes:

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0000172 - abnormal meiotic telomere clustering

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0000913 - abnormal sporulation resulting in formation of ascus containing non-uniform spores

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0003263 - abnormal sporulation resulting in formation of ascus with more than four spores

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Genotypes:

FYPO:0004077 - abnormal sporulation resulting in formation of ascus with single large spore

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Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

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Genotypes:

FYPO:0000185 - decreased gene conversion during vegetative growth

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Genotypes:

FYPO:0000485 - decreased meiotic recombination

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0000513 - delayed onset of nuclear fusion during mating

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Genotypes:

FYPO:0003580 - increased number of Sad1 foci during response to DNA damage

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0001221 - normal nucleus:cytoplasm ratio

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009069 - sensitive to ciclopirox olamine

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
SSF47473EF-handEF-hand-dom_pairSUPERFAMILY
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22425159 - Transient structure associated with the spindle pole body directs meiotic microtubule reorganization in S. pombe.
Funaya C et al. Curr Biol 2012 Apr 10;22(7):562-74
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:24312672 - A quality control mechanism linking meiotic success to release of ascospores.
Guo H et al. PLoS One 2013;8(12):e82758
PMID:24943839 - A role for nuclear envelope-bridging complexes in homology-directed repair.
Swartz RK et al. Mol Biol Cell 2014 Aug 15;25(16):2461-71
PMID:24963130 - The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body.
Wälde S et al. J Cell Sci 2014 Aug 15;127(Pt 16):3625-40
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:22042620 - Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.
Tamm T et al. J Cell Biol 2011 Oct 31;195(3):467-84
PMID:16111942 - Hrs1p/Mcp6p on the meiotic SPB organizes astral microtubule arrays for oscillatory nuclear movement.
Tanaka K et al. Curr Biol 2005 Aug 23;15(16):1479-86
PMID:31015410 - Nuclear membrane protein Lem2 regulates nuclear size through membrane flow.
Kume K et al. Nat Commun 2019 Apr 23;10(1):1871
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:14655046 - Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast.
Miki F et al. Mol Genet Genomics 2004 Jan;270(6):449-61
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:9150257 - A novel fission yeast gene, kms1+, is required for the formation of meiotic prophase-specific nuclear architecture.
Shimanuki M et al. Mol Gen Genet 1997 Apr 16;254(3):238-49
PMID:20519959 - S. pombe genome deletion project: an update.
Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:10899136 - Telomere-led bouquet formation facilitates homologous chromosome pairing and restricts ectopic interaction in fission yeast meiosis.
Niwa O et al. EMBO J 2000 Jul 17;19(14):3831-40
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:11907273 - The 14-kDa dynein light chain-family protein Dlc1 is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast.
Miki F et al. Mol Biol Cell 2002 Mar;13(3):930-46
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623